New Type of Allergic Asthma due to IgG "Reaginic" Antibody

Abstract

pronounced over three-hour procedures, and appears proportional to the degree of manual activity within the team.There is no doubt that palmar sweat contains a variety of substances capable of inactivating iodine. Unless the Disadine scrub is followed by a continuous release of available iodine throughout the operative procedure, failure to deal with recolonizing skin bacteria may be expected. This hypothesis is the subject of further studies.The dominance of right and left hand contamination of surgeon and scrub-nurse respectively remains an unexplained observation. It was not due to a majority of left-handed nurses. In an earlier study in this unit Davidson (1969) showed glove puncture to occur most commonly on the left hand of the surgeon and the right hand of the scrub-nurse. This was thought to be due to the different way in which they handled suture needles. In the current trial the glove puncture rate remained constant throughout. Medical3Journal, 1973, 4, 589-592 Summary This study was undertaken to examine the possibility that IgE is not the only immunoglobulin respdnsible for immediate allergic reactions. A group of asthmatics were investigated in whom immediate allergic reactivity of the bronchi to common inhalant allergens had been confirmed by provocation tests. Their sera were fractionated and the reaginic activity of the immunoglobulin classes was studied by passive cutaneous anaphylaxis testing in monkeys. The results showed that the immediate allergic reactions were due to IgE antibodies in most patients, but there was a group with reactions due to shortterm anaphylactic IgG antibodies. It was not possible to inhibit the IgG-mediated responses with disodium cromoglycate. As these two groups had clearly different serum IgE levels the estimation of IgE provided an important guide to the management of these patients. Conclusion

PROTECTIVE EFFECTS OF THE GLUCOCORTICOID, BUDESONIDE, ON LUNG ANAPHYLAXIS IN ACTIVELY SENSITIZED GUINEA‐PIGS: INHIBITION OF IgE — BUT NOT OF IgG — MEDIATED ANAPHYLAXIS

“…However, mast cells and basophils from different species also possess Fcreceptors for homocytotropic antibodies of the IgGclass (Spiegelberg, 1974) and there are reports indicating different receptors for IgG and IgE on mast cells (Daeron, Pronovost-Danon & Voison, 1980;Moodley & Mongar, 1981). Although there are reports of anaphylactic antibodies of the IgG-type in man (Bryant, Burns & Lazarus 1973;1975), the pathophysiological importance of IgG-mediated reactions for human asthma symptoms is not clear. Thus in an animal model it would be desirable to obtain a type I anaphylactic response mediated by IgE-like antibodies.…”

Effects of Inhibitors of Anaphylactic Mediators in Two Models of Bronchial Anaphylaxis in Anaesthetized Guinea‐pigs

“…The anaphylactic response mediated by antibodies of the IgG-type has been far less investigated. There are reports of anaphylactic antibodies of the IgG-type in asthmatics (Bryant, Burns & Lazarus, 1973;1975). However, the pathophysiological importance of the IgG antibodymediated reactions for human asthma is not clear (Ishizaka & Ishizaka, 1973).…”

Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Effect of Long‐term Treatment With Sodium Cromoglycate and Aminophylline

“…There are reports indicating involvement of IgG antibodies in the release of anaphylactic mediators in man but their role in the pathogenesis of atopic diseases like asthma is controversial (Bryant, Burns & Lazarus, 1973;. Andersson (1980a;1981) showed that guinea-pigs sensitized with low doses of antigen together with Al(OH)3 as an adjuvant (procedure a) produce both IgE-and IgG-like antibodies whereas those sensitized with high doses of antigen without adjuvant (procedure b) produce IgG-like antibodies.…”