New transdermal bioadhesive film containing oxybutynin: In vitro permeation across rabbit ear skin

Nicoli, Sara; Penna, Eduarda Alves; Padula, Cristina; Colombo, Paolo; Santi, Patrizia

doi:10.1016/j.ijpharm.2006.06.010

Cited by 31 publications

(26 citation statements)

References 21 publications

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“…It is water vapor permeable so the risk of skin irritation is reduced. Successful delivery of different drugs was obtained while testing such patches in ex vivo and in vivo experiments (7)(8)(9)(10)(11). However, a comprehensive investigation of the physical and adhesive properties of such films has not yet performed.…”

Section: Introductionmentioning

confidence: 99%

Physical Characterization of a New Skin Bioadhesive Film

2008

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Abstract. Physical properties (roughness, gloss, mechanical, surface topography and adhesive) of a bioadhesive film for the transdermal delivery of drugs and its interactions with a skin model surface were studied. Roughness is a measurement of the small-scale variations in the height of a physical surface. No significant differences in Ra between the "x" and "y" dimensions for both the skin model and patch were detected, due to uniformity in their production. Scanning electron microscope pictures showed small particles projected from the film. Those particles resulted in increasing roughness and surface area. For the patch, gloss values measured at 20°were 6.0±0.9 and at 60°, 32.2±2.2 gloss units, respectively, indicating a semi-gloss material. Concerning the mechanical properties, the tensile strength of the film resulted four-to sevenfold greater than the peel force from the model skin used, indicating the suitability of the film for skin application. The adhesion to skin model depended on the amount of water used for film application and on the elapsed time between film application and removal. Finally, the model skin that was invented by Charkoudian can be used as an alternative to costly and highly variable human skin substrates since it possesses human topography.

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Section: Introductionmentioning

confidence: 99%

Physical Characterization of a New Skin Bioadhesive Film

2008

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“…In other words, the inclusion of Azone ® in a matrix system produced an increment in the partitioning into the stratum corneum. In the case of the systems that were prepared without the enhancer, the small partitioning values may be explained if we bear in mind that the matrix itself is quite hydrophilic, and that the drug does not tend to migrate into the stratum corneum (Nicoli et al, 2006). In the case of the diffusion parameter D/H 2 , its value varied for each formulation.…”

Section: Resultsmentioning

confidence: 99%

“…Six polymeric matrix systems containing the same concentration of sumatriptan succinate were formulated via a lamination method (Nicoli et al, 2006;Padula et al, 2009). First, Plastoid ® 35 H was obtained according to the Degussa protocol: Eudragit ® E100, lauric acid, and adipic acid are added to hot water (temperature range, 78-82°C).…”

Section: Preparation Of Sumatriptan Transdermal Systemsmentioning

confidence: 99%

Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of sumatriptan succinate

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“…cellulose derivatives) are used as polymer (Amnuaikit et al, 2005;Güngör et al, 2008;Lin et al, 1991;Nicoli et al, 2006;Schroeder et al, 2007,a (Williams 2003). e. Adhesive: Adhesive should enable the transdermal system to easily adhere to the skin and should not be irritant/allergen for skin.…”

Section: Composition Of Transdermal Drug Delivery Systemsmentioning

confidence: 99%