New triterpene and nor-diterpene derivatives from the leaves of Adinandra poilanei

Oanh, Vũ Thị Kim; Hà, Nguyễn Thị Thu; Ho, Duc Viet; Ngoc, Thuc Dinh; Hang, Nguyen Thi Minh; Le, Thanh Nguyen

doi:10.1016/j.phytol.2021.10.003

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…An assay for the α -glucosidase inhibitory activity was carried out by a modification of the published method [ 26 ]. Briefly, solutions of α -glucosidase ( Saccharomyces cerevisiae , G0660, Sigma-Aldrich, St. Louis, MO, USA) and p -nitrophenyl α -D-glucopyranoside (Sigma-Aldrich, St. Louis, MO, USA) were prepared in a phosphate buffer (100 mM, pH 6.8, Sigma-Aldrich, St. Louis, MO, USA).…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial, Cytotoxic, and α-Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from Homotrigona apicalis Propolis—In Vitro and Molecular Docking Studies

Phuong

Tuan

et al. 2023

Life

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The chemical investigation of Homotrigona apicalis propolis collected in Binh Dinh province, Vietnam, led to the isolation of nine compounds, including four sesquiterpenes: spathulenol (1), 1αH,5βH-aromandendrane-4β,10α-diol (2), 1β,6α-dihydroxy-4(15)-eudesmene (3), and 1βH,5βH-aromandendrane-4α,10β-diol (4); three triterpenes: acetyl oleanolic acid (5), 3α-hydroxytirucalla-8,24-dien-21-oic acid (6), and ursolic acid (7); and two xanthones: cochinchinone A (8) and α-mangostin (9). Sesquiterpens 1–4 and triterpene 6 were isolated for the first time from stingless bee propolis. Plants in the Cratoxylum and Aglaia genus were suggested as resin sources of the propolis sample. In the antibacterial activity evaluation, the EtOH extract only showed moderate activity on S. aureus, while the isolated compounds 7–9 showed good antibacterial activity, with IC50 values of 0.56 to 17.33 µg/mL. The EtOH extract displayed selective cytotoxicity against the A-549 cancer cell line, with IC50 values of 22.82 ± 0.86 µg/mL, and the xanthones 8 and 9 exhibited good activity against the KB, HepG-2, and A-549 cancer cell lines, with IC50 values ranging from 7.55 ± 0.25 µg/mL to 29.27 ± 2.07 µg/mL. The cytotoxic effects of xanthones 8 and 9 were determined by the inhibition of the EGFR and HER2 pathways using a molecular docking study. Compounds 8 and 9 displayed strong binding affinity with EFGR and HER2, with values of −9.3 to −9.9 kcal/mol. Compounds 5, 8, and 9 showed potential α-glucosidase inhibitory activities, which were further confirmed by computational studies. The binding energies of compounds 5, 8, and 9 were lower than that of arcabose.

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Section: Methodsmentioning

confidence: 99%

Antimicrobial, Cytotoxic, and α-Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from Homotrigona apicalis Propolis—In Vitro and Molecular Docking Studies

Phuong

Tuan

et al. 2023

Life

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“…Compound 2 showed a moderate inhibition, with IC 50 values of 282 μM, surpassing the efficacy of the positive control acarbose (1.33 mM) [ 2 ]. Compound 298 displayed significant inhibition, with an IC 50 value of 64.05 ± 1.59 μg/mL [ 100 ]. Compound 363 showed a moderate inhibition on α -glucosidase (IC 50 = 7.94 μM).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A Comprehensive Review of the Classification, Sources, Phytochemistry, and Pharmacology of Norditerpenes

Zeng,

Zhang,

Yao

et al. 2023

Molecules

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Norditerpenes are considered to be a common and widely studied class of bioactive compounds in plants, exhibiting a wide array of complex and diverse structural types and originating from various sources. Based on the number of carbons, norditerpenes can be categorized into C19, C18, C17, and C16 compounds. Up to now, 557 norditerpenes and their derivatives have been found in studies published between 2010 and 2023, distributed in 51 families and 132 species, with the largest number in Lamiaceae, Euphorbiaceae, and Cephalotaxaceae. These norditerpenes display versatile biological activities, including anti-tumor, anti-inflammatory, antimicrobial, and antioxidant properties, as well as inhibitory effects against HIV and α-glucosidase, and can be considered as an important source of treatment for a variety of diseases that had a high commercial value. This review provides a comprehensive summary of the plant sources, chemical structures, and biological activities of norditerpenes derived from natural sources, serving as a valuable reference for further research development and application in this field.

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Chemical constituents from the leaves of Viburnum odoratissimum and their chemotaxonomic significance

Chu,

Li,

Huang

et al. 2024

Biochemical Systematics and Ecology

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New triterpene and nor-diterpene derivatives from the leaves of Adinandra poilanei

Cited by 6 publications

References 19 publications

Antimicrobial, Cytotoxic, and α-Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from Homotrigona apicalis Propolis—In Vitro and Molecular Docking Studies

Antimicrobial, Cytotoxic, and α-Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from Homotrigona apicalis Propolis—In Vitro and Molecular Docking Studies

A Comprehensive Review of the Classification, Sources, Phytochemistry, and Pharmacology of Norditerpenes

Chemical constituents from the leaves of Viburnum odoratissimum and their chemotaxonomic significance

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