Next-Generation Sequencing Identifies <i>BRCA1</i> and/or <i>BRCA2</i> Mutations in Women at High Hereditary Risk for Breast Cancer with Shorter Telomere Length

Eyüboğlu, İrem Peker; Yenmiş, Güven; Bingöl, Elif Naz; Yüksel, Şirin; Tokat, Fatma; Ozbek, Pemra; Amuran, Gökçe Gūllū; Yakıcıer, Cengiz; Akkiprik, Mustafa

doi:10.1089/omi.2019.0103

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…Notably, patients with human epidermal growth factor receptor 2 (HER2) + breast cancer had significantly longer telomeres than HER2 − patients ( 176 ). HER2 is a biological marker for disease prognosis and disease aggressiveness, and its association with telomere length may provide insight into disease progression and malignancy ( 177 ). These data indicate the complexity of the roles of telomeres in breast cancer pathogenesis.…”

Section: Reproductive Systemmentioning

confidence: 99%

“…Other examples are BRCA1 and BRCA2 gene mutations concerning telomere length and breast cancer susceptibility in women with a high hereditary risk of developing breast cancer. Thus, Eyüboǧlu et al ( 177 ) indicated that patients with BRCA1 and/or BRCA2 mutations had a 12% telomere attrition compared with women with no BRCA1 and/or BRCA2 mutations. Notably, BRCA2 mutations have been shown to be associated with the maintenance of telomere length ( 178 ).…”

Section: Reproductive Systemmentioning

confidence: 99%

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Role of telomere length in human carcinogenesis (Review)

et al. 2023

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Cancer is considered the most important clinical, social and economic issue regarding cause-specific disability-adjusted life years among all human pathologies. Exogenous, endogenous and individual factors, including genetic predisposition, participate in cancer triggering. Telomeres are specific DNA structures positioned at the end of chromosomes and consist of repetitive nucleotide sequences, which, together with shelterin proteins, facilitate the maintenance of chromosome stability, while protecting them from genomic erosion. Even though the connection between telomere status and carcinogenesis has been identified, the absence of a universal or even a cancer-specific trend renders consent even more complex. It is indicative that both short and long telomere lengths have been associated with a high risk of cancer incidence. When evaluating risk associations between cancer and telomere length, a disparity appears to emerge. Even though shorter telomeres have been adopted as a marker of poorer health status and an older biological age, longer telomeres due to increased cell growth potential are associated with the acquirement of cancer-initiating somatic mutations. Therefore, the present review aimed to comprehensively present the multifaceted pattern of telomere length and cancer incidence association.

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Section: Reproductive Systemmentioning

confidence: 99%

Section: Reproductive Systemmentioning

confidence: 99%