We report 1,656 new star clusters found in the Galactic disk (|b|<20 degrees) beyond 1.2 kpc, using Gaia EDR3 data. Based on an unsupervised machine learning algorithm, DBSCAN, and followed our previous studies, we utilized a unique method to do the data preparation and obtained the clustering coefficients, which proved to be an effective way to search blindly for star clusters. We tabulated the physical parameters and member stars of the new clusters, and presented some interesting examples, including a globular cluster candidate. The cluster parameters and member stars are available at CDS via anonymous ftp to https://cdsarc.cds.unistra.fr/ftp/vizier.submit//he22c. We examined the new discoveries and discussed their statistical properties. The proper motion dispersions and radii of star clusters are the same as the previously reported. The new clusters beyond 1.2 kpc are older than those in the solar neighborhood, and the new objects found in the third Galactic quadrant present the lowest line-of-sight extinctions. Combined with our previous results, the total population of new clusters and candidates detected through our method is 2,541, corresponding to 55% of all newly published clusters in the Gaia era. The number of cataloged Gaia star clusters was also increased to nearly six thousand. In the near future, it is necessary to make an unified confirmation and member star determination for all reported clusters.