Serological Survey for Sv5, Measles and Herpes Simplex Infections in Newly-Imported Cynomolgus Monkeys

Abstract

SUMMARY: On 592 cynomolgus monkeys of newly-imported 14 different groups, sero-epidemiological follow-up surveys of natural infections with SV5, measles (MV) and herpes simplex (HSV) were conducted both at the time of arrival and at the end of the 9-week quarantine period at Tsukuba Primate Center for Medical Science (TPC).At the time of arrival, the positive rate of antibodies against these viruses greatly varied with different countries of origin. As regards SV5, the positive rate ranged widely from 0 to 94.9% among different import-groups, being markedly low in the Philippine monkey groups. The positive rate of MV antibody was generally very high, varying from 11.1 to 78.2% in almost all import-groups except two groups from Indonesia in which no positive case was detected. Concerning HSV, every import-group had a very high positive rate though the average antibody titer was not so high.Generally, the positive rates of SV5 and MV markedly increased by the end of quarantine period. Especially, MV positive rate reached 100% in almost all of the import-groups.However, two Indonesian groups showed no increase of SV5 and MV positive rates during the quarantine period. No increase of SV5 positive rate was detected either with any of three Philippine groups. As for HSV, the positive rate remained unchanged or rather decreased during the quarantine period in almost all groups except two Indonesian groups having shown a significant increase.

THE PLACENTAL TRANSFER OF IgG IN THE CYNOMOLGUS MONKEY

“…Anti-streptolysin O activity was determined with the streptolysin O reagent (Wako Co., Osaka). The hemagglutination inhibition (HI) antibody titer to measles virus was determined by the procedure described previously by Suzuki et al (1981). age.…”

Age-Related Immunoglobulin Levels in Cynomolgus Monkeys

“…In addition, anti-measles antibody (HI titer) as a typical example of transplacentally transmitted IgG was measured with 93 infant monkeys at 0 day to 1.5 years of age by the method described elsewhere (Suzuki et al, 1981 Figure 3 presents the hemagglutination inhibition (HI) titers of measles antibody in 93 infant monkeys. The HI titer showed its highest level at birth and declined to an undetectable level by 6 months of age.…”

Herpes Simplex Virus Complement Fixing Antibody and Herpes B Virus Serum Neutralizing Antibody in Sera of Wild and Laboratory-bred Cynomolgus Monkeys

“…Furthermore, our previous data [12] revealed little increase in the HSV infection rate among newly imported cynomolgus monkeys during the quarantine period of at least 9 weeks.…”