New Ti-based Ti–Cu–Zr–Fe–Sn–Si–Ag bulk metallic glass for biomedical applications

Pang, Shujie; Liu, Ying; Li, Haifei; Sun, Lulu; Li, Yan; Zhang, Tao

doi:10.1016/j.jallcom.2014.07.021

Cited by 81 publications

(41 citation statements)

References 32 publications

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“…After multi-substitution, the mixing entropy of the alloys is significantly enhanced, and the crystallization process exhibits a higher level of complexity, implying a better GFA. It is worth mentioning that the critical diameter for glass formation was reported to be 7 mm for Ti 47 Cu 38 Zr 7.5 Fe 2.5 Sn 2 Si 1 Ag 2 alloy [56], which is the largest among the Be-and Pd-free Ti-based BMGs. …”

Section: Be-and Pd-free Ti-based Bmgsmentioning

confidence: 99%

“…In 1998, the first Ti-based BMG was successfully prepared by a copper mold casting in a Ti-Cu-Ni-Sn alloy system [39]. Encouraged by this success, with the effort of scholars all over the world, a number of Ti-based BMGs, such as Ti-Cu-Ni [40,41], Ti-Zr-Be [42,43], Ti-Zr-Cu-Ni-Sn [44,45], Ti-Zr-Cu-Pd-(Sn, Si, Nb) [46][47][48][49][50], Ti-Zr-Cu-Ni-Be [51][52][53], Ti-Zr-Hf-Cu-Ni-Si-Sn [54], and Ti-Cu-Zr-Fe-Sn-Si-(Ag, Sc) [55][56][57], have been developed over the last few decades. Figure 1 shows the maximum diameters for glass formation obtained in different alloy systems and the year in which they were discovered [8,[58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73].…”

Section: Glass-forming Ability Of Ti-based Bmgsmentioning

confidence: 99%

“…Recently, a novel strategy for designing BMG with high mixing entropy and large GFA has been proposed. Using this method, a series of Ti-Cu-Zr-Fe(Co)-Sn-Si-Ag(Sc) [56,57] BMGs has been discovered by multi-substitution of similar elements. After multi-substitution, the mixing entropy of the alloys is significantly enhanced, and the crystallization process exhibits a higher level of complexity, implying a better GFA.…”

Section: Be-and Pd-free Ti-based Bmgsmentioning

confidence: 99%

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Review on the Research and Development of Ti-Based Bulk Metallic Glasses

Gong

Deng

Jin

et al. 2016

Metals

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Abstract:Ti-based bulk metallic glasses (BMGs) are very attractive for applications because of their excellent properties such as high specific strength and high corrosion resistance. In this paper, we briefly review the current status of the research and development of Ti-based bulk metallic glasses. Emphasis is laid on glass-forming ability, mechanical properties, corrosion resistance, and biocompatibility.

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Section: Be-and Pd-free Ti-based Bmgsmentioning

confidence: 99%

Section: Glass-forming Ability Of Ti-based Bmgsmentioning

confidence: 99%

Section: Be-and Pd-free Ti-based Bmgsmentioning

confidence: 99%

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Review on the Research and Development of Ti-Based Bulk Metallic Glasses

Gong

Deng

Jin

et al. 2016

Metals

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“…[ 69 ] Further exploration of the composition space revealed Ca-rich alloys with signifi cantly increased casting diameters, and improved thermoplastic processing properties, excellent cell proliferation, and increased bone hyperplasia. [ 72,75,76 ] While the Young's modulus of the ternary systems is almost identical to that of dense cortical bone (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), the strengths are not as impressive as the Mg-rich systems, exhibiting failure in compression at around 400 MPa. Despite very limited H 2 evolution, the corrosion of the ternary alloys is very rapid, with some of the Ca-rich alloy pins dissolving completely within just 3 h. [ 75 ] Recently however, it has been demonstrated that additional alloying elements such a Yb and Sr can signifi cantly reduce the corrosion rate of the Ca-rich systems (Figure 4 ), bringing it signifi cantly below crystalline Mg-alloys, and suggesting a viable alternative to the smallerdiameter Mg-rich systems.…”

Section: Glassy Magnesium Alloysmentioning

confidence: 97%

“…The material exhibited strength of 2 GPa, signifi cant compressive bulk plasticity, similar corrosion resistance to that of Ti-6Al-4V in PBS, and similar cell viabilities with MC3T3-E1 pre-osteoblast cells. [ 23 ] …”

Section: Ti Systemsmentioning

confidence: 99%

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

et al. 2016

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Their inherent lack of dislocations and hence slip planes leads to exceptionally high strength and elasticity, approaching the theoretical limit. While oxide glasses and ceramics exhibit low toughness and brittle failure, BMGs can display toughness comparable to crystalline metals. [ 2 ] The lack of grain structure means that BMGs are homogeneous and exhibit isotropic behavior, even at sub-micrometer length scales, and, without grain boundaries or precipitates as oxidation sites, corrosion rates are significantly reduced compared to conventional metals.BMGs soften above an alloy-specifi c glass-transition temperature ( T g ) before eventual, time-dependent, crystallization at a higher, crystallization temperature ( T x ). In this supercooled liquid region (SCLR) between T g and T x , the viscous BMGs may be plastically shaped under low applied forces using polymer-processing techniques, such as hot embossing, extrusion, foaming, and injection and blow moulding, before again cooling to a solid metallic glass. With relatively low processing temperatures and no solidifi cation shrinkage, parts can be formed to netshape with excellent accuracy, and geometries, and surface patterns previously diffi cult in metals can be achieved with ease. [3][4][5][6][7] Such remarkable properties and behavior have led to significant interest in BMGs as engineering materials over the past 20 years, but it is only recently that their potential for use as a biomaterial has been studied. [ 8 ] To date, our understanding of material biocompatiblity has evolved mainly through empirical testing, observing the interaction of materials with cells and host tissue in vitro and in vivo. Materials can induce host responses varying from local and systemic infl ammation, hypersensistivity, toxicity, and even tumorogenesis, meaning that thorough evidence of material safety is required before regulatory approval and clinical translation. We now largely recognise the material characteristics that generate both favorable and undesired host responses, as outlined by Williams, [ 9 ] offering the opportunity for informed material design, while being cognisant that biocompatibility is specifi c to the application and host environment. [ 10 ] The original requirement of fi rst generation "biocompatible" materials was bio-inertness. [ 11 ] This included a resistance to corrosion in the body, and here Ti-and Co-based alloys scored highly. [ 12 ] Less-inert metals, such as Mg, were therefore not deemed suitable, although the ions released on dissolution are generally not harmful to the human body. However, current design requirements for biomaterials, including most recently biometals, include eliciting an appropriate host response, [ 13 ] and this can include the need to biodegrade and resorb. There are potential advantages for BMGs that span applications of With increasing knowledge of the materials science of bulk metallic glasses (BMGs) and improvements in their properties and processing, they have started to become candidate materials for biomedical dev...

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Combinatorial Development and In Vitro Characterization of the Quaternary Zr–Ti–X–Y (X–Y = Cu–Ag/Co–Ni) Metallic Glass for Prospective Bioimplants

et al. 2019

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The prospect of Zr‐based metallic glasses (MGs) in achieving a combination of properties, such as excellent electrochemical properties and extended biocompatibility, has been studied in this work. The combinatorial method (magnetron co‐sputtering) has been adopted to fabricate two novel quaternary MG systems (Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11) with optimized compositions. The structural analysis has been performed by the grazing incidence x‐ray diffraction and high‐resolution transmission electron microscopy to affirm the disordered structure of the MG systems. The electrochemical analysis demonstrates lower corrosion‐ (0.10 and 0.04 μA cm−2), and passive (2.93 and 1.88 μA cm−2) current densities of the MGs. In addition, the MGs are found to have higher charge transfer resistance (4.70 and 7.86 MΩ cm2) compared to the 316L stainless steel (SS) (0.15 MΩ cm2) and cp‐Ti (0.53 MΩ cm2). The electrochemical features are indicative towards higher corrosion‐resistance capabilities of Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs to prevent adverse biological reactions. Additionally, the cell proliferation analysis manifests higher cell proliferation on the Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs for the MC3T3‐E1 preosteoblast cells. Besides, the MTS assay analysis strengthens the prediction of cytocompatibility of the MGs. The integration of such unique properties makes these MG systems ideal candidates for biomedical implants.

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New Ti-based Ti–Cu–Zr–Fe–Sn–Si–Ag bulk metallic glass for biomedical applications

Cited by 81 publications

References 32 publications

Review on the Research and Development of Ti-Based Bulk Metallic Glasses

Review on the Research and Development of Ti-Based Bulk Metallic Glasses

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

Combinatorial Development and In Vitro Characterization of the Quaternary Zr–Ti–X–Y (X–Y = Cu–Ag/Co–Ni) Metallic Glass for Prospective Bioimplants

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