Physical Characterization of a New Skin Bioadhesive Film

Abstract

Abstract. Physical properties (roughness, gloss, mechanical, surface topography and adhesive) of a bioadhesive film for the transdermal delivery of drugs and its interactions with a skin model surface were studied. Roughness is a measurement of the small-scale variations in the height of a physical surface. No significant differences in Ra between the "x" and "y" dimensions for both the skin model and patch were detected, due to uniformity in their production. Scanning electron microscope pictures showed small particles projected from the film. Those particles resulted in increasing roughness and surface area. For the patch, gloss values measured at 20°were 6.0±0.9 and at 60°, 32.2±2.2 gloss units, respectively, indicating a semi-gloss material. Concerning the mechanical properties, the tensile strength of the film resulted four-to sevenfold greater than the peel force from the model skin used, indicating the suitability of the film for skin application. The adhesion to skin model depended on the amount of water used for film application and on the elapsed time between film application and removal. Finally, the model skin that was invented by Charkoudian can be used as an alternative to costly and highly variable human skin substrates since it possesses human topography.

Silicone-based adhesives for long-term skin application: cleaning protocols and their effect on peel strength

“…Considering these difficulties, pig skin has been suggested to be a suitable model to replace human skin during peel test. The anatomy, topical features such as texture and roughness (R a values, the arithmetical mean value of the amounts of the ordinate value within an individual measuring distance, for both human and pig skin are 20±3 μm [24]), and the biochemical property of pig skin are remarkably similar to those of human skin [21]. Therefore, hair-removed pig skins have become increasingly utilized as a substrate material to mimic human skin for topical adhesion studies [25,26].…”

Bioadhesive Films Containing Benzocaine: Correlation Between In Vitro Permeation and In Vivo Local Anesthetic Effect

“…The film is water-based, mechanically stable, vapor permeable, and not adhesive in the dry state but only when applied on wet skin, thus reducing the possibilities of skin irritation. This new platform, named Patch-non-Patch ® , is a film presenting the adhesive and drug reservoir functions in a monolayer structure (12,13). Recently published studies have reported the applications of the Patch-non-Patch ® technology to a variety of actives, such as lidocaine (12,14), caffeine (15), oxybutinyn (16), sumatriptan (17), nicotine and bupropion (18).…”

Dynamics of Water and Small Molecules in Bioadhesive Polymer Films

“…The macroscopic physical properties of the patches are described in ref. [7]. Films loaded with lidocaine were prepared following the same procedure and adding a lidocaine HCl solution in water/sorbitol to the pure film forming agent.…”