New triterpenoid saponins from the whole plants of Clematis heracleifolia

Zhang, Qian; Lu, Yang; Liu, Yang; Tang, Hai‐Feng

doi:10.1016/j.fitote.2022.105179

Cited by 3 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(See Supplementary Figure S51) It is well known that the linkage of the sugar moieties, as well as their number and nature, are very important for the cytotoxicity of triterpenoid saponins [25]. The previous results on the cytotoxicity of triterpenoid saponins against various cancer cell lines showed that the C-3,28-bidesmosides were noncytotoxic, in most cases, compared to the C-3 ones [25,28,29]. Additionally, the work conducted by Lee et al (2002) [25] revealed that the linkages of sugars at the C-28 of echinocystic acid are essential for the non-cytotoxicity trait.…”

Section: Resultsmentioning

confidence: 98%

Echinocystic Acid Bidesmoside Saponins from Microglossa afzelii O. Hoffm and Their Cytotoxic Activity against the CAL-27 Oral Squamous Carcinoma Cell Line

et al. 2022

View full text Add to dashboard Cite

This paper describes eight new triterpenoid saponins, including afzeliioside A (1), four acetylated afzeliiosides as pairs of inseparable regioisomers, called afzeliiosides B/C (2/3) and D/E (4/5), afzeliiosides F-H (6−8), and a known impatiprin C (9), which were isolated from the n-BuOH fraction of the liana of Microglossa afzelii. Their structures were established mainly by extensive spectroscopic analysis, including 1D and 2D NMR, HRFAB-MS, tandem ESI-MS/MS, and chemical methods, as well as a comparison of their spectral data with those of related compounds. All the isolates were screened for their cytotoxic activity against the CAL-27 oral squamous carcinoma cell line. Only compounds 4/5 (EC50 = 36.0 µg/mL (32.7 µM)) exhibited moderate cytotoxic activity. This work presents the first chemical and biological investigation of Microglossa afzelii and reports, for the first time, on the isolation of saponins in the genus Microglossa.

show abstract

Section: Resultsmentioning

confidence: 98%

Echinocystic Acid Bidesmoside Saponins from Microglossa afzelii O. Hoffm and Their Cytotoxic Activity against the CAL-27 Oral Squamous Carcinoma Cell Line

et al. 2022

View full text Add to dashboard Cite

show abstract

A novel flavonol glycoside and six derivatives of quercetin and kaempferol from Clematis flammula with antioxidant and anticancer potentials

Medjahed,

Chaher-Bazizi,

Atmani-Kilani

et al. 2023

Fitoterapia

View full text Add to dashboard Cite

A Comprehensive insight into the phytoconstituents and health benefits of Clematis species

Thapliyal,

Sati,

Sati

2024

ECJ

View full text Add to dashboard Cite

The genus of Clematis is a buttercup family (Ranunculaceae), recognized for its flowers and adaptable as an ornamental plant in colder climates. It contains around 300 species. Clematis has a variety of active phytoconstituents or secondary metabolites which are responsible for health benefits in human beings. Traditionally various species of the clematis genus used for centuries to treat various ailments including syphilis, bone disorders, gout, rheumatism, diuretics, wound healing, blood sugar control, blood diseases, spleen difficulties, leprosy, fevers, skin diseases. A systematic review of scientific electronic database and reference books were consulted to find all relevant literature for this work. This review discusses the ethno-medicinal usage, health advantages, phytoconstituents and bioactivities of clematis species.

show abstract

New triterpenoid saponins from the whole plants of Clematis heracleifolia

Cited by 3 publications

References 26 publications

Echinocystic Acid Bidesmoside Saponins from Microglossa afzelii O. Hoffm and Their Cytotoxic Activity against the CAL-27 Oral Squamous Carcinoma Cell Line

Echinocystic Acid Bidesmoside Saponins from Microglossa afzelii O. Hoffm and Their Cytotoxic Activity against the CAL-27 Oral Squamous Carcinoma Cell Line

A novel flavonol glycoside and six derivatives of quercetin and kaempferol from Clematis flammula with antioxidant and anticancer potentials

A Comprehensive insight into the phytoconstituents and health benefits of Clematis species

Contact Info

Product

Resources

About