Newly developed surface modification punches treated with alloying techniques reduce sticking during the manufacture of ibuprofen tablets

Mechanism and Kinetics of Punch Sticking of Pharmaceuticals

“…One recent strategy along this line is the alteration of punch-surface material that could result in reduced F1 as well as preclude the effect of lubrication on tablet tensile strength. 12,33,34 Another important aspect is that anisotropy of organic crystals can lead to different F1 when crystal shape is changed due to exposure of different functional groups to punch surface. 35 Therefore, a change in API morphology could lead to a change in punch sticking performance as observed for MA.…”

“…For example, the same IBN-based formulations exhibited different extent of sticking when the punch construction material was changed, suggesting a key role played by the punch-tablet adhesion in sticking propagation. 12 Along this line of thinking, particlepunch adhesion was determined by measuring the force required to detach particles deposited on to substrates of steel, brass, or polytetrafluoroethylene inside a centrifuge tube 13 or by atomic force microscopy (AFM). 5 Powder-punch adhesion, estimated using scrapper force, was also used to evaluate influence of powder properties, temperature, and humidity conditions on punch sticking.…”

Modeling of Adhesion in Tablet Compression at the Molecular Level Using Thermal Analysis and Molecular Simulations

“…Therefore, sticking is not only drug molecule-specific but is also dependent on drugs’ solid-state properties, including polymorphic form and crystal morphology. − The complexity of tablet adhesion makes the tableting process highly unpredictable and more challenging to identify the root cause of tablet sticking. Different approaches have been adopted to understand or ameliorate the primary mechanism of sticking and picking, including crystal engineering, − atomic force microscopy (AFM), ,, addition of lubricant or coprocessed excipients, , nanocoating to powder, − and different surface modifications to punches using available coating options. − However, all of these approaches are focused on the bulk or particulate level. Sticking and picking issues can be addressed by optimizing formulation components or alteration in the compression tooling.…”

Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

“…These can severely decrease the tablet quality, yield, and productivity. [4][5][6] Till now, certain strategies have been used to resolve the problem of punch sticking of ETs that occurs during compaction. Traditionally, several water-soluble lubricants (like macrogol 6000) are oen added in ETs, which can disperse on the surfaces of steel and/or effervescent granules to decrease their contact during tableting and therefore reduce the risk of sticking.…”