New Xenia Diterpenoids from the Indonesian Soft Coral<i>Xenia</i>sp.

Anta, Cristina; González, Noemí; Santafé, Gílmar; Rodrı́guez, Jaime; Jiménez, Carlos

doi:10.1021/np010488x

Cited by 41 publications

(45 citation statements)

References 11 publications

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“…A Druinella species, also from Fiji, was found to contain purealidin S 342 and purpuramine J 343, which were both moderately cytotoxic. 422 Seven mildly cytotoxic xenicane-skeletoned diterpenes 580-586 were isolated from Xenia umbellata collected off Taiwan. 333 Bastadin 21 346 was isolated from Ianthella quadrangulata from Queensland, Australia.…”

Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2004

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This review covers the literature published in 2002 for marine natural products, with 579 citations (413 for the period January to December 2002) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms. The emphasis is on new compounds (677 for 2002), together with their relevant biological activities, source organisms and country of origin. Syntheses that lead to the revision of structures or stereochemistries have been included (114), including any first total syntheses of a marine natural product.

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Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2004

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“…Soft corals belonging to the genus Xenia are a rich source of diterpenoids, 12,25 A major limitation regarding the exploration of natural products from marine invertebrates, especially diterpenes, has been the difficulty in obtaining these compounds in sufficient quantities. 1,27 First, attempting to reisolate reasonable amounts of the same compound from the organism is difficult given the changing natural growth environment of these organisms.…”

Section: Resultsmentioning

confidence: 99%

Induction of Apoptosis by Diterpenes from the Soft Coral Xenia elongata

et al. 2007

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Four new diterpenes ( 1- 4) were isolated from the soft coral Xenia elongata using a novel cell-based screen for apoptosis-inducing, potential anticancer compounds. The molecular structures of the diterpenes were determined using a combination of NMR and mass spectrometry. The bioactivities were confirmed using a specific apoptosis induction assay based on genetically engineered mammalian lines with differential, defined capacities for apoptosis. The diterpenes induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by marine diterpenes in xenicane skeletons.

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“…Xenia sp. berpotensi sitotoksik (Anta, González, Santafé, Rodríguez & Jiménez, 2002dan Fattorusso et al, 2008 dan antibakteri (Kantor, Wewengkang & Wullur, 2015). Lobophytum sp.…”

Section: Pendahuluanmentioning

confidence: 99%

Aktivitas Antioksidan Ekstrak Karang Lunak Asal Teluk Palu, Sulawesi Tengah, Indonesia

Dewanto

Finarti

Hermawan

et al. 2019

JPBKP

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ABSTRAKBioaktif antioksidan merupakan substansi yang penting bagi kesehatan manusia. Karang lunak telah diketahui memproduksi bioaktif dengan keragaman struktur dan aktivitas biologi, termasuk memproduksi bioaktif antioksidan. Tujuan penelitian ini adalah untuk mendapatkan bioprospeksi karang lunak dari perairan Teluk Palu sebagai penghasil antioksidan. Penelitian meliputi pengambilan sampel, identifikasi, ekstraksi (maserasi) karang lunak, skrining konstituen kimia, pengujian aktivitas antioksidan (penangkapan radikal DPPH), dan penentuan IC 50 . Pengambilan sampel dilakukan di Teluk Palu, pesisir desa Kabonga Besar, Kabupaten Donggala, Sulawesi Tengah. Berdasarkan bentuk koloni monomorfik, tujuh sampel karang lunak yang digunakan pada penelitian ini termasuk dalam genus Sinularia, Dampia dan Sarcophyton. Analisis konstituen kimia mengindikasikan adanya senyawa saponin, fenolik, triterpenoid, dan alkaloid. Hasil pengujian aktivitas antioksidan dengan metode DPPH, menunjukkan ekstrak kasar karang lunak menunjukkan persentase inhibisi radikal DPPH yang lemah. Hasil pengujian aktivitas antioksidan (metode DPPH) dari fraksi hasil partisi tujuh ekstrak kasar karang lunak berpotensi sebagai antioksidan dengan kategori kuat sampai lemah. Dari hasil penelitian dapat disimpulkan bahwa ekstrak karang lunak asal Teluk Palu berpotensi sebagai sumber antioksidan. Karang lunak di pesisir Desa Kabonga Besar didominasi oleh genus Sinularia. ABSTRACTThe antioxidants substances are important for human health. Soft corals have been known to produce compounds with a variety of structural and biological activities, including bioactive antioxidants. The aim of this research was to obtain information of soft coral bioprospection from Palu Bay as an antioxidant. The research included sampling, identification, extraction (maceration) of soft corals, screening of chemical constituents, antioxidant activity assay (DPPH's radical scavenger), and determination of IC 50 . Soft coral samples were collected from Palu Bay, coastal village of Kabonga Besar, Donggala District, Central Sulawesi. Based on the shape of the monomorphic colony, seven soft coral samples that were used in this study belong to the genus Sinularia, Dampia and Sarcophyton. Analysis of chemical constituents indicated the presence of saponin compounds, phenolics, triterpenoids, and alkaloids. The results of the antioxidant activity by DPPH method showed that soft coral crude extracts have a weak percentage of DPPH's radical inhibition, while the results of the fraction had potential to be antioxidants with strong to weak categories. From the results of this study, it concluded that the soft coral extracts from Palu Bay have the potential as a source of antioxidants. The genus Sinularia dominates soft coral on the coast of Kabonga Besar Village.

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New Xenia Diterpenoids from the Indonesian Soft CoralXeniasp.

Abstract: Two new xeniolides, xeniolide-F (1) and 9-hydroxyxeniolide-F (2), along with isoxeniolide-A (3) and 7,8-oxido-isoxeniolide-A (4), have been isolated from Xenia sp. and their structures established on the basis of extensive NMR and MS studies.

Cited by 41 publications

References 11 publications

Marine natural products

Marine natural products

Induction of Apoptosis by Diterpenes from the Soft Coral Xenia elongata

Aktivitas Antioksidan Ekstrak Karang Lunak Asal Teluk Palu, Sulawesi Tengah, Indonesia

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