New Treatment Options Using 5-HT3 Receptor Antagonists in Rheumatic Diseases

Abstract

In vitro studies have shown that a blockade of 5-HT3 receptors brings about a reduction of tumor necrosis factor, IL-1 beta, IL-2, IL-6 as well as a decrease in prostaglandins. Clinical trials have provided evidence of pain reduction in a subgroup of fibromyalgia syndrome and, moreover, have demonstrated that tropisetron injected locally for insertion tendinoses and myofascial syndromes with associated trigger points leads to an alleviation of pain that is comparable to injections with the combination of corticosteroids and local anesthetics. The effects achieved by intra-articular injections in cases of osteoarthritis and rheumatoid arthritis paralleled those exerted by intraarticular injection of corticosteroids. In addition, the positive effects produced by systemically administered tropisetron on scleroderma need to be considered since they suggest that this therapeutic principle can also be applied systemically in immunologic processes.

Ginger and its Effects on Inflammatory Diseases

“…48,49 Laboratory studies have also shown the inhibition of serotonin receptors which is associated with the reduction of TNFα, IL1β, IL6, IL2, and prostaglandins. 37 In addition Ginger have thermogenic properties and increases energy expenditure by enhancing the thermic effect of food.…”

“…One Study shows Ginger is more effective than indomethacin in reducing the pain associated with inflammation and oxidative stress. 37 Moreover, Ginger can decrease muscle pain caused by sever exercise.…”

The effects of 5HT3 receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation

“…After development of other indications for 5HT 3 receptor antagonists, recently, immunomodulatory and anti-inflammatory properties have been observed for these antagonists [13,14]. It was found that tropisetron inhibits TNFα and IL-1β release in monocytes, PGE 2 release from synovial cells and also diminishes calcineurin-induced T-cell activation [31][32][33] and modulates Th1 cytokines [34].…”

Myofascial pain syndromes in the maxillofacial area: a common but underdiagnosed cause of head and neck pain

“…The efficacy of this drug has also been attributed to its antiphlogistic effect, which may be related to the inhibited release of substance P and other neuropeptides from nociceptors, and the blocked release of phlogistic substances from macrophages, monocytes, etc 22,69,70,91 .…”