Newly isolated marine bacterial exopolysaccharides enhance antitumor activity in HepG2 cells via affecting key apoptotic factors and activating toll like receptors

Medical application of exopolymers produced by marine bacteria

“…EPS produced by marine microbes have yielded pharmaceutical items, for example, novel anti-inflammatory agents, such as pseudopterosins, topsentins, scytonemin, and manoalide; anticancer agents (e.g., bryostatins, discodermolide, eleutherobin, and sarcodictyin); and anti-microbials (e.g., marinone). The use of probiotic microscopic organisms, i.e., bacteria, for example, lactobacilli and Bifidobacteria, is for the most part in the control of pathogenic microorganisms, through generation of antibacterial protein to be specific, bacteriocin (DeVugst and Vandamme 1994; Kathiresan and Thiruneelakandan 2008) and anticancer substances (Wollowski et al 2001;Meera et al 2011;Yahya et al 2019). The dietary enhancements of lactobacilli are purportedly diminishing the induction of colon cancer (Goldin and Gorbach 1992;Wu and Chen 2006;Selim et al 2018 a).…”

“…EPS can down direct P-glycoprotein and reverse MDR (De Vuyst and Degeest 1999;Ooi and Liu 2000;Laws et al 2001;Wei et al 2008 andKambourova et al 2009). Bioactive compounds have been the pillar of disease chemotherapy for as long as 30 years and are probably going to give a significant number of the lead structures, and these will be utilized as formats for the development of novel compounds with improved biological properties (John 2002;Poli et al 2010;Donato et al 2016;Elsakhawy et al, 2017;Yahya et al 2019).…”

“…A definitive explanation behind the suffering underlies in the comparability between tumor cells and normal cells. It is important to discover a treatment that could take out cancer cells while shielding ordinary cells from being slaughtered (Miller et al 1981;Matsuda et al 2003;Pang et al 2007;Pangestuti and Kim 2011;Yahya et al 2019). The capacity of bioactive EPS and polysaccharide bound proteins to balance such a large number of vital immune functions might be because of the basic structural diversity and variability of these molecules.…”

“…Moreover, EPS additionally have appeared with wide scope of different applications, for example, emulsification, thickness, absorption, film development, gel arrangement, and anticancer treatment (Lee et al 2001;Ohno et al 2001;Ke et al 2009;Thomas and Kim, 2013;Yahya et al 2019). EPS have great biological activity and assume jobs in the control of cell division and differentiation, immune regulation, and additionally have antitumor, antioxidant, and antiviral activities.…”

Exploring the Therapeutic Potentials of Exopolysaccharides Derived From Lactic Acid Bacteria and Bifidobacteria: Antioxidant, Antitumor, and Periodontal Regeneration

“…Numerous publications have demonstrated that EPSs possess a variety of biologically active properties, including antioxidant, immune-stimulating, and anticancer properties ( El-Adawi et al, 2012 ; El-Deeb et al, 2018 ; Angelin and Kavitha, 2020 ). In this regard, EPSs from the marine bacterium L. plantarum 70810 have shown an anti-proliferative effect on a hepatocellular cancer cell line (HepG2) ( Yahya et al, 2019 ). Rajoka et al (2018) investigated the bioactivity of the cell-free culture supernatant (CFCS) of Lactobacillus strains Lactobacillus casei SR1, L. casei SR2, and Lactobacillus paracasei SR4 obtained from human breast milk.…”