Newly identified vitamin K-producing bacteria isolated from the neonatal faecal flora

Cooke, Gordon B.; Behan, John; Costello, Mary Jean

doi:10.3402/mehd.v18i3-4.7681

Cited by 10 publications

(14 citation statements)

References 8 publications

(9 reference statements)

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“…Besides SCFA, gut microbiota-synthesized micronutrients such as vitamins exhibit beneficial value for both microbial and host metabolisms. Vitamin-K-producing gut bacteria namely Bacteroides fragilis, Eubacterium lentum, Enterobacter agglomerans, Serratia marcescens , and Enterococcus faecium ( Fernandez and Collins, 1987 ; Cooke et al, 2006 ) anaerobically synthesize vitamin K2 (menaquinone) which is essential in decreasing vascular calcification, elevating HDL and lowering cholesterol levels, contributing to lower risk of cardiovascular disorders such as atherosclerosis and coronary heart disease ( Kawashima et al, 1997 ; Geleijnse et al, 2004 ). Gut microbiota also serves as an important source of vitamins B for the host ( Salminen et al, 1998 ; Degnan et al, 2014 ).…”

Section: The Gut Microbiome and Its Multifarious Functionsmentioning

confidence: 99%

The Human Gut Microbiome – A Potential Controller of Wellness and Disease

2018

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Interest toward the human microbiome, particularly gut microbiome has flourished in recent decades owing to the rapidly advancing sequence-based screening and humanized gnotobiotic model in interrogating the dynamic operations of commensal microbiota. Although this field is still at a very preliminary stage, whereby the functional properties of the complex gut microbiome remain less understood, several promising findings have been documented and exhibit great potential toward revolutionizing disease etiology and medical treatments. In this review, the interactions between gut microbiota and the host have been focused on, to provide an overview of the role of gut microbiota and their unique metabolites in conferring host protection against invading pathogen, regulation of diverse host physiological functions including metabolism, development and homeostasis of immunity and the nervous system. We elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of host machineries, thereby contributing to pathogenesis and/or progression toward a broad spectrum of diseases. Some of the most notable diseases namely Clostridium difficile infection (infectious disease), inflammatory bowel disease (intestinal immune-mediated disease), celiac disease (multisystemic autoimmune disorder), obesity (metabolic disease), colorectal cancer, and autism spectrum disorder (neuropsychiatric disorder) have been discussed and delineated along with recent findings. Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment. Toward the end of this review, several research gaps and limitations have been described along with suggested future studies to overcome the current research lacunae. Despite the ongoing debate on whether gut microbiome plays a role in the above-mentioned diseases, we have in this review, gathered evidence showing a potentially far more complex link beyond the unidirectional cause-and-effect relationship between them.

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Section: The Gut Microbiome and Its Multifarious Functionsmentioning

confidence: 99%

The Human Gut Microbiome – A Potential Controller of Wellness and Disease

2018

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“…In white shrimp Litopenaeus vannamei and Fenneropenaeus indicus vast strains of Bacillus have been tested as probiotics in order to improve dry matter digestibility, phosphorus, and crude protein. Consequences of Bacillus administration with a dose of 50 g kg −1 feed revealed higher growth sizes [96] . Other research has suggested the importance of managing the probiotic in all ontogenetic stages of the shrimp to generate a constant effect on the production of digestive enzymes [97] .…”

Section: Digestion Enhancementmentioning

confidence: 96%

“…Vitamin products are among the valuable output of the probiotics. In vitro studies and humans trials have archived the capacity of some selected probiotic strains to compose Vitamin k [96] , folic Acid [97] and B12 [122] . LeBlanc et al [123] stated that certain lactic acid bacteria (LAB) have the privilege of synthesizing water-soluble vitamins such as the B-group (e.g.…”

Section: Vitamin Productionmentioning

confidence: 99%

Evolution of probiotics in aquatic world: Potential effects, the current status in Egypt and recent prospectives

Ibrahem

2015

Journal of Advanced Research

142

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“…Other gut bacteria have been previously identified as menaquinones producers of various chain lengths, such as Bacteroides ovatus, Enterococcus faecalis, Escherichia coli, Prevotellabuccae,Staphylococcus epidermidis, and Staphylococcus haemolyticus. Some strains isolated from feces of exclusively formula-fed infants were reported as vitamin K producers, e.g., Bacteroides spp., Citrobacter freundii, Enterobacter agglomerans, Enterococcus faecium, Serratia marcescens, Staphylococcus capitis, and Staphylococcus warneri, these bacterial strains are predominantly facultative anaerobes associated with the young neonatal gut where the environment is more anaerobic [82].…”

Section: Effect Of Vitamin K-producing Bacteriamentioning

confidence: 99%

Gut Microbiota and the Quality of Oral Anticoagulation in Vitamin K Antagonists Users: A Review of Potential Implications

Camelo-Castillo

Rivera‐Caravaca

Orenes‐Piñero

et al. 2021

JCM

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The efficacy and safety of vitamin K antagonists (VKAs) as oral anticoagulants (OACs) depend on the quality of anticoagulation control, as reflected by the mean time in therapeutic range (TTR). Several factors may be involved in poor TTR such as comorbidities, high inter-individual variability, interacting drugs, and non-adherence. Recent studies suggest that gut microbiota (GM) plays an important role in the pathogenesis of cardiovascular diseases, but the effect of the GM on anticoagulation control with VKAs is unknown. In the present review article, we propose different mechanisms by which the GM could have an impact on the quality of anticoagulation control in patients taking VKA therapy. We suggest that the potential effects of GM may be mediated first, by an indirect effect of metabolites produced by GM in the availability of VKAs drugs; second, by an effect of vitamin K-producing bacteria; and finally, by the structural modification of the molecules of VKAs. Future research will help confirm these hypotheses and may suggest profiles of bacterial signatures or microbial metabolites, to be used as biomarkers to predict the quality of anticoagulation. This could lead to the design of intervention strategies modulating gut microbiota, for example, by using probiotics.

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Newly identified vitamin K-producing bacteria isolated from the neonatal faecal flora

Cited by 10 publications

References 8 publications

The Human Gut Microbiome – A Potential Controller of Wellness and Disease

The Human Gut Microbiome – A Potential Controller of Wellness and Disease

Evolution of probiotics in aquatic world: Potential effects, the current status in Egypt and recent prospectives

Gut Microbiota and the Quality of Oral Anticoagulation in Vitamin K Antagonists Users: A Review of Potential Implications

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