A series of novel 1-(3 / -substituted phenyl-5 / -imino-aryl pyrimidine)-3-(substituted phenyl)-5-(substituted phenyl)-2-pyrazoline analogues 2(a-i) have been synthesized by refluxing amino pyrimidine embedded 1,3,5-trisubstituted-2-pyrazolines 1 with different aromatic aldehydes and characterized by elemental analysis, FTIR, NMR( 1 H, 13 C) and Mass spectrometry. All compounds have been screened for their antibacterial activities against Bacillus substilis, Streptococcus aureus: gram positive strain, Pseudomonas aeruginosa, Escherichia coli: gram negative strain and antifungal activities against Aspergillus niger comparable to reference standard ciprofloxacin and fluconazole by agar-well diffusion method. 2a, 2d, 2f, 2g, 2i showed good antibacterial activity compared to the standard drug ciprofloxacin. 2b, 2c, 2d, 2e, 2f displayed moderate antifungal activity compared to the standard drug fluconazole. All compounds exhibited high activity for Streptococcus aureus and moderate to high activity against Pseudomonas aeruginosa and Bacillus substilis.
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