A New Paradigm to Mitigate Osteosarcoma by Regulation of MicroRNAs and Suppression of the NF-κB Signaling Cascade

Mongre, Raj Kumar; Sodhi, Simrinder Singh; Ghosh, Mrinmoy; Kim, Jeong Hyun; Kim, Nameun; Sharma, Neelesh; Jeong, Dong Kee

doi:10.12717/dr.2014.18.4.197

Cited by 15 publications

(9 citation statements)

References 79 publications

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“…Osteosarcoma is developed from the interstitial cell line, with strong infiltration and transfer capacity (8–10) PTEN is a tumor suppressor gene with phosphatase activity (11) and it has been reported that PTEN expression is reduced in a variety of human malignancies, such as breast cancer (12) and prostate cancer (13). PTEN has many important functions in the body, such as the inhibition of cell growth and differentiation (14) and promotion of cell apoptosis (15), making it one of the most noticeable tumor suppressor genes after the p53 gene.…”

Section: Discussionmentioning

confidence: 99%

Expression of NF-κB and PTEN in osteosarcoma and its clinical significance

Gong

Xiang

et al. 2017

Oncol Lett

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We investigated the role of nuclear factor-κB (NF-κB) and phosphatase and tensin homolog deleted in chromosome 10 (PTEN) in the pathogenesis of osteosarcoma and its relationship with prognosis. Immunohistochemical method was used to detect the expression of NF-κB and PTEN in osteosarcoma and adjacent tissues. RT-PCR was used to detect the expression of NF-κB and PTEN mRNA in osteosarcoma and adjacent tissues. Western blotting was used to detect the expression of NF-κB and PTEN in osteosarcoma and adjacent tissues and compare their differences. The expression of NF-κB and PTEN was detected in osteosarcoma and adjacent tissues. The positive rate of NF-κB was 75.3 and 32.9%, respectively; while the positive rate of PTEN was 67.1 and 90.4%, respectively. The positive expression of NF-κB and PTEN was statistically significant. There was a negative correlation between NF-κB and PTEN expression (r=−0.502, p<0.05). The positive and negative expression of NF-κB and PTEN was statistically significant for the five-year survival (p<0.05). At gene and protein level, osteosarcoma tissues had higher expression of NF-κB, and lower expression of PTEN, which was significantly different from the adjacent tissues. In osteosarcoma, NF-κB is highly expressed, but PTEN is expressed at low level, and the two are negatively correlated. This is of great significance for the early diagnosis of osteosarcoma and prognosis.

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Section: Discussionmentioning

confidence: 99%

Expression of NF-κB and PTEN in osteosarcoma and its clinical significance

Gong

Xiang

et al. 2017

Oncol Lett

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“… 134 , 135 The NF-κB signaling pathway is responsible for cell proliferation, apoptosis prevention, and transcriptional regulation of various genes in response to damaging agents and cytokines and plays an important role in the pathogenesis of osteosarcoma. 136 For example, miRNA-29a inhibits the proliferation of osteosarcoma cells by negatively regulating its target DNMT3B, which inhibits the SOCS1/NF-κB signaling pathway. 137 Meanwhile, downregulation of miRNA-155 expression also inhibited osteosarcoma cell proliferation and induced apoptosis through the NF-κB signaling pathway.…”

Section: The Role and Mechanism Of Mirnas In The Development Of Osteo...mentioning

confidence: 99%

Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma

Dong

Liao

et al. 2022

Technol Cancer Res Treat

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Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma. This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis.

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“…Today, anticancer therapies including radiotherapy, chemotherapy, combination, surgery, immunotherapy, and laser therapy are well reported; however, there is still dire need to discover a specific target in solid tumors [ 108 , 109 , 110 , 111 ]. Although, several new targets such as carbonic anhydrases, BCl2, Bax, TEAD, and HDACs are being explored to overcome drug resistance/drug failure in cancer management [ 112 , 113 , 114 ].…”

Section: Clinical Resistance To Small Molecule Inhibitor Targeting Rtks: Advances and Pitfalls Of Targeted Therapymentioning

confidence: 99%

Emerging Importance of Tyrosine Kinase Inhibitors against Cancer: Quo Vadis to Cure?

Mongre

Mishra

Shukla

et al. 2021

IJMS

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GLOBOCAN 2020 estimated more than 19.3 million new cases, and about 10 million patients were deceased from cancer in 2020. Clinical manifestations showed that several growth factor receptors consisting of transmembrane and cytoplasmic tyrosine kinase (TK) domains play a vital role in cancer progression. Receptor tyrosine kinases (RTKs) are crucial intermediaries of the several cellular pathways and carcinogenesis that directly affect the prognosis and survival of higher tumor grade patients. Tyrosine kinase inhibitors (TKIs) are efficacious drugs for targeted therapy of various cancers. Therefore, RTKs have become a promising therapeutic target to cure cancer. A recent report shows that TKIs are vital mediators of signal transduction and cancer cell proliferation, angiogenesis, and apoptosis. In this review, we discuss the structure and function of RTKs to explore their prime role in cancer therapy. Various TKIs have been developed to date that contribute a lot to treating several types of cancer. These TKI based anticancer drug molecules are also discussed in detail, incorporating their therapeutic efficacy, mechanism of action, and side effects. Additionally, this article focuses on TKIs which are running in the clinical trial and pre-clinical studies. Further, to gain insight into the pathophysiological mechanism of TKIs, we also reviewed the impact of RTK resistance on TKI clinical drugs along with their mechanistic acquired resistance in different cancer types.

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A New Paradigm to Mitigate Osteosarcoma by Regulation of MicroRNAs and Suppression of the NF-κB Signaling Cascade

Cited by 15 publications

References 79 publications

Expression of NF-κB and PTEN in osteosarcoma and its clinical significance

Expression of NF-κB and PTEN in osteosarcoma and its clinical significance

Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma

Emerging Importance of Tyrosine Kinase Inhibitors against Cancer: Quo Vadis to Cure?

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