Biometry reference range of the corpus callosum in neonates

Gao, Yongxing; Yang, Kai; Yang, Lin; Cheng, Guoqiang; Zhou, Wenhao

doi:10.1097/md.0000000000011071

Cited by 4 publications

(5 citation statements)

References 25 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lateral ventricles were noted to be prominent and there was a cavum septum pellucidum et vergae. The corpus callosum was thicker than expected for patient age and gender (Gao et al, 2018). Nodules of gray matter heterotopia were seen in the cerebellum (Figure 1).…”

Section: Investigationsmentioning

confidence: 75%

An in‐frame deletion affecting the critical acid loop of PPP2R5D is associated with a neonatal lethal form of PPP2R5D‐related neurodevelopmental disorder

Alhajaj

Lacroix

Trakadis

et al. 2023

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Heterozygous pathogenic variants in PPP2R5D gene are associated with PPP2R5D‐related neurodevelopmental disorder, a rare autosomal dominant condition, characterized by neurodevelopmental impairment in childhood, macrocephaly/megalencephaly, hypotonia, epilepsy, and dysmorphic features. Up‐to‐date, only approximately 100 cases have been published in the literature and the full phenotypic and genotypic spectrum have not yet been fully described. PPP2R5D gene encodes the B56δ subunit of the PP2A enzyme complex. We describe a neonatal form of PPP2R5D‐related disorder with early infantile death, caused by a novel in‐frame deletion causing loss of 8 amino acids and insertion of serine at position 201 (p.Phe194_Pro201delinsSer) of the B56δ subunit. This deletion is predicted to disrupt a critical acidic loop of amino acids important for binding other subunits of the PP2A enzyme complex, and harbors many of the residues previously reported to cause a mild–moderate form of this condition. This report describes a neonatal lethal presentation of the PPP2R5D‐related neurodevelopmental disorder and provides additional evidence that disruption of the acidic loop is an important pathomechanism underlying PPP2R5D‐related disorder.

show abstract

Section: Investigationsmentioning

confidence: 75%

An in‐frame deletion affecting the critical acid loop of PPP2R5D is associated with a neonatal lethal form of PPP2R5D‐related neurodevelopmental disorder

Alhajaj

Lacroix

Trakadis

et al. 2023

American J of Med Genetics Pt A

View full text Add to dashboard Cite

show abstract

“…Also of note, unlike adults with CC injury and pediatric patients with developmental anomalies of the CC who commonly exhibit cognitive impairments, language delay, visuospatial integration issues, dyslexia, and behavioral issues, newborn infants with penetrating CC injury did not show impairments in the cognitive and motor domains. 7,22,31,32 We speculate that this may be reflective of the higher neuroplastic capacity of the developing human brain. It is also possible that cognitive impairments may first become apparent later in childhood when the cognitive demands increase at school age.…”

Section: Discussionmentioning

confidence: 86%

Corpus callosum injury after neurosurgical intervention for posthemorrhagic ventricular dilatation and association with neurodevelopmental outcome at 2 years

Cizmeci

Groenendaal

et al. 2022

Journal of Neurosurgery: Pediatrics

View full text Add to dashboard Cite

OBJECTIVE Direct injury to the corpus callosum (CC) due to neurosurgical interventions in infants with posthemorrhagic ventricular dilatation (PHVD) has not been reported in the literature. The authors observed a subset of infants who had suffered penetrating CC injury after neurosurgical interventions for PHVD and hypothesized that this pattern of injury may result in suboptimal CC maturation and neurodevelopmental impairment. METHODS In this multicenter, retrospective, observational study, 100 preterm and 17 full-term infants with PHVD were included and compared with 23 preterm controls. Both neonatal and postneonatal brain MRI scans were assessed for injury, and measurements were performed on postneonatal MRI scans at 2 years’ corrected age. Neurodevelopmental outcome was assessed at 2 years’ corrected age. RESULTS A total of 269 brain MRI scans of 140 infants were included. Of infants with PHVD, 48 (41%) had penetrating CC injury following neurosurgical interventions. The median (IQR) CC midsagittal surface area was smaller in infants with CC injury when compared with infants with PHVD who had intact CC and controls (190 mm2 [149–262 mm2] vs 268 mm2 [206–318 mm2] vs 289 mm2 [246–320 mm2], respectively; p < 0.001). In the univariate analysis, the area of the CC was associated with cognitive Z score (coefficient 0.009 [95% CI 0.005–0.012], p < 0.001) and motor Z score (coefficient 0.009 [95% CI 0.006–0.012], p < 0.001). In the multivariable model, CC injury was not independently associated with cognitive and motor Z score after adjusting for gestational age and presence of periventricular hemorrhagic infarction (coefficient 0.04 [95% CI −0.36 to 0.46] and −0.37 [95% CI −0.83 to 0.09], p = 0.7 and 0.1, respectively). CONCLUSIONS CC injury was not uncommon following neurosurgical interventions for PHVD in both preterm and full-term infants. At the age of 2 years, the CC midsagittal surface area was smaller in infants with injury, but CC injury was not independently associated with cognitive and motor outcomes at 2 years’ corrected age.

show abstract

“…This study provides easily applicable and reproducible MR imaging biometry data of the CC in children, offering reference values and growth patterns for each parameter, thus contributing to practical clinical use. Gao Y., et.al;(2018) 15 : This study aims to establish a reference range for the corpus callosum using ultrasound imaging in neonates and to develop a clinically feasible screening method for congenital abnormalities of the corpus callosum. Methods: An observational study was conducted from January 2015 to July 2016, involving 2D and 3D ultrasound evaluations.…”

Section: Resultsmentioning

confidence: 99%

“…In this comprehensive review on MRI role in corpus callosum measurement have reviewed on many research articles and the outcome about corpus callosum measurement have to variation in length of corpus callosum at different age groups between both sexes. We compare the reviewed outcome with some different authors study Weis S. et.al; (1993), 7 Rajapkase J. et.al; (1996), 8 Dorion A. et.al; (2001), 9 Chiara N. et.al; (2004), 10 Van K. et.al; (2008), 11 Rizzo G. et.al; (2011), 12 Mohammad M. et.al; (2011), 13 Garel C. et.al; (2011), 14 Gao Y. et.al; (2018), 15 Kamal A. et.al; (2019), 16 Ping J. et.al; (2020), 17 Gnawali S. et.al; (2021), 18 Berman S. et.al; (2018), 19 Bayar O. et.al; (2021). 20 Their parameter was significant and population have variation in length of corpus callosum at different age group between both sexes.…”

Section: Discussionmentioning

confidence: 99%

A comprehensive review on role of magnetic resonance imaging in the precise measurement of corpus callosum

Singh,

Shmriti,

Kumar

2024

IJASHNB

View full text Add to dashboard Cite

Magnetic Resonance Imaging (MRI) has emerged as a powerful and non-invasive imaging technique, playing a pivotal role in neuroimaging research and clinical diagnosis. This comprehensive review explores the significance of MRI in the precise measurement of the corpus callosum, a key structure connecting the two hemispheres of the brain. The corpus callosum plays a crucial role in inter hemispheric communication and is implicated in various neurological and psychiatric disorders. The review begins by elucidating the anatomy and functions of the corpus callosum, emphasizing its importance in facilitating seamless communication between the cerebral hemispheres. Subsequently, the paper delves into the historical evolution of MRI techniques and how advancements have enhanced the visualization and measurement capabilities of the corpus callosum. A detailed examination of various MRI modalities, including structural MRI, diffusion tensor imaging (DTI), and functional MRI, is presented in the context of corpus callosum analysis. Structural MRI provides high-resolution images for accurate morphological assessments, while DTI offers insights into white matter microstructure and fiber tractography, allowing for a more comprehensive understanding of the corpus callosum's integrity. The review also highlights the role of MRI in investigating alterations in the corpus callosum associated with neurological disorders such as multiple sclerosis, epilepsy, and neurodevelopmental disorders. Additionally, the paper explores how functional MRI contributes to understanding the functional connectivity and inter hemispheric interactions mediated by the corpus callosum. Challenges and limitations in the measurement of the corpus callosum using MRI are discussed, including methodological considerations, image artifacts, and potential sources of variability. The review concludes by outlining future directions in corpus callosum imaging research, including the integration of advanced imaging techniques, artificial intelligence, and large-scale multi-center studies to enhance the precision and reliability of measurements.In summary, this comprehensive review underscores the pivotal role of MRI in advancing our understanding of the corpus callosum, providing valuable insights into both normal brain function and pathological conditions. The continual evolution of MRI techniques holds promise for further refining the assessment of the corpus callosum, ultimately contributing to improved diagnostic accuracy and therapeutic interventions in neurological and psychiatric disorders.

show abstract

Biometry reference range of the corpus callosum in neonates

Cited by 4 publications

References 25 publications

An in‐frame deletion affecting the critical acid loop of PPP2R5D is associated with a neonatal lethal form of PPP2R5D‐related neurodevelopmental disorder

An in‐frame deletion affecting the critical acid loop of PPP2R5D is associated with a neonatal lethal form of PPP2R5D‐related neurodevelopmental disorder

Corpus callosum injury after neurosurgical intervention for posthemorrhagic ventricular dilatation and association with neurodevelopmental outcome at 2 years

A comprehensive review on role of magnetic resonance imaging in the precise measurement of corpus callosum

Contact Info

Product

Resources

About