New trends in hair analysis and scientific demands on validation and technical notes

Mußhoff, Frank; Madea, Burkhard

doi:10.1016/j.forsciint.2006.05.024

Cited by 116 publications

(54 citation statements)

References 150 publications

(141 reference statements)

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“…In addition to inter-individual differences in metabolic capacity, dosage, hair growth rate, drug incorporation rates, pigmentation, and the physical state of the hair [12][13][14][15], our results suggest that amount of perspiration is also an important factor in segmental hair analysis in DFC.…”

Section: Discussionmentioning

confidence: 96%

“…Leong et al [17] found that the concentration of ketamine detected in hair from suspected ketamine abusers ranged from 0.6 to 489.0 ng/mg (mean=49.0 ng/mg), whereas the concentration of norketamine ranged from 0.8 [16], the concentration of ketamine detected in hair samples obtained from 15 ketamine abusers was in the range of 0.8 to 92.3 ng/mg (mean=20.5 ng/mg). The mechanisms of drug incorporation into hair have not been established [12]. Three processes for incorporation have been proposed [13].…”

Section: Discussionmentioning

confidence: 99%

“…However, there are still many sources of inter-individual variation in hair analysis, such as metabolic capacity, dosage, hair growth rate, drug incorporation rates, pigmentation, physical state of the hair, age, gender and body weight [12][13][14][15]. In addition, understanding the time course of drug deposition in hair shafts after a single-dose administration is essential when collecting hair specimens and interpreting results.…”

Section: Introductionmentioning

confidence: 99%

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Disposition of ketamine and norketamine in hair after a single dose

et al. 2010

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As a rapid-acting dissociative anesthetic, ketamine has been used in drug-facilitated crimes. The aim of this study is to investigate the disposition of ketamine and its main metabolite norketamine in hair after a single dose of ketamine. Four healthy volunteers were recruited into the study. Hair was collected 1, 2, 3, 4, 8, 12 and 16 weeks after a single oral dose of ketamine solution (10 mg) and analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry. The wet cotton swab wiped the scalp of the subjects at 1 h, 24 h, 48 h and 1 week after administration. Maximum hair concentrations (C (max)) for ketamine and norketamine were 19.0 ± 6.5 and 18.7 ± 13.3 pg/mg, respectively. Except for the first week, the ratio of ketamine to norketamine in most of segments (87.5%) was greater than 1. All the cotton swab samples collected at 24 and 48 h were positive. The results from cotton swabs and the concentrations of ketamine and norketamine in hair segments collected at different times showed that some of ketamine and norketamine incorporated into hair originated from sweat and sebum on the scalp of the subjects.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Disposition of ketamine and norketamine in hair after a single dose

et al. 2010

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“…Gamma-hydroxybutyrate (GHB) için; "gas chromatography/mass spectrometry (GC/MS)" tekniği uygulanır [65][66][67]. GHB ve Morfin analizi için 20 cm uzunluğunda 2-3 cm çapında saç örneklemi yapılmalıdır [9,68]. Ketamin ve metabolitleri için; "Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS)" metodu kullanılır.…”

Section: Cinsel Saldırıları Kolaylaştırabilen İlaçların Kullanım Yüzdunclassified

Drug Facilitated Sexual Assault and That the Problems in Turkey

M¹

2012

Ann Clin Anal Med

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“…For drugs of abuse, hair analysis complements blood and urine analyses by providing long-term information on an individual's drug use and is routinely applied in clinical and forensic toxicology [1][2][3][4][5]. Several groups have analysed opiates and cocaine in hair to prove illicit consumption of heroin and cocaine using immunoassay methodologies [6][7][8][9][10] and especially using gas chromatographic-mass spectrometric (GC/MS) procedures [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Cocaine and opiate concentrations in hair from subjects in a heroin maintenance program in comparison to a methadone substituted group

et al. 2008

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One month before (T-1) and 12 months after (T12) controlled i.v. administration of pharmaceutical heroin-HCl (10-100 mg/day) in the context of a heroin maintenance program (HMP), concentrations of opiates and cocaine as well as its metabolites were determined in head hair (n = 46) using a validated gas chromatographic-mass spectrometric method. In addition, a patient collective of a methadone maintenance program (MMP, daily doses 15-260 mg) was examined (n = 35). The incidence of additional cocaine consumption decreased in both groups during the study period (T-1 to T12): in HMP from 64.6% to 45.8% and in MMP from 71.4% to 60.0%. A significant reduction of cocaine consumption was defined as an at least 30% reduction of analyte concentrations in hair (Deltac > 30%). Accordingly, in HMP, a decrease in 45.8% of initially (T-1) cocaine-positive patients was determined; in MMP, the reduction was 48.6%. In 22.9% of HMP and 37.1% of MMP, an increase of cocaine concentrations was detected. Codeine and acetylcodeine were found in 50.0% and 43.5% (T-1) and 13.0% and 10.9% (T12) of the samples of the HMP, as well as in 45.7% and 25.7% (T-1) and 17.1% and 5.7% (T12) in MMP, respectively. The missing of acetylcodeine, in particular at T-1, questions its applicability as a characteristic marker of a preceding consumption of illicit heroin in hair analysis.

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New trends in hair analysis and scientific demands on validation and technical notes

Cited by 116 publications

References 150 publications

Disposition of ketamine and norketamine in hair after a single dose

Disposition of ketamine and norketamine in hair after a single dose

Drug Facilitated Sexual Assault and That the Problems in Turkey

Cocaine and opiate concentrations in hair from subjects in a heroin maintenance program in comparison to a methadone substituted group

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