Newer drugs for heart failure: hype or hope?

Ghali, Jalal K.

doi:10.1080/13543784.2017.1259410

Cited by 1 publication

(2 citation statements)

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“…According to a report, the readmission rate from three months to one year is 30-50%, in patients with heart failure [3]. Among all other factors, an increase in heart rate is a significant predictor of cardiovascular mortality and hospitalizations in patients with cardiac failure [4]. A resting heart rate of more than 60 directly increases the risk.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Efficacy of Ivabradine With Traditional Therapy in Patients With Left Ventricular Dysfunction

Ali¹,

Ahmad²,

Khan³

et al. 2021

Cureus

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Background: Heart failure patients usually present with disease exacerbation that overburdens the hospitals and also increases the risk of mortality with increased heart rate being the main issue. Consideration is being given to drugs for sole heart rate control in addition to conventional therapy. Objective: To compare the outcomes of ivabradine to traditional treatment in patients with left ventricular systolic dysfunction. Methodology: This randomized controlled trial was conducted in the Department of Cardiology, Khyber Teaching Hospital, Peshawar from November 1, 2020, to May 31, 2021. Patients aged 30-65 years of age and of either gender with heart failure were enrolled in the study. Patients were screened for New York Heart Association (NYHA) class and were enrolled into one of the two groups. In group 1, patients were started on traditional treatment, while group 2 patients were given ivabradine as an add-on therapy. Follow-up was made at the end of the second month for evaluation of the outcomes. Results: Each group had 119 patients, with a mean age of 58.05±4.98 years. Group 1, consisted of 61.3% of the patients in NYHA 3, while 38.65% were in NYHA 4. In group 2, NYHA 3 and NYHA 4 patients were 59.6% and 40.3%, respectively. Upon follow-up, there were greater improvements in group 2 as compared to group 1 based on NYHA classifications, with NYHA 2 [47.05% (group 2) vs. 13.44% (group 1)], NYHA 3 [42.85% (group 2) vs. 61.34% (group 1)] and NYHA 4 [10.08% (group 2) vs. 25.21% (group 1)], p < 0.05. Conclusions: Obtaining a more optimal heart rate with ivabradine in patients with congestive heart failure is reflected in an improvement in NYHA classification.

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Section: Introductionmentioning

confidence: 99%

“…Among all other factors, an increase in heart rate is a significant predictor of cardiovascular mortality and hospitalizations in patients with cardiac failure [ 4 ]. A resting heart rate of more than 60 directly increases the risk.…”

Section: Introductionmentioning

confidence: 99%