Cost-Benefit Analysis and Industrial Potential of Exopolysaccharides

Fukuda, Kenji; Kono, Hiroichi

doi:10.1007/978-3-030-75289-7_12

Cited by 1 publication

(1 citation statement)

References 239 publications

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“…There are still many environmental niches to investigate as potential sources of antibiotics (Karthik andKalyani, 2021, 2022). One such Actinomyces group Glutamicibacter genus is broadly utilized in the control, treatment, and prevention of diseases through the production of bioactive compounds, widely used as antibiotics (Phuong and Diep, 2020), anti-tumor, anti-tubercular (Khusro et al, 2020), anti-helminthic, anti-diabetic, anti-oxidant from an exo-polysaccharide (Xiong et al, 2020;Fukuda and Kono, 2021;Hidri et al, 2022), anti-angiogenic, growth hormones (Qin et al, 2018;Hidri et al, 2022), immuno-suppressors, neuritogenic (Tang et al, 2021), anti-inflammatory (Hui et al, 2021), anti-algal (Agamennone et al, 2018), anti-fungal with enzymatic source (Mihooliya et al, 2017;Asif et al, 2020), anti-proliferative (Baig et al, 2021), anti-parasitic, anti-malarial, anti-viral, anti-bacterial and many more biological applications (Nishioka and Katayama, 1978;Renner et al, 1999;Fernebro, 2011;Janardhan et al, 2014;Desouky et al, 2015;Abd-Elnaby et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative activity of antimicrobial peptides and bioactive compounds from the mangrove Glutamicibacter mysorens

et al. 2023

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The Glutamicibacter group of microbes is known for antibiotic and enzyme production. Antibiotics and enzymes produced by them are important in the control, protection, and treatment of chronic human diseases. In this study, the Glutamicibacter mysorens (G. mysorens) strain MW647910.1 was isolated from mangrove soil in the Mangalore region of India. After optimization of growth conditions for G. mysorens on starch casein agar media, the micromorphology of G. mysorens was found to be spirally coiled spore chain, each spore visualized as an elongated cylindrical hairy appearance with curved edges visualized through Field Emission Scanning Electron Microscopy (FESEM) analysis. The culture phenotype with filamentous mycelia, brown pigmentation, and ash–colored spore production was observed. The intracellular extract of G. mysorens characterized through GCMS analysis detected bioactive compounds reported for pharmacological applications. The majority of bioactive compounds identified in intracellular extract when compared to the NIST library revealed molecular weight ranging below 1kgmole−1. The Sephadex G-10 could result in 10.66 fold purification and eluted peak protein fraction showed significant anticancer activity on the prostate cancer cell line. Liquid Chromatography–Mass Spectrometry (LC–MS) analysis revealed Kinetin-9-ribose and Embinin with a molecular weight below 1 kDa. This study showed small molecular weight bioactive compounds produced from microbial origin possess dual roles, acting as antimicrobial peptides (AMPs) and anticancer peptides (ACPs). Hence, the bioactive compounds produced from microbial origin are a promising source of future therapeutics.

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