Next step in 2nd generation glucose biosensors: Ferrocene-loaded electrospun nanofibers

Guven, Nese; Apetrei, Roxana-Mihaela; Çamurlu, Pınar

doi:10.1016/j.msec.2021.112270

Cited by 16 publications

(9 citation statements)

References 46 publications

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“…Figure 3c depicts the calibration curve for glucose with the bi‐enzyme biosensor. Linearity was found between 0.01–5.0 mM with a sensitivity of 31±5 μAmM −2 cm −2 and 3.7 μM LOD, similar to NFs‐based biosensors developed in our previous work [57,58] …”

Section: Resultssupporting

confidence: 82%

“…The morphological characterization of the PAN(À MWCNTs) NFs (SEM, TEM analyses) is detailed in several of our previous reports concerning glucose detection. [57,58] Shortly, the composite NFs displayed an average diameter of ~600 nm, and partial beading was observed at increased content of COOH-MWCNTs.…”

Section: Resultsmentioning

confidence: 99%

“…Linearity was found between 0.01-5.0 mM with a sensitivity of 31 � 5 μAmM À 2 cm À 2 and 3.7 μM LOD, similar to NFs-based biosensors developed in our previous work. [57,58] The analytical characteristics of the developed biosensors are competitive, if not superior, to many reported analogues in terms of sensitivity and LOD (Table 2). The comparison with relevant works reveals that ammonia electrooxidation in biosensors for urea detection is commonly achieved by catalysis with metal nanostructures.…”

Section: Analytical Figures Of Meritmentioning

confidence: 96%

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Discriminative detection of glucose and urea with a composite polymer nanofiber based matrix

Apetrei,

Guven,

Camurlu

2024

ChemistrySelect

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Detection and quantification of glucose and urea are fundamental in medical analysis, real‐time monitoring, and point of care analysis. However, such analyses generally require sophisticated instrumentation and specialized personnel. Furthermore, discriminative detection of multiple analytes is often necessary for treatment and diagnosis. To address this challenge, this study describes a proof‐of‐concept for discriminative sensitive amperometric detection of both analytes. This was achieved by the fabrication of a polymer‐MWCNTs composite nanofiber matrix upon which glucose oxidase (GOD) and urease were co‐immobilized to allow detection of the corresponding substrates (glucose and urea). The (PAN(−MWCNTs)/Urease‐GOD) biosensor showed good performance in: (i) glucose biosensing with sensitivity of 31±5 μAmM−2cm−2 within an extended linear range (0.1–5.0 mM) and a limit of detection of 3.7 μM, and (ii) urea detection at very low concentration (4–30 and 30–90 μM) with sensitivity up to 350±19 μAmM−2cm−2 and very low LOD (0.1 μM). The analogous mono‐enzyme platform for urea detection (PAN(−MWCNTs)/Urease) showed very similar performance as the bi‐enzyme sensor, suggesting little to no influence of co‐immobilization on Urease activity, thus confirming that the two catalytic processes are independent of each other. The biosensors exhibited high accuracy in the detection of both analytes (at normal and pathological levels) in human serum, thus proving that the biosensor described herein can have practical applications in healthcare and remote patient monitoring.

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Analytical Figures Of Meritmentioning

confidence: 96%

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Discriminative detection of glucose and urea with a composite polymer nanofiber based matrix

Apetrei,

Guven,

Camurlu

2024

ChemistrySelect

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“…However, the second-generation biosensors still face challenges from the distractors, mediator size, and diffusion molecules. The potential leaching of the electrode and nearby enzyme, and the instability of the response can both hinder the utility of second-generation glucose biosensors ( Guven et al, 2021 ). The incorporation of nanomaterials not only reduces the enzyme leaching rate and ensures the sensor reproducibility but also improves the electron transfer rate so that the biosensor has a higher sensitivity ( Liu et al, 2020a ).…”

Section: Background Knowledge For Glucose Sensorsmentioning

confidence: 99%

Electrospun nanofiber-based glucose sensors for glucose detection

Zhang

Liu

et al. 2022

Front. Chem.

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Diabetes is a chronic, systemic metabolic disease that leads to multiple complications, even death. Meanwhile, the number of people with diabetes worldwide is increasing year by year. Sensors play an important role in the development of biomedical devices. The development of efficient, stable, and inexpensive glucose sensors for the continuous monitoring of blood glucose levels has received widespread attention because they can provide reliable data for diabetes prevention and diagnosis. Electrospun nanofibers are new kinds of functional nanocomposites that show incredible capabilities for high-level biosensing. This article reviews glucose sensors based on electrospun nanofibers. The principles of the glucose sensor, the types of glucose measurement, and the glucose detection methods are briefly discussed. The principle of electrospinning and its applications and advantages in glucose sensors are then introduced. This article provides a comprehensive summary of the applications and advantages of polymers and nanomaterials in electrospun nanofiber-based glucose sensors. The relevant applications and comparisons of enzymatic and non-enzymatic nanofiber-based glucose sensors are discussed in detail. The main advantages and disadvantages of glucose sensors based on electrospun nanofibers are evaluated, and some solutions are proposed. Finally, potential commercial development and improved methods for glucose sensors based on electrospinning nanofibers are discussed.

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“…By incorporating these redox mediators into enzyme-based detection systems, the transduction of glucose sensing shifts from oxygen monitoring to monitoring the electrochemical signals of Fc. [23][24][25] Controlling the spatial distribution of GOD and the ferrocenyl residue is the key to improving the mediator's effects. Indeed, the distribution control of Fc and GOD at the molecular level through their covalent linking has been reported nearly thirty years before.…”

Section: Introductionmentioning

confidence: 99%

A flexible electrochemical glucose sensing platform based on an electrospun PVA mat covered with in situ grown silver nanoparticles and a mixed self-assembled monolayer of glucose oxidase and ferrocene

Wang¹,

Wang²,

Chai³

et al. 2023

Analyst

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Next step in 2nd generation glucose biosensors: Ferrocene-loaded electrospun nanofibers

Cited by 16 publications

References 46 publications

Discriminative detection of glucose and urea with a composite polymer nanofiber based matrix

Discriminative detection of glucose and urea with a composite polymer nanofiber based matrix

Electrospun nanofiber-based glucose sensors for glucose detection

A flexible electrochemical glucose sensing platform based on an electrospun PVA mat covered with in situ grown silver nanoparticles and a mixed self-assembled monolayer of glucose oxidase and ferrocene

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