Epidemiology of Myxo-Paramyxovirus Infections Among Cynomolgus Monkeys Imported for Laboratory Use

Nishikawa, Fumio; Sugiyama, Teiji; Takasaka, Masao; Honjo, Shigeo

doi:10.7883/yoken1952.27.249

Cited by 4 publications

(3 citation statements)

References 14 publications

(9 reference statements)

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“…BHK, MDCK and Vero cells were maintained in Eagle’s minimum essential medium (MEM) supplemented with 5% foetal calf serum (FCS). The T1 (Azetaka & Konishi, 1988 ) and WR (Nishikawa et al , 1974 ; Ito et al , 1997 ) strains of SV-5 were propagated in MDCK cells and stored at −80 °C. The virus titre (TCID 50 ) was determined by the haemadsorption method using Vero cells and sheep erythrocytes.…”

Section: Methodsmentioning

confidence: 99%

An amino acid in the heptad repeat 1 domain is important for the haemagglutinin–neuraminidase-independent fusing activity of simian virus 5 fusion protein

Ito

Nishio

Komada

et al. 2000

Journal of General Virology

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A canine isolate (strain T1) of simian virus 5 (SV-5) performed multiple replication in BHK cells but did not induce cell fusion for up to 3 days. In contrast, a prototype strain (WR) provoked extensive cell fusion within 2 days during the course of its replication. Accordingly, the fusion (F) protein of the T1 strain did not cause cell fusion even when co-expressed with the SV-5 haemagglutininneuraminidase (HN) protein, whereas the WR F protein induced cell fusion in the presence of the HN protein. Differences in the predicted amino acid sequences of the T1 and WR F proteins were found at 12 positions and it was proved that the T1 F protein had a longer cytoplasmic tail than the WR F protein. By reducing the length of the cytoplasmic tail or by replacing the tail with the WR F counterpart, the T1 F protein partly restored its HN-dependent fusing activity. Chimeric and mutational analyses between the T1 F protein and the mutant F protein (L22P) suggested that Glu-132 in the heptad repeat 1 domain was involved in the HN-independent fusing activity in addition to the previously identified Pro-22 at the F 2 N terminus. It was also shown that Ala-290 in the heptad repeat 3 domain contributed to the HN-independent fusing activity to some extent.

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Section: Methodsmentioning

confidence: 99%

An amino acid in the heptad repeat 1 domain is important for the haemagglutinin–neuraminidase-independent fusing activity of simian virus 5 fusion protein

Ito

Nishio

Komada

et al. 2000

Journal of General Virology

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“…We have been studying for several years myxo-and paramyxovirus infections, among human beings and nonhuman primates (Nishikawa et al, 1974). Wild birds have also been added to our studies as some species of birds seemed to play an important role in the epidemiology of human diseases due to these viruses.…”

Section: Isolation Of Influenza Type a Viruses From Imported Pet Birdsmentioning

confidence: 99%

Isolation of Influenza Type a Viruses From Imported Pet Birds

Nishikawa¹,

Sugiyama²,

Yamamoto³

et al. 1977

JJMSB

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“…These three viruses were selected from the following reasons. Firstly, SV5 could be regarded as an indicator for estimating the degree of contaminations with viruses of simian origin, since this virus has been known to be one of the most prevalent viruses among macaque monkeys (Yoshida et al, 1965;Tribe, 1966;Atoynatan and Hsiung, 1969;Nishikawa et al, 1974). Secondly, MV infection is a serious problem when wild-originated macaques are used for measles vaccine assay (Yamanouchi et al, 1969;Remfry, 1976;MacArthur et al, 1979), since this virus can easily be transmitted among non-immune monkeys of a group during transportation from habitat area to a user's facility even if the group has only one MV-infected monkey at first.…”

Section: Introductionmentioning

confidence: 99%

Serological Survey for Sv5, Measles and Herpes Simplex Infections in Newly-Imported Cynomolgus Monkeys

Suzuki

Sasagawa

Inayoshi

et al. 1981

JJMSB

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SUMMARY: On 592 cynomolgus monkeys of newly-imported 14 different groups, sero-epidemiological follow-up surveys of natural infections with SV5, measles (MV) and herpes simplex (HSV) were conducted both at the time of arrival and at the end of the 9-week quarantine period at Tsukuba Primate Center for Medical Science (TPC).At the time of arrival, the positive rate of antibodies against these viruses greatly varied with different countries of origin. As regards SV5, the positive rate ranged widely from 0 to 94.9% among different import-groups, being markedly low in the Philippine monkey groups. The positive rate of MV antibody was generally very high, varying from 11.1 to 78.2% in almost all import-groups except two groups from Indonesia in which no positive case was detected. Concerning HSV, every import-group had a very high positive rate though the average antibody titer was not so high.Generally, the positive rates of SV5 and MV markedly increased by the end of quarantine period. Especially, MV positive rate reached 100% in almost all of the import-groups.However, two Indonesian groups showed no increase of SV5 and MV positive rates during the quarantine period. No increase of SV5 positive rate was detected either with any of three Philippine groups. As for HSV, the positive rate remained unchanged or rather decreased during the quarantine period in almost all groups except two Indonesian groups having shown a significant increase.

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Epidemiology of Myxo-Paramyxovirus Infections Among Cynomolgus Monkeys Imported for Laboratory Use

Cited by 4 publications

References 14 publications

An amino acid in the heptad repeat 1 domain is important for the haemagglutinin–neuraminidase-independent fusing activity of simian virus 5 fusion protein

An amino acid in the heptad repeat 1 domain is important for the haemagglutinin–neuraminidase-independent fusing activity of simian virus 5 fusion protein

Isolation of Influenza Type a Viruses From Imported Pet Birds

Serological Survey for Sv5, Measles and Herpes Simplex Infections in Newly-Imported Cynomolgus Monkeys

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