Newly developed gas-assisted sonodynamic therapy in cancer treatment

Pan, Meng; Hu, Danrong; Yuan, Liping; Yu, Yan; Li, Yicong; Zhang, Qian

doi:10.1016/j.apsb.2022.12.021

Cited by 9 publications

(4 citation statements)

References 223 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The degradability of MOFs under physiological conditions can be a primary determinant of their toxicity and efficacy in vivo. , To explore this issue, TEM images of LPCN-224 nanoparticles dispersed in 0.9% saline, DMEM supplemented with 10% FBS, and PBS (pH 7.4) for different periods were captured, and the relevant results are shown in Figure h. After being dispersed in 0.9% saline and DMEM (+10% FBS) for 24 h, the nanoparticles basically showed a spherical morphology.…”

Section: Resultsmentioning

confidence: 99%

Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Colocalization of Nanoparticle-Cargo in the Skin and Enhancement of Sonodynamic Efficacy

Sun,

Wang,

Bao

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Sonodynamic therapy (SDT) is a novel therapeutic modality that is effective for the noninvasive treatment of dermatological diseases. As a ubiquitous large class of sonosensitizers, however, porphyrins suffer from poor skin permeability and the inefficient generation of reactive oxygen species. Herein, different-sized porphyrinic metal−organic frameworks (MOFs), 125, and 200 nm), were developed via the coordination of tetra-kis(4-carboxyphenyl) porphyrin (TCPP) and the metal zirconium to enhance the local delivery of porphyrins, and fluorescent sonosensitizers (methylene blue or rhodamine 6G) were further incorporated to improve the sonodynamic effect, as well as to visualize the delivery of PCN-224 and its cargo. The skin penetration of PCN-224 was found to be increased with the reduction of particle size, and all three-sized samples could overcome the barrier of stratum corneum, even achieving the dermis of the porcine skin. Both intercellular and follicular pathways were noticed for three-sized PCN-224, while the follicular one played a more significant role in the penetration of the smallest PCN-224. The intact nanoparticles were found in the skin. At the initial stage, the nanoparticle and its cargo penetrated the skin as an intact entity, while the encapsulated rhodamine 6G was slowly released to the microenvironment of the skin from the nanoparticle with the prolongation of application. The combination of PCN-224 and methylene blue could increase the acoustically triggered generation of 1 O 2 , distinctly boosting the lethal effect against the cancerous cell. Collectively, the study revealed the feasibility of PCN-224 for topical use, suggested an innovative method to enhance the sonodynamic effect, and proposed a possible mechanism for skin drug delivery of MOFs.

show abstract

Section: Resultsmentioning

confidence: 99%

Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Colocalization of Nanoparticle-Cargo in the Skin and Enhancement of Sonodynamic Efficacy

Sun,

Wang,

Bao

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…As a safe and effective treatment modality, gas therapy has attracted extensive concern as a way to enhance the efficacy of SDT [ 168 ]. These gases with special therapeutic effects include H 2 S, CO 2 , O 2 , NO, CO, etc ., each of which has a different antitumor mechanism.…”

Section: Isdt For Cancermentioning

confidence: 99%

Nanomaterials augmented bioeffects of ultrasound in cancer immunotherapy

Xie,

Zhang,

Wang

et al. 2024

Materials Today Bio

View full text Add to dashboard Cite

“…In the high-speed operating conditions of the RV reducer, due to the friction between the parts, the working temperature will rise rapidly. Greases operating in high-temperature environments are prone to physical and chemical changes or changes in soap fibre structure, which in turn lead to changes in the rheological and tribological properties of the grease [7][8][9][10]. Therefore, it is important to study the performance of the grease itself in different environments.…”

Section: Introductionmentioning

confidence: 99%

Rheological characteristics and behaviour prediction of lubricating grease for RV reducer across a wide temperature range

Jiang,

Zhou,

et al. 2024

The Journal of Engineering

View full text Add to dashboard Cite

Grease in the normal operation of the rotate vector (RV) reducer has a role that cannot be ignored, for the variable working conditions of the RV reducer, the performance of the lubricant changes directly affect its reliable operation. Therefore, the study of the rheological properties of the grease has become the focus of the study of RV reducer performance. Here, SK‐1A grease is taken as the research object, and its rheological characteristics under wide temperature range working conditions (−20–40°C) are investigated through rheological experiments to analyze the potential influence of the performance of RV reducer. However, the ordinary way of research is too complicated to better research the rheological properties of grease for a variety of working conditions. The Elman neural network (ENN) model was used to predict the rheological properties, and the results were compared with those of back propagation (BP) and radial basis function (RBF) neural networks. The results demonstrate that the ENN model demonstrates high prediction accuracy for grease rheological property prediction by comparing three types of predictions. This method can provide a theoretical reference for the accurate prediction of the rheological properties of lubricating grease affected by complex multifactors.

show abstract

Newly developed gas-assisted sonodynamic therapy in cancer treatment

Cited by 9 publications

References 223 publications

Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Colocalization of Nanoparticle-Cargo in the Skin and Enhancement of Sonodynamic Efficacy

Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Colocalization of Nanoparticle-Cargo in the Skin and Enhancement of Sonodynamic Efficacy

Nanomaterials augmented bioeffects of ultrasound in cancer immunotherapy

Rheological characteristics and behaviour prediction of lubricating grease for RV reducer across a wide temperature range

Contact Info

Product

Resources

About