Association of circulating leukocyte telomere length with survival in patients with colorectal cancer

Pauleck, Svenja; Gigic, Biljana; Cawthon, Richard M.; Ose, Jennifer; Peoples, Anita R.; Warby, Christy A.; Sinnott, Jennifer A.; Lin, Tengda; Boehm, Juergen; Schrotz‐King, Petra; Li, Christopher I.; Shibata, David; Siegel, Erin M.; Figueiredo, Jane C.; Toriola, Adetunji T.; Schneider, Martin; Ulrich, Alexis; Hoffmeister, Albrecht; Ulrich, Cornelia M.; Hardikar, Sheetal

doi:10.1016/j.jgo.2021.12.008

Cited by 4 publications

(4 citation statements)

References 45 publications

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“…16 A previous report suggests that colorectal cancer patients with shorter telomeres due to aging may have shorter overall and disease-free survival. 17 Several studies have determined that recurrent gastric cancer patients have increased telomerase expression. 18 Telomerase activity is a prognostic factor for recurrence and survival in rectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Short telomere length in peripheral blood leukocytes predicts poor prognosis and indicates an immunosuppressive phenotype in gastric cancer patients 16 . A previous report suggests that colorectal cancer patients with shorter telomeres due to aging may have shorter overall and disease‐free survival 17 . Several studies have determined that recurrent gastric cancer patients have increased telomerase expression 18 .…”

Section: Discussionmentioning

confidence: 99%

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Telomere length in multiple cancer: insight into recurrence risk from a meta‐analysis

Gao

Zheng

et al. 2023

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Telomere length in multiple cancer: insight into recurrence risk from a meta‐analysis

Gao

Zheng

et al. 2023

J of Gastro and Hepatol

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“…Medical chart abstraction, as well as linkages to cancer registry and vital status records were used to obtain detailed information on clinical outcomes (e.g., survival, recurrence) in the ColoCare Study [ 28 , 34 , 35 ]. Survival was ascertained through reviews of patient medical records, state or national cancer and death registries at repeat intervals after surgery.…”

Section: Methodsmentioning

confidence: 99%

Associations of combined physical activity and body mass index groups with colorectal cancer survival outcomes

et al. 2023

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Background Physical activity and BMI have been individually associated with cancer survivorship but have not yet been studied in combinations in colorectal cancer patients. Here, we investigate individual and combined associations of physical activity and BMI groups with colorectal cancer survival outcomes. Methods Self-reported physical activity levels (MET hrs/wk) were assessed using an adapted version of the International Physical Activity Questionnaire (IPAQ) at baseline in 931 patients with stage I-III colorectal cancer and classified into ‘highly active’ and’not-highly active’(≥ / < 18 MET hrs/wk). BMI (kg/m2) was categorized into ‘normal weight’, ‘overweight’, and ‘obese’. Patients were further classified into combined physical activity and BMI groups. Cox-proportional hazard models with Firth correction were computed to assess associations [hazard ratio (HR), 95% profile HR likelihood confidence interval (95% CI) between individual and combined physical activity and BMI groups with overall and disease-free survival in colorectal cancer patients. Results ‘Not-highly active’ compared to ‘highly active’ and ‘overweight’/ ‘obese’ compared to ‘normal weight’ patients had a 40–50% increased risk of death or recurrence (HR: 1.41 (95% CI: 0.99–2.06), p = 0.03; HR: 1.49 (95% CI: 1.02–2.21) and HR: 1.51 (95% CI: 1.02–2.26), p = 0.04, respectively). ‘Not-highly active’ patients had worse disease-free survival outcomes, regardless of their BMI, compared to ‘highly active/normal weight’ patients. ‘Not-highly active/obese’ patients had a 3.66 times increased risk of death or recurrence compared to ‘highly active/normal weight’ patients (HR: 4.66 (95% CI: 1.75–9.10), p = 0.002). Lower activity thresholds yielded smaller effect sizes. Conclusion Physical activity and BMI were individually associated with disease-free survival among colorectal cancer patients. Physical activity seems to improve survival outcomes in patients regardless of their BMI.

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“…Telomeres in peripheral blood leukocytes are attracting more attention for their easy accessibility. Most recently, a relationship between telomere length in leukocytes of patients with stroke [ 122 ], osteosarcopenia [ 123 ], colorectal cancer [ 124 ], schizophrenia and related disorders [ 125 ], type 2 diabetes [ 126 ], and COVID-19 infection [ 117 ] has been shown.…”

Section: Cell-free Dna In Sars-cov-2 Infectionmentioning

confidence: 99%

The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections

Hovhannisyan,

Harutyunyan,

Aroutiounian

et al. 2023

IJMS

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Cell-free DNA (cfDNA) in human blood serum, urine, and other body fluids recently became a commonly used diagnostic marker associated with various pathologies. This is because cfDNA enables a much higher sensitivity than standard biochemical parameters. The presence of and/or increased level of cfDNA has been reported for various diseases, including viral infections, including COVID-19. Here, we review cfDNA in general, how it has been identified, where it can derive from, its molecular features, and mechanisms of release and clearance. General suitability of cfDNA for diagnostic questions, possible shortcomings and future directions are discussed, with a special focus on coronavirus infection.

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Association of circulating leukocyte telomere length with survival in patients with colorectal cancer

Cited by 4 publications

References 45 publications

Telomere length in multiple cancer: insight into recurrence risk from a meta‐analysis

Telomere length in multiple cancer: insight into recurrence risk from a meta‐analysis

Associations of combined physical activity and body mass index groups with colorectal cancer survival outcomes

The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections

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