NF-κB-dependent MicroRNA-125b Up-regulation Promotes Cell Survival by Targeting p38α upon Ultraviolet Radiation

Abstract

Background: UV radiation-induced miRNA expression modulates cellular stress response. Results: UV up-regulates miR-125b expression via ATM-dependent NF-B activation, which represses p38␣ expression. Conclusion: UV-induced miR-125b prevents prolonged p38␣ activation and thereby promotes cell survival. Significance: Up-regulation of miR-125b serves as a negative feedback mechanism to control p38␣ activity upon UV radiation, which may contribute to tumorigenesis of skin cancer.

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival

“…18,[20][21][22][23][24][25][26][27][28] Here we examine the expression of genes listed in Supplementary Table 3 for their response to transfection of control miRNA, miR-125B antagomiR, miR-29B mimic and miR-125B antagomiR in combination with miR-29B mimic. Figure 6a shows that MYBL2, AKT2, CDK4 and SP1 are inhibited by miR-29B mimic in THP-1 cells; we also observe that AKT2 and CDK4 are further inhibited by the addition of miR-125B antagomiR.…”

TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase

“…RNA Extraction, Reverse Transcription, and Quantitative Real-time PCR-Total RNA was extracted with TRIzol (Invitrogen) and retrotranscribed with a first-strand cDNA synthesis kit (Thermo Scientific). Real-time PCR analyses were performed in triplicate as described previously (33). The housekeeping gene GAPDH was used as an internal control.…”

A New Paradigm to Mitigate Osteosarcoma by Regulation of MicroRNAs and Suppression of the NF-κB Signaling Cascade

“…Although, these miRNAs can regulate not only NF-κB bio-molecular mechanism but also involve in various type of signaling pathways in neoplasia (Davis & Hata, 2009). On the other (Kim et al, 2012;Tan et al, 2012;Xia et al, 2014).…”

“…It is also essential to counter this PCD in cancer cells via dephosphorylation of BCl-2. Next, Tan et al (2012) showed, activation of NF-κB by UV is required for miR-125b induction in colon cancer and OS.…”

“…1) including OS (Xia et al, 2014). Dysfunctional NF-κB activity contributes to various human conditions, including autoimmune, inflammatory disorders and cancer by miR125a and miR-125b (Kim et al, 2012;Tan et al, 2012). It directly Inhibit tumor necrosis factor alpha-induced protein 3 (TNFAIP3) expression, down-regulate the p38α via UV that elevates NF-κB Activity in diffuse large B-cell lymphoma (DLBCL) and OS (Fig.…”