New Viral Agents Recovered From Tissue Cultures of Monkey Kidney Cells

Epidemiology of Myxo-Paramyxovirus Infections Among Cynomolgus Monkeys Imported for Laboratory Use

“…With regard to SV5 virus infection, many laboratories have experienced contamination of monkey kidney primary cell cultures with this virus (Hull et al, 1956;Emery and York, 1960;Yoshida et al, 1965;Hsiung and Atoynatan, 1966). Many investigators reported that antibodies to those viruses were seldom or never present in newly captured monkeys (Hsiung, Isacson and McCollum, 1962;Shah and Southwick, 1965;Tribe, 1966;Kalter et al, 1967;Shah and Morrison, 1969).…”

“…There are many reports on latent virus infections in cultured cells derived from nonhuman primates and on incidence of virus infections among monkeys and apes in captivity (Hull, Minner and Smith, 1956;Hull, Minner and Mascoli, 1958;Emery and York, 1960;Churchill, 1963;Yoshida, Yamamoto and Shimojo, 1965;Hsiung and Atoynatan, 1966;Tribe, 1966;Atoynatan and Hsiung, 1969). However, we know only little when animals are infected with those viruses, before or after capture.…”

STUDIES ON THE BIOLOGICAL PROPERTIES AND CLASSIFICATION OF SV4 VIRUS

“…The inhibitory effect of normal sera from certain animals on the growth of SV4 virus has been demonstrated (9,22). Similar experiments with newborn calf serum in the overlay medium showed a complete inhibition of plaques.…”

“…Hull et al (9,10,11) have not only isolated a large number of such viruses from kidney cell cultures of rhesus and cynomologus monkey, but also collected many isolates from other sources t o be tested and placed in a n informal grouping of viruses, the "Simian viruses" (SV).…”

“…Hull et al (9) first reported the virus in 1956 and placed i t in their group I11 on the basis of the gross cytopathological changes produced by SV4 virus in kidney cell cultures of rhesus monkey. Repeated attempts by these workers to classify the virus further, antigenically, met with failure, mainly because of the presence of a n inhibitory factor(s) in normal sera from many animal species.…”