New therapeutic strategy for combating the increasing burden of allergic disease: Probiotics—A Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota (NAMI) Research Group report

Rautava, Samuli; Kalliomäki, Marko; Isolauri, Erika

doi:10.1016/j.jaci.2005.02.010

Cited by 115 publications

(76 citation statements)

References 61 publications

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“…Gut microbiotas can contribute to excess host adiposity (14)(15)(16), protect against the development of type 1 diabetes (17), and induce colitis (18) and metabolic syndrome (19). Thus, the microbiota has been suggested as a target for therapeutic intervention for several chronic diseases (13,(20)(21)(22). Adult microbiotas are thought to be relatively stable over time (14,23,24); this stability imparts resilience to disturbance, ensuring continued gut function.…”

Section: Discussionmentioning

confidence: 99%

Succession of microbial consortia in the developing infant gut microbiome

Koenig

Spor

Scalfone

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

2,158

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1,904

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The colonization process of the infant gut microbiome has been called chaotic, but this view could reflect insufficient documentation of the factors affecting the microbiome. We performed a 2.5-y case study of the assembly of the human infant gut microbiome, to relate life events to microbiome composition and function. Sixty fecal samples were collected from a healthy infant along with a diary of diet and health status. Analysis of >300,000 16S rRNA genes indicated that the phylogenetic diversity of the microbiome increased gradually over time and that changes in community composition conformed to a smooth temporal gradient. In contrast, major taxonomic groups showed abrupt shifts in abundance corresponding to changes in diet or health. Community assembly was nonrandom: we observed discrete steps of bacterial succession punctuated by life events. Furthermore, analysis of ≈500,000 DNA metagenomic reads from 12 fecal samples revealed that the earliest microbiome was enriched in genes facilitating lactate utilization, and that functional genes involved in plant polysaccharide metabolism were present before the introduction of solid food, priming the infant gut for an adult diet. However, ingestion of table foods caused a sustained increase in the abundance of Bacteroidetes, elevated fecal short chain fatty acid levels, enrichment of genes associated with carbohydrate utilization, vitamin biosynthesis, and xenobiotic degradation, and a more stable community composition, all of which are characteristic of the adult microbiome. This study revealed that seemingly chaotic shifts in the microbiome are associated with life events; however, additional experiments ought to be conducted to assess how different infants respond to similar life events.

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Section: Discussionmentioning

confidence: 99%

Succession of microbial consortia in the developing infant gut microbiome

Koenig

Spor

Scalfone

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

2,158

146

1,904

View full text Add to dashboard Cite

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“…Studies outlining probiotics' role in preventing or controlling Helicobacter pylori are growing (30). The role of probiotics in the immune system is also noteworthy, as symptoms of NVP have been previously suggested as being triggered by immunological changes following conception (31). Probiotics effect upon anti-and pro-inflammatory cytokines by modulating the skewness in the balance of T helper cells Th1 and Th2, thereby inducing the development of a population of T cells producing anti-inflammatory cytokines, has been previously outlined (31).…”

Section: Discussionmentioning

confidence: 99%

Dietary changes during first trimester pregnancy for women with nausea and vomiting in the Norwegian Mother and Child Cohort Study

Chortatos¹,

Haugen²,

Iversen³

et al. 2014

Nor J Epidemiol

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Objective: Examine responses given to questions addressing whether pregnancy had caused women with nausea and vomiting (NVP) or symptom-free (SF) to alter their food habits in the first trimester in order to better understand the dietary changes taking place in women with NVP. Method: Using questions featured in the Norwegian Mother and Child Cohort Study (MoBa) specifically asking participants about alterations in diet and episodes of nausea and vomiting. The final sample used included 30,072 women. Results: We found 46% with no symptoms of nausea and/or vomiting in pregnancy, whilst 54% reported both nausea and vomiting. The NVP group of women were the group most affected with changes in food consumption, having the lowest proportion reporting to eat as before pregnancy, as well as the highest proportion reporting 'eating more' and 'reduced eating'. The SF group reported eating more than NVP group in one instance, that being for chocolate (SF 17.7% vs NVP 16.3%). Conclusion:We have shown a higher degree of dietary change in women with NVP compared to SF women. We also found chocolate as the only exception, with a higher proportion of SF women eating more of this food item.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…In addition, the promising potential of using selected strains of intestinal microbes as probiotics has spawned research elucidating the effects of specific probiotic bacteria in vitro and in vivo [1]. However, data from these studies should be interpreted cautiously for a number of reasons.…”

Section: Host-commensal Cross Talkmentioning

confidence: 99%

“…Disruption of this homeostasis is known to contribute to the pathogenesis of intestinal inflammatory conditions, such as inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). Intestinal bacteria also contribute to healthy morphologic and functional maturation of the intestinal immune system in the postnatal period, and alterations in gut microbiota composition in infancy have been associated with subsequent development of immunemediated disease in epidemiologic studies [1]. The clinical implications of understanding host-microbe cross talk are significant, and a considerable amount of research has therefore focused on understanding the molecular basis of these interactions.…”

Section: Introductionmentioning

confidence: 99%

Commensal bacteria and epithelial cross talk in the developing intestine

Rautava¹,

Walker

2007

Curr Gastroenterol Rep

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Indigenous intestinal microbes have co-evolved with the intestinal immune system to form a symbiotic ecosystem. In the postnatal period, intestinal microbes provide the developing gut with stimuli that are necessary for healthy maturation of the intestinal immune system. Cross talk between the host and commensal microbes is an essential component of gut homeostasis mechanisms also in later life. During recent years, innovative research has shed light on the molecular mechanisms of these interactions.

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New therapeutic strategy for combating the increasing burden of allergic disease: Probiotics—A Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota (NAMI) Research Group report

Cited by 115 publications

References 61 publications

Succession of microbial consortia in the developing infant gut microbiome

Succession of microbial consortia in the developing infant gut microbiome

Dietary changes during first trimester pregnancy for women with nausea and vomiting in the Norwegian Mother and Child Cohort Study

Commensal bacteria and epithelial cross talk in the developing intestine

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