New Ultrasound Measurements to Bridge the Gap between Prenatal and Neonatal Brain Growth Assessment

Koning, Irene; Roelants, Jorine; Groenenberg, Irene A.L.; Vermeulen, Marijn J.; Willemsen, Sten P.; Govaert, Paul; Steegers‐Theunissen, R.P.M.; Dudink, Jeroen

doi:10.3174/ajnr.a5278

Cited by 13 publications

(24 citation statements)

References 32 publications

(39 reference statements)

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“…Similarly, a 3D ultrasound study was performed to establish CC growth trajectories where prenatal (22,26, and 32 weeks' GA) and postnatal (42 weeks' GA) ultrasounds were done. CC and CCF growth trajectories were significantly decreased in FGR fetuses compared to normal controls [11]. Our study findings are similar to the results of both these studies.…”

Section: Discussionsupporting

confidence: 91%

“…CC length was measured from the genu to the splenium, outer-outer border. CCF length represents the length between the genu of the CC and the fastigium (roof of the fourth ventricle) [11]. The anterior horn width (AHW) and ventricular index (VI) of the lateral ventricles were measured in a coronal view, with the plane of the scan at the level of the interventricular foramen of Monro.…”

Section: Methodsmentioning

confidence: 99%

“…Similar studies using cranial ultrasound for estimating measurements of different brain structures are lacking. Ultrasound studies have described the effect of SGA on growth of brain structures such as cerebellar vermis height (VH) [10], CC, and CC fastigium (CCF) length [11] in isolation. No studies have been performed looking at the impact of "brain sparing" effect in FGR neonates with fetal cerebral redistribution.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound Measurements of Intracranial Structures in Growth-Restricted Neonates with Fetal Blood Flow Redistribution: A Pilot Observational Study

et al. 2020

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Background: Fetal growth restriction (FGR) is associated with neonatal and long-term neuro-morbidity. Preferential redistribution of blood flow to the brain is a common antenatal adaptation in FGR. The impact of this “brain sparing,” which may signify severity of FGR, on the growth of brain structures has not been studied. Aim: To compare corpus callosum (CC), cerebellar, and ventricular measurements of FGR neonates with evidence of fetal blood flow redistribution with those of gestation-matched appropriately grown (AGA) neonates. Methods: This was a pilot, prospective observational study conducted at a tertiary level neonatal unit in Melbourne, Australia. Cranial ultrasound was done between days 1 and 3 of life in FGR and AGA neonates. Results: Cranial ultrasound on 20 FGR, gestation (mean ± SD) 31.4 ± 3.1 weeks, weight 1,205 ± 463 g, and 20 AGA neonates, 31.1 ± 3.0 weeks, 1,668 ± 490 g, was performed. CC length was significantly decreased in FGR neonates as compared to AGA neonates (35.28 ± 3.47 vs. 38.83 ± 4.05 mm, p = 0.0002). CC was significantly thinner at genu (3.36 ± 0.66 vs. 4.04 ± 0.83 mm, p = 0.007), body (1.97 ± 0.36 vs. 2.27 ± 0.39 mm, p = 0.02), and splenium (4.07 ± 0.76 vs. 4.72 ± 0.75 mm, p = 0.003) in FGR vs. AGA neonates. CC-fastigium length was also significantly decreased (39.65 ± 3.87 vs. 41.96 ± 4.50 mm, p = 0.04). Similarly, FGR neonates showed decreased transverse cerebellar diameter (36.15 ± 5.51 vs. 38.81 ± 7.21 mm, p = 0.02), but ventricular measurements were comparable. In multivariate analysis, these differences were evident independent of the birth weight. Conclusions:CC and cerebellar measurements are significantly smaller in FGR neonates with fetal blood flow redistribution, which warrants further study.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ultrasound Measurements of Intracranial Structures in Growth-Restricted Neonates with Fetal Blood Flow Redistribution: A Pilot Observational Study

et al. 2020

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“…[ 15 , 16 ] There are, to the best of our knowledge, few publications on CC morphologic reference data for neonates. Koning et al [ 5 ] combined fetal and neonatal ultrasonography markers for the CC into a single cohort and created a continuum for monitoring brain growth. Results from Koning et al confirmed the feasibility and reliability of cranial ultrasonography, while their attempt was to bridge the gap between prenatal and cranial ultrasonography, only one morphological parameter of CC was evaluated in their study.…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 ] Nevertheless, this technique can lead to misdiagnoses as it is difficult to display a standard midsagittal plane, especially when the fetus is not in a proper position. In a recent study by Koning et al, [ 5 ] the success rate reportedly ranged between 61% and 75% for the measurement of CC length in fetuses. The authors also conducted cranial ultrasonography (CUS) in the same cohort after birth; the success rate was 97%, which was much higher than that obtained during prenatal assessment.…”

Section: Introductionmentioning

confidence: 99%

Biometry reference range of the corpus callosum in neonates

Gao

Yang²,

Yang³

et al. 2018

Medicine

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This study aims to present the reference range of corpus callosum by ultrasound imaging in neonates and to develop a clinically feasible screening method for congenital abnormalities of corpus callosum.An observational study was conducted between January 2015 and July 2016; 2D and 3D ultrasound evaluations were conducted and virtural organ computer-aided analysis was applied in the volume calculation of corpus callosum. The following parameters were measured: thickness of the rostum, thickness of the genu, thickness of the body, thickness of the splenium, anterior–posterior distance, true length of the corpus callosum and the volume of the corpus callosum. Inter- and intraobserver agreement was also evaluated. The corrected gestational age was between 38+0 and 47+2 weeks. The least-mean-square method was used to create the growth curve for each parameter.Complete data sets were available in 317 neonates, ranging from 0 to 28 days of age. Reference values from the 1st to 99th percentiles were provided. All parameters showed a nonlinear growth trend with age. Inter- and intraobserver agreement was excellent for 2D and 3D parameters.Our results suggested that computer techniques can assist in the volume assessment of corpus callosum. The 2D and 3D ultrasound data of 7 morphologic parameters may facilitate the identification of corpus callosum anomalies based on a large population.

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Neurosonographic assessments of corpus callosum related structures in growth‐restricted fetuses

Yakıştıran

Altınboğa

Öztürk

et al. 2021

J of Clinical Ultrasound

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The aim of this study was to evaluate whether corpus callosum length (CCL), corpus callosum-fastigium length (CCFL) and the angle between CCL-CCFL (CCFA) were altered in growth-restricted fetuses.Methods: This prospective case-control study was conducted in a tertiary center. A total of 80 singleton fetuses were included in the study, classified as 36 late-onset growth-restricted fetuses and 44 adequate-for-gestational-age fetuses. All biometric measurements and Doppler assessments of umbilical artery, middle cerebral artery, and ductus venosus were performed via the trans-abdominal route. CCL, CCLF, and CCFA were assessed via the trans-vaginal route.Results: Late-onset growth-restricted fetuses showed significantly reduced CCL and CCFL. There was no statistically significant differences in terms of CCFA. Moderatehigh correlations between CCL and biparietal diameter, head circumference, abdominal circumference, FL and gestational age were detected (r

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New Ultrasound Measurements to Bridge the Gap between Prenatal and Neonatal Brain Growth Assessment

Cited by 13 publications

References 32 publications

Ultrasound Measurements of Intracranial Structures in Growth-Restricted Neonates with Fetal Blood Flow Redistribution: A Pilot Observational Study

Ultrasound Measurements of Intracranial Structures in Growth-Restricted Neonates with Fetal Blood Flow Redistribution: A Pilot Observational Study

Biometry reference range of the corpus callosum in neonates

Neurosonographic assessments of corpus callosum related structures in growth‐restricted fetuses

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