Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis

Xu, Jia‐Ying; Meng, Qinghui; Chong, Yu; Jiao, Yang; Zhao, Lin; Rosen, Eliot M.; Fan, Saijun

doi:10.3892/or.2012.2024

Cited by 47 publications

(26 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier studies have documented that A. mexicana is likely to contain benzylisoquinoline alkaloids such as benzophenanthridines, sanguarine, rotoberberines and protopines, protomexicine, mexitin dehydrocorydalmine, jatrorrhizine, columbamine, dl-tetrahydrocoptisine and dihydrocoptisine [21,22,23,24,25,26]. In an independent study on rodents [22], A. mexicana extracts were found to be effective in curing ulcers induced with cystamine.…”

Section: Discussionmentioning

confidence: 99%

Antifungal and Anticancer Potential of Argemone mexicana L.

Kharat

2016

Medicines

View full text Add to dashboard Cite

Background: Medicinal plants are widely used to treat infectious diseases, metabolic disorders and cancer. Argemone mexicana L. (A. mexicana), commonly found on desolate land of Marathwada (Maharashtra, India) has been used to treat oral cavity infections. Methods: In this study, cold aqueous and methanolic extracts were prepared from A. mexicana stem and leaves. These extracts were tested for their antifungal and anticancer activities. The antifungal activity was tested using the agar well diffusion method, while the anticancer activity against immortalized cell lines was assessed by trypan blue assay. Results: It was observed that both cold aqueous and methanolic extracts of A. mexicana stem and leaves inhibited the growth of Mucor indicus, Aspergillus flavus, Aspergillus niger and Penicillum notatum. Antifungal activity of the extract was comparable to that of Amphoterecin-B. A. mexicana extracts had a cytotoxic effect on A549, SiHa and KB immortalized cell lines that were similar to that of berberine. Conclusion: The A. mexicana leaf and stems exhibit strong antifungal and anticancer potential.

show abstract

Section: Discussionmentioning

confidence: 99%

Antifungal and Anticancer Potential of Argemone mexicana L.

Kharat

2016

Medicines

View full text Add to dashboard Cite

show abstract

“…A down-regulation of pro-caspase 3, Bcl-2, clAP2, XIAP, and c-FLIPs [20,52] has been also observed in basal cell-like MDA-MB-231 human breast carcinoma cells treated with sanguinarine. The effect of sanguinarine treatment has been evaluated also on the expression levels of Bax and Bcl-2 proteins in immortalized human keratinocytes (HaCaT) [24,25] , human leukaemia JM1 and K562 cells [35] and in Hela and SiHa human cervical tumor cells [53] . These findings indicate that sanguinarine, depending on the dose employed, down-regulates the expression levels of Bcl-2 protein while increasing those of Bax protein, which is a key regulator of mitochondrial damage.…”

Section: Sanguinarine Induces Apoptosis In Tumor Cellsmentioning

confidence: 99%

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Gaziano

Moroni

Buè

et al. 2016

WJGO

View full text Add to dashboard Cite

Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis , and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice.

show abstract

“…In fact, sanguinarine induces apoptosis in a variety of cancer cells after cell cycle arrest (Adhami et al, 2004), caspase activation (Kim et al, 2008), depletion of cellular GSH (Debiton et al, 2003), modulation of Bcl-2 family members (Ahsan et al, 2007;Lee et al, 2012;Xu, et al, 2012), and upregulation of death receptor 5 [DR5; tumor necrosis factor-related apoptosis-inducing ligand R2 (TRAIL-R2)] (Hussain et al, 2007). Of note, it has been observed that sanguinarine sensitizes human gastric adenocarcinoma cells to TRAIL-mediated apoptosis (Choi et al, 2009) and that it induces apoptosis of human osteosarcoma cells through the extrinsic pathway (Park et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Improved Apoptotic Cell Death in Drug-Resistant Non–Small-Cell Lung Cancer Cells by Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Based Treatment

Gatti

Cossa

Tinelli

et al. 2013

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Since response to platinum-based therapy in non-small-cell lung cancer (NSCLC) is poor, the present study was designed to rationally identify novel drug combinations in cell models including the A549 cell line and the cisplatin-resistant subline A549/Pt, characterized by reduced sensitivity to cisplatin-induced apoptosis and by upregulation of efflux transporters of the ATP binding cassette (ABC) superfamily. Given the molecular features of these cells, we focused on compounds triggering apoptosis through different mechanisms, such as the mitochondria-targeting drug arsenic trioxide and the phenanthridine analog sanguinarine, which induce apoptosis through the extrinsic pathway. Sanguinarine, not recognized by ABC transporters, could overcome cisplatin resistance and, when used in combination with arsenic trioxide, was synergistic in A549 and A549/Pt cells. The arsenic trioxide/sanguinarine cotreatment upregulated genes implicated in apoptosis activation through the extrinsic pathway. Drug combination experiments indicated that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment improved arsenic trioxide/sanguinarine efficacy, a feature associated with a striking apoptosis induction, particularly in the cisplatin-resistant variant. Thus, a synergistic interaction between sanguinarine and arsenic trioxide could be obtained independent of relative cell sensitivity to arsenic trioxide, and an enhanced apoptosis induction could be achieved in combination with TRAIL through modulation of the extrinsic apoptotic pathway. Antitumor activity studies supported the interest of drug combinations including TRAIL in NSCLC, indicating that drug-resistant NSCLC cells can efficiently be killed by the combination of proapoptotic agents. Our results suggest that the molecular changes occurring in treated cells may be exploited to rationally hit surviving cells.

show abstract

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis

Cited by 47 publications

References 33 publications

Antifungal and Anticancer Potential of Argemone mexicana L.

Antifungal and Anticancer Potential of Argemone mexicana L.

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Improved Apoptotic Cell Death in Drug-Resistant Non–Small-Cell Lung Cancer Cells by Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Based Treatment

Contact Info

Product

Resources

About