New Vanadium(V) Complexes with Salicylaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and in vitro Insulin‐Mimetic Activity − Crystal Structure of [V^vO₂(salicylaldehyde semicarbazone)]

Abstract

The new dioxo(semicarbazone)vanadium(V) complexes cis-VO 2 L, where L = salicylaldehyde semicarbazone (L 1 ), salicylaldehyde 4-n-butylsemicarbazone (L 2 ), or salicylaldehyde 4-(2-naphthyl)semicarbazone (L 3 ), have been synthesized, characterized by 1 H and 13 C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO 2 L 2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel

DNA binding and photocleavage properties of two mixed-ligand oxovanadium complexes

“…However, little attention has been paid to the interactions of vanadyl complexes with DNA. A few oxovanadium complexes bearing salicylidene dithiosemicarbazone, VO(salmdtc)(phen), VO(salmdtc)(dpq) and VO(salmdtc)(dppz) have been synthesized and studied for their DNA binding and cleavage activities [21]. Nevertheless, the mechanisms by which they interact with biological molecules have not been clearly elucidated yet [16][17][18][19][20].…”

“…DNA-binding metal complexes, especially those with small molecular weight, have been extensively studied as DNA structural and conformational probes, DNA-dependent electron transfer and sequence-specific cleaving agents, and potential anticancer drugs [4][5][6]. As a trace bioelement existing in the human body, vanadium has been found to present a variety of biological activities such as antitumor, antimicrobial and insulin-enhancing effects, and its complexes have therefore been widely studied in order to promote these pharmacological effects and concomitantly reduce toxicity [7][8][9][10]. Because of their wide range of pharmacological applications, thiosemicarbazones were often chosen as such ligands for vanadium [11][12][13][14].…”

Dioxovanadium(V) Complexes Incorporating Tridentate ONO Donor Hydrazone Ligands Derived from Acetylhydrazide and 2-hydroxybenzaldehyde/2-hydroxyacetophenone. Synthesis, Characterization and Reactivity

“…The reactivity of these complexes with ascorbic acid and a phenolic compound (e.g., 8-hydroxyquinoline) has been studied. Most of the reported dioxovanadium complexes have been prepared starting from the VO 3+ precursor (e.g., vanadate ester) [13][14][15][16][17][18] and a few complexes using [V IV O(acac) 2 ] [19][20][21][22][23] in methanol or in ethanol or in acetonitrile medium. To the best of my knowledge only one reported complex was synthesized from an aqueous-alcoholic medium using VOSO 4 as the precursor and N-salicylidene-N¢-(2-hydroxyethyl) ethylenediamine (H 2 SHED) as the ligand [24].…”

Synthesis and Conjoint Experimental-DFT Characterization of Some Pyrazolone Functionalized Dioxovanadium (V) Schiff Base Complexes

“…A variety of semicarbazones and their metal complexes have been reported to possess properties of wide variation in their stereochemistry and modes of bonding through oxygen and azomethine nitrogen atoms [14]. The metal binding properties in semicarbazones are tailored and appended by tagging with different additional donor atoms involving substituted aldehydes or ketones [18][19][20][21] witnessed by a number of reports of the same field of investigation [22][23][24]. Vanadium (V) complexes have been shown to ensue stereo-chemically flexible coordination geometries [25].…”