2023
DOI: 10.1016/j.biopha.2023.114657
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New therapy for pancreatic cancer based on extracellular vesicles

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Cited by 4 publications
(2 citation statements)
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“…S. Araujo-Abad et al utilized small EVs derived from the RWP-1 cell line and loaded them with two chemotherapeutic drugs, temozolomide or EPZ015666, aiming to enhance the effectiveness of chemotherapy for treating PDAC, the most common aggressive form of PC. They observed a greater antiproliferative effect of temozolomide-loaded EVs compared to EPZ015666-loaded EVs when used in a PC cell line [ 149 ]. In a comparative investigation of various methods for loading EVs with chemotherapeutic agents, namely electroporation, sonication, and incubation with paclitaxel (PTX) and gemcitabine (GEM), it was demonstrated that sonication achieved superior efficiency in drug loading compared to incubation and electroporation.…”
Section: Structural Gastroenteric Disease and Ev-based Therapymentioning
confidence: 99%
See 1 more Smart Citation
“…S. Araujo-Abad et al utilized small EVs derived from the RWP-1 cell line and loaded them with two chemotherapeutic drugs, temozolomide or EPZ015666, aiming to enhance the effectiveness of chemotherapy for treating PDAC, the most common aggressive form of PC. They observed a greater antiproliferative effect of temozolomide-loaded EVs compared to EPZ015666-loaded EVs when used in a PC cell line [ 149 ]. In a comparative investigation of various methods for loading EVs with chemotherapeutic agents, namely electroporation, sonication, and incubation with paclitaxel (PTX) and gemcitabine (GEM), it was demonstrated that sonication achieved superior efficiency in drug loading compared to incubation and electroporation.…”
Section: Structural Gastroenteric Disease and Ev-based Therapymentioning
confidence: 99%
“…PDAC cell death via clathrin-mediated endocytosis [149,150] Engineered small EVs with high CD47 expression and c(RGDyC) modification to deliver short RNAi against YTHDF1: a novel therapeutic strategy for GC via epigenetic and immune regulation [155,166] colon IBD EVs released by MSCs and loaded with miR-146: a new strategy in the treatment of IBD in mouse models [126] EVs and bacteria-derived membrane vesicles (OMVs) derived from normal feces: restore the intestinal barrier in IBD subjects [38,127,128,167] Exo containing PSMA7 derived from saliva: an important protein biomarker for IBD [168] CRC Folic acid-modified exo-liposome hybrid nanoparticles loaded with ALKBH5 mRNA: a novel therapeutic strategy for CRC [156] EVs derived from CT26 and loaded with miR-34a mimics: a new strategy for CRC gene therapy in mouse model [159] EVs derived from milk: a reduction in primary tumor burden in mouse models of CRC and breast cancer [161,162] Exosomes secreted from HEK293T transfected with Her2-mCherry plasmid and loaded with both 5-FU and miR-21i: reversing the drug resistance in CRC cells [164,165] Exosomes secreted from MSCs modified with 5TR1 or with magnetic nanoparticles, folic acid, and DOXO: the inhibition of CRC growth in mouse models [151][152][153][154]…”
Section: Organ Pathology Ev-based Preparations and Applications Refer...mentioning
confidence: 99%