New thermo-responsive polymer materials based on poly(2-ethyl-2-oxazoline) segments

Christova, Darinka; Velichkova, R.; Loos, Wouter; Goethals, Eric J.; Prez, Filip Du

doi:10.1016/s0032-3861(03)00139-3

Cited by 173 publications

(162 citation statements)

References 24 publications

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“…The cloud points were found to depend on polymer concentration revealing a lower critical solution temperature (LCST) in the range of 61-64 °C depending on the polymer molecular weight (20-500 kDa). PEtOx with a molecular weight below 10 kDa does not exhibit a cloud point at 0.5 wt% as first demonstrated by Du Prez [17]. Furthermore, PEtOx can be salted out from aqueous solution by the addition of sodium chloride, leading to a decrease of the LCST, whereas the opposite effect is observed with tetrabutylammonium bromide [16].…”

Section: Thermoresponsive Poly(2-oxazoline)s In Aqueous Solutionmentioning

confidence: 68%

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Bioinspired Poly(2-oxazoline)s

2011

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Poly(2-oxazoline)s are regarded as pseudopeptides, thus bioinspired polymers, due to their structural relationship to polypeptides. Materials and solution properties can be tuned by varying the side-chain (hydrophilic-hydrophobic, chiral, bioorganic, etc.), opening the way to advanced stimulus-responsive materials and complex colloidal structures. The bioinspired -smart‖ solution and aggregation behavior of poly(2-oxazoline)s in aqueous environments are discussed in this review.

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Section: Thermoresponsive Poly(2-oxazoline)s In Aqueous Solutionmentioning

confidence: 68%

“…Du Prez et al introduced non-degradable covalently cross-linked hydrogels consisting of PEtOx macromonomers and hydroxyethyl methacrylate (HEMA) or hydroxypropylacrylate [17]. These hydrogels exhibited reversible swelling-deswelling behavior upon step-wise change of temperature from 20 to 70 °C.…”

Section: Thermoresponsive Poly(2-oxazoline)-based Hydrogelsmentioning

confidence: 99%

Bioinspired Poly(2-oxazoline)s

2011

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“…These variation possibilities make the class of poly(2-oxazoline)s very well suited for the synthesis of well-defined systematic libraries of (co)polymers and, thus, for the determination of structure-property relationships. Other recent studies on structure-property relationships in poly(2-oxazoline)s include their use as compatibilizer, [19] their lower critical solution temperature (LCST), [20,21] micellization behavior, [22] as well as antimicrobial properties. [23,24] However, the generally long polymerization times for 2-oxazolines that range from days to weeks [25,26] represent a major disadvantage that obstructs fast synthesis and screening of libraries of poly(2-oxazoline)s. Therefore, the use of microwave irradiation has been investigated as an alternative heat source for the polymerization of 2-oxazolines.…”

Section: Talents and Trendsmentioning

confidence: 99%

Poly(2‐oxazoline)s: Alive and Kicking

Hoogenboom

2007

Macro Chemistry & Physics

109

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The development of various living/controlled polymerization techniques has allowed the synthesis of a large variety of well‐defined (co)polymers with varied polymer length, composition, and architecture, for example. Screening this large possible parameter space for a polymer with certain properties can be a very demanding process. Therefore, we aim to rapidly synthesize and systematically screen libraries of copolymers to determine structure‐property relationships that might allow the future design of novel (co)polymers with predictable properties. The cationic ring‐opening polymerization of 2‐oxazolines has been adapted for the synthesis of libraries of well‐defined (co)polymers. In this contribution, the optimization of the polymerization procedure using both high‐throughput experimentation and microwave irradiation is discussed. Subsequently, the microwave‐assisted synthesis of well‐defined libraries of (co)poly(2‐oxazoline)s and the determination of structure‐property relationships for these polymers is described. Moreover, the polymerization of a soy‐based 2‐oxazoline monomer will be illustrated as a ‘green’ approach to replace current oil‐based feedstock by renewable resources.magnified image

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“…We chose poly(ethylene oxide) as the core, due to its wide solubility in common solvents, its commercial availability and chemical inertness, enabling various chemical modifications. As the outer block (shell), we used poly(2-ethyl-2-oxazoline), a well-studied material with proven biocompatibility [22] and temperature-responsive properties (lower critical solution properties, LCST) above a threshold-molar mass in aqueous media [46,47].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Solution Properties of Double Hydrophilic Poly(ethylene oxide)-block-poly(2-ethyl-2-oxazoline) (PEO-b-PEtOx) Star Block Copolymers

et al. 2013

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Abstract:We demonstrate the synthesis of star-shaped poly(ethylene oxide)-block-poly(2-ethyl-2-oxazoline) [PEO m -b-PEtOx n ] x block copolymers with eight arms using two different approaches, either the "arm-first" or the "core-first" strategy. Different lengths of the outer PEtOx blocks ranging from 16 to 75 repeating units were used, and the obtained materials [PEO 28 -b-PEtOx x ] 8 were characterized via size exclusion chromatography (SEC), nuclear magnetic resonance spectroscopy (NMR), and Fourier-transform infrared spectroscopy (FT-IR) measurements. First investigations regarding the solution behavior in water as a non-selective solvent revealed significant differences. Whereas materials synthesized via the "core-first" method seemed to be well soluble (unimers), aggregation occurred in the case of materials synthesized by the "arm-first" method using copper-catalyzed azide-alkyne click chemistry.

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New thermo-responsive polymer materials based on poly(2-ethyl-2-oxazoline) segments

Cited by 173 publications

References 24 publications

Bioinspired Poly(2-oxazoline)s

Bioinspired Poly(2-oxazoline)s

Poly(2‐oxazoline)s: Alive and Kicking

Synthesis and Solution Properties of Double Hydrophilic Poly(ethylene oxide)-block-poly(2-ethyl-2-oxazoline) (PEO-b-PEtOx) Star Block Copolymers

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