Combinatorial Development and In Vitro Characterization of the Quaternary Zr–Ti–X–Y (X–Y = Cu–Ag/Co–Ni) Metallic Glass for Prospective Bioimplants

Abstract

The prospect of Zr‐based metallic glasses (MGs) in achieving a combination of properties, such as excellent electrochemical properties and extended biocompatibility, has been studied in this work. The combinatorial method (magnetron co‐sputtering) has been adopted to fabricate two novel quaternary MG systems (Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11) with optimized compositions. The structural analysis has been performed by the grazing incidence x‐ray diffraction and high‐resolution transmission electron microscopy to affirm the disordered structure of the MG systems. The electrochemical analysis demonstrates lower corrosion‐ (0.10 and 0.04 μA cm−2), and passive (2.93 and 1.88 μA cm−2) current densities of the MGs. In addition, the MGs are found to have higher charge transfer resistance (4.70 and 7.86 MΩ cm2) compared to the 316L stainless steel (SS) (0.15 MΩ cm2) and cp‐Ti (0.53 MΩ cm2). The electrochemical features are indicative towards higher corrosion‐resistance capabilities of Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs to prevent adverse biological reactions. Additionally, the cell proliferation analysis manifests higher cell proliferation on the Zr50Ti32Cu13Ag5 and Zr40Ti37Co12Ni11 MGs for the MC3T3‐E1 preosteoblast cells. Besides, the MTS assay analysis strengthens the prediction of cytocompatibility of the MGs. The integration of such unique properties makes these MG systems ideal candidates for biomedical implants.

Deposition and Optical Characterization of Sputter Deposited p-Type Delafossite CuGaO2 Thin Films Using Cu2O and Ga2O3 Targets

“…In this family of p-type TCOs, CuCrO 2 is known to have antibacterial properties. Further, these antibacterial properties may find applications in biomedical implants, as reported by Jabed et al in metallic glass-based materials [7]. TCOs are achieved by doping metal oxides by adding more charge carriers while essentially maintaining their optical characteristics.…”

Distinctive Features and Fabrication Routes of Metallic-Glass Systems Designed for Different Engineering Applications: A Review

“…Metallic-glass systems were also found to have a higher resistance towards localized or pitting corrosion compared to crystalline materials [220,272]. One of the primary reasons behind pitting corrosion is the presence of physical irregularities in the protective oxide or passive layer [266,273]. Different phases, scratches, grain boundaries, and crystal imperfections can cause damage in the passive layer and eventually trigger catastrophic failure of the systems [274].…”

Enhanced Corrosion Resistance of TiZrN-Coated Additively Manufactured 8620 Low-Alloy Steel in Nitrate Salt Solution and Salt Bath

“…Zirconium is readily oxidized, which makes it resistant to chemical attacks [85][86][87]. Furthermore, the capacity of titanium to build corrosion-resistant oxide is well recognized [88,89]. Thus, the presence of such outstanding oxide formers (i.e., Zr and Ti) on the film provided enhanced corrosion resistance to the 8620 substrates.…”