New Trends in the Biomanufacturing of Green Surfactants: Biobased Surfactants and Biosurfactants

Ramani, K.; Muneeswari, R.; Venkatesan, Swathi Krishnan; Uddin, Maseed

doi:10.1021/bk-2019-1329.ch011

Cited by 24 publications

(14 citation statements)

References 151 publications

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“…Hence, the use of nanotechnological methods to increase the production of GSs via microbial induction has been evaluated. A lot of research studies have been carried out on decreasing the cost sources for manufacturing GSs [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments

et al. 2021

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Encapsulation of the chemotherapy agents within colloidal systems usually improves drug efficiency and decreases its toxicity. In this study, lignin (LGN) (the second most abundant biopolymer next to cellulose on earth) was employed to prepare novel doxorubicin (DOX)-loaded oil-in-water (O/W) microemulsions with the aim of enhancing the bioavailability of DOX. The droplet size of DOX-loaded microemulsion was obtained as ≈ 7.5 nm by dynamic light scattering (DLS) analysis. The entrapment efficiency (EE) % of LGN/DOX microemulsions was calculated to be about 82%. In addition, a slow and sustainable release rate of DOX (68%) was observed after 24 h for these microemulsions. The cytotoxic effects of standard DOX and LGN/DOX microemulsions on non-malignant (HUVEC) and malignant (MCF7 and C152) cell lines were assessed by application of a tetrazolium (MTT) colorimetric assay. Disruption of cell membrane integrity was investigated by measuring intracellular lactate dehydrogenase (LDH) leakage. In vitro experiments showed that LGN/DOX microemulsions induced noticeable morphological alterations and a greater cell-killing effect than standard DOX. Moreover, LGN/DOX microemulsions significantly disrupted the membrane integrity of C152 cells. These results demonstrate that encapsulation and slow release of DOX improved the cytotoxic efficacy of this anthracycline agent against cancer cells but did not improve its safety towards normal human cells. Overall, this study provides a scientific basis for future studies on the encapsulation efficiency of microemulsions as a promising drug carrier for overcoming pharmacokinetic limitations.

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Section: Introductionmentioning

confidence: 99%

Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments

et al. 2021

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“…The latter includes additional purification steps that imply higher capital and operational costs and result in a higher cost of goods (Narasimhan et al, 2015; Sebastiani et al, 2021; Yang, 1980). In this context, the higher cost of fatty alcohol ethoxylates opens a window of opportunity for biobased surfactants to be more cost‐competitive and substitute fatty alcohol ethoxylates in household products and biocompatible formulations (Jackson et al, 2021; Kandasamy et al, 2019; Sreenu et al, 2015). Nevertheless, biobased surfactants present a distribution of different substances (due to the nature of fermentation reactions and the variability of feedstocks), making the formulation with such products more challenging (although more environmentally friendly) (Hayes & Smith, 2019).…”

Section: New Dioxane Regulations As An Opportunity For Biobased Surfa...mentioning

confidence: 99%

Surfactants produced from carbohydrate derivatives: A review of the biobased building blocks used in their synthesis

Ortiz

Alvarado

Zambrano³

et al. 2022

J Surfact & Detergents

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This work reviews the use of carbohydrates and their derivatives as renewable raw materials in the production of surfactants. Methods to attain state‐of‐the‐art carbohydrate‐derived surfactants are described. This includes surfactants widely used nowadays and others that have not yet transcended beyond the academic field. Given the abundance of hydroxyl groups in carbohydrates and the considerable quantity of different surfactant structures that can be generated during their synthesis, selectively obtaining a target product represents a challenge. Therefore, this work focuses on the platform chemicals available to synthesize biobased surfactants. The first part of the review comprises a brief introduction of simple and complex carbohydrates to better understand their chemistry. Then, a description of the processes to obtain biobased building blocks derived from carbohydrates according to the National Renewable Energy Laboratory (NREL, USA), and their usefulness in synthesizing surfactants is presented. This provides an organized inventory of the knowledge around the synthesis–production of surfactants from carbohydrate derivatives, emphasizing raw materials that could be inserted into the circular bioeconomy concept. Finally, the current industry trends and the potential role of biobased surfactants around new dioxane regulations are discussed.

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“…Introducing bacteria with the ability to break down hydrocarbons with high oxygenase activity, like Acinetobacter, is a systematic technique to promote the breakdown of crude oil in contaminated environments. Additionally, several complexes made from biosurfactants are separated using the solvent methyl tertiary-butyl ether [151].…”

Section: Bioremediationmentioning

confidence: 99%

A review on the physicochemical and biological applications of biosurfactants in biotechnology and pharmaceuticals

Abbot

Paliwal

Sharma

et al. 2022

Heliyon

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New Trends in the Biomanufacturing of Green Surfactants: Biobased Surfactants and Biosurfactants

Cited by 24 publications

References 151 publications

Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments

Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments

Surfactants produced from carbohydrate derivatives: A review of the biobased building blocks used in their synthesis

A review on the physicochemical and biological applications of biosurfactants in biotechnology and pharmaceuticals

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