Newer N-substituted anthranilic acid derivatives as potent anti-inflammatory agents

Sharma, Shalabh; Srivastava, Vinay Kumar; Kumar, Ashok

doi:10.1016/s0223-5234(02)01340-5

Cited by 80 publications

(34 citation statements)

References 8 publications

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“…Schiff bases, the condensation product of primary amine and active carbonyl groups, represents valuable intermediates in organic synthesis 3 . Schiff bases acquired broad spectrum of biological activities like antibacterial 4 , antifungal 5 , anti-inflammatory 6 , antiproliferative 7 , anti-tubercular 8 and anti-convulsant 9 . Biocidal activities of Schiff bases have been well established and attributed to the toxophoric C=N linkage in them 10 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Pharmacological Activity of Novel 1-(3/-Substituted Phenyl-5/-Imino-Aryl Pyrimidine)-3-(Substituted Phenyl)-5-(Substituted Phenyl)-2-Pyrazoline Analogues

Hatwar¹,

Narule²,

Dixit³

2017

Int. Res. J. Pharm.

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A series of novel 1-(3 / -substituted phenyl-5 / -imino-aryl pyrimidine)-3-(substituted phenyl)-5-(substituted phenyl)-2-pyrazoline analogues 2(a-i) have been synthesized by refluxing amino pyrimidine embedded 1,3,5-trisubstituted-2-pyrazolines 1 with different aromatic aldehydes and characterized by elemental analysis, FTIR, NMR( 1 H, 13 C) and Mass spectrometry. All compounds have been screened for their antibacterial activities against Bacillus substilis, Streptococcus aureus: gram positive strain, Pseudomonas aeruginosa, Escherichia coli: gram negative strain and antifungal activities against Aspergillus niger comparable to reference standard ciprofloxacin and fluconazole by agar-well diffusion method. 2a, 2d, 2f, 2g, 2i showed good antibacterial activity compared to the standard drug ciprofloxacin. 2b, 2c, 2d, 2e, 2f displayed moderate antifungal activity compared to the standard drug fluconazole. All compounds exhibited high activity for Streptococcus aureus and moderate to high activity against Pseudomonas aeruginosa and Bacillus substilis.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Pharmacological Activity of Novel 1-(3/-Substituted Phenyl-5/-Imino-Aryl Pyrimidine)-3-(Substituted Phenyl)-5-(Substituted Phenyl)-2-Pyrazoline Analogues

Hatwar¹,

Narule²,

Dixit³

2017

Int. Res. J. Pharm.

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“…Since the first pyrazolin-5-one was prepared by Knorr [4] in 1883, many papers have reported on the anti-inflammatory, analgesic and antipyretic evaluation of several pyrazoles, pyrazolin-3-ones and pyrazolidine-3,5-diones [5][6][7][8][9]. Many of these derivatives such as phenylbutazone, febrazone, feclobuzone, mefobutazone, suxibuzone and ramifenazone have found their clinical application as nonsteroidal anti-inflammatory drugs (NSAIDs) [10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of pyrazoles containing benzofuran and trifluoromethyl moieties as possible anti-inflammatory and analgesic agents

Farag

Shehry

Abbas

et al. 2015

Zeitschrift Für Naturforschung B

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Searching for new anti-inflammatory and analgesic agents, we have prepared a series of novel pyrazoles containing benzofuran and trifluoromethyl moieties. The pyrazole derivatives have been synthesized via two routes starting from 5-(3-(trifluoromethyl)phenyl azo) salicylaldehyde. The first route involved the synthesis of 2-acetylbenzofuran and then treatment with aldehydes to afford the corresponding chalcones. The cyclization of the latter chalcones with hydrazine hydrate led to the formation of new pyrazoline derivatives. The second route involved the synthesis of benzofuran-2-carbohydrazide and then treatment with formylpyrazoles, chalcones and ketene dithioacetal derivatives to afford the corresponding pyrazole derivatives. Some of the synthesized compounds exhibited anti-inflammatory and analgesic activities.

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“…The well-known use of 1,3,4-oxadiazole derivatives as a scaffold in modern medicinal chemistry [6], as verified by these specimens, establishes this moiety as a member of the prosperous structures course. Nevertheless, apart from their common use, procedures based on dehydrative cyclisation (Scheme 1) of semicarbazides are often used and remarkably involve tough reagents such as concentrated sulfuric acid [7,8] or phosphoryl chloride (POCl 3 ) [9]. On the other hand, reagents that primarily initiate one carbonyl group for backing cyclization have been used.…”

Section: Introductionmentioning

confidence: 99%

A new and efficient method for the synthesis of 2-N-(aryl)-1,3,4-oxadiazole-2,5-diamine derivatives

et al. 2015

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We report a series of cyclic analogues of 2,5-diamino-1,3,4-oxadiazoles which were prepared in a simple and general protocol. This method involves easy cyclisation of N-(aryl)-1,2-hydrazinedicarboxamides and mediated by tosylchloride/ pyridine in ethanol (solvent) under a reflux condition (79-80°C), over a time period of 20 h. We prepared different examples in a higher range of yields (80-98 %) by using this protocol.

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Newer N-substituted anthranilic acid derivatives as potent anti-inflammatory agents

Cited by 80 publications

References 8 publications

Synthesis, Characterization and Pharmacological Activity of Novel 1-(3/-Substituted Phenyl-5/-Imino-Aryl Pyrimidine)-3-(Substituted Phenyl)-5-(Substituted Phenyl)-2-Pyrazoline Analogues

Synthesis, Characterization and Pharmacological Activity of Novel 1-(3/-Substituted Phenyl-5/-Imino-Aryl Pyrimidine)-3-(Substituted Phenyl)-5-(Substituted Phenyl)-2-Pyrazoline Analogues

Synthesis of pyrazoles containing benzofuran and trifluoromethyl moieties as possible anti-inflammatory and analgesic agents

A new and efficient method for the synthesis of 2-N-(aryl)-1,3,4-oxadiazole-2,5-diamine derivatives

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