New Therapeutic Perspectives in Premature Ejaculation

Paço, J. Simões; Pereira, Bruno Jorge

doi:10.1016/j.urology.2015.11.003

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…Both patients and their sexual partners were considered important for the assessment of improvements in sexual intercourse satisfaction. There is a lack of systemic and standard measures for the clinical efficacy of PE treatment, which may frustrate both physicians and patients (Simões Paço & Jorge Pereira, 2016). In the current study, four primary properties were enrolled, including the improvement in intravaginal ejaculation latency time, the couple's mental status, the ability to control ejaculation, and sexual intercourse satisfaction.…”

Section: Discussionmentioning

confidence: 99%

The Use of Delphi Method and Analytical Hierarchy Process in the Establishment of Assessment Tools in Premature Ejaculation: The Scoring System for Premature Ejaculation Treatment Outcomes

et al. 2020

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There is a lack of objective tools to comprehensively evaluate premature ejaculation (PE) treatment results clinically. We aimed to describe the development of a novel scoring system for PE treatment results as an example of using the Delphi method and an analytical hierarchy process for complex decision-making in the field of sexual medicine. A Delphi question survey was adopted to collect expert opinions from 47 Chinese specialists in andrology/urology on the assessment of PE treatment outcomes based on four primary properties, that is, the improvement in intravaginal ejaculation latency time, a couple’s mental status, the ability to control ejaculation, and sexual intercourse satisfaction. Different weights on those primary properties were assigned to create a mathematical hierarchy matrix and then perform an analysis. The scores were assigned according to the calculated weights. The ratio among the combined weights of the four primary properties was 1:3:2:3. The total numerical score was 36. Scores above 27, between 26 and 18, and below 17 indicated significant improvement, moderate improvement, and no improvement in PE, respectively, with selected treatments. The scoring system with 36 points can be used by physicians, patients, and their sexual partners to comprehensively and objectively assess quantitative PE treatment results.

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Section: Discussionmentioning

confidence: 99%

The Use of Delphi Method and Analytical Hierarchy Process in the Establishment of Assessment Tools in Premature Ejaculation: The Scoring System for Premature Ejaculation Treatment Outcomes

et al. 2020

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“…In view of drawbacks of the existing therapies for PE, injection of botulinum-A toxin was suggested as a promising alternative PE treatment [10,11,26,27] . The relatively prolonged chemical denervation reported with onaBoNT-A injection may render PE men capable to spontaneously engage in sexual activity without requiring oral medications or applying topical treatment [28] . In two patent applications, Gaxiola et al [26] have proposed treating PE and prolonging ejaculation latency by injecting onaBoNT-A into the penis; or into the frenulum, prepuce, or glans penis [27] .…”

Section: Discussionmentioning

confidence: 99%

Can Intraprostatic Injection of OnabotulinumtoxinA be Benefi cial to Treat Premature Ejaculation? Results of a Prospective Study

et al. 2017

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We prospectively evaluated efficacy and adverse effects of intraprostatic injections of onabotulinumtoxinA to treat premature ejaculation. Twenty-four men ≥19 years-old with premature ejaculation for ≥ 6 months and intravaginal ejaculation latency time ≤ 2 minutes underwent transurethral intraprostatic injections of onabotulinumtoxinA (100 U). Primary endpoint was change of intravaginal ejaculation latency time at 3-months. Secondary endpoints included changes in premature ejaculation profile and patient-reported global impression of change (PGI). Mean baseline ejaculation latency time has significantly increased at 1-, 3- and 6-months, respectively. In premature ejaculation profile “perceived control over ejaculation”, significant improvement was reported at 3-months, while non-significant changes were reported at 1- and 6-months. Patients reported non-significant changes of “personal distress related to ejaculation” and “interpersonal difficulty related to ejaculation”. Only 8.3%, 12.5% and 12.5% of men reported “better” at 1-, 3- and 6-months, respectively, while all other patients reported “no change” or “slightly better” in patient-reported global impression of change. No serious adverse effects were observed. Improvements of intravaginal ejaculation latency time were not clinically meaningful, as most men reported “no change” or “slightly better” in patient-reported global impression of change. These marginal improvements did not support using onabotulinumtoxinA intraprostatic injections to remedy premature ejaculation.

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“…However, many questions about how drugs, especially herbal drugs, affect premature ejaculation remain unanswered. Meanwhile, studies indicated that the relief of mental problems and the prevention of serotonin reuptake such as the SSRIs with sedative properties can help to treat this disorder 39,[47][48][49][50] . Overall, medicinal plants are effective on sexual dysfunction via several mechanisms of action (Fig.…”

Section: Medicinal Plants Effective On Premature Ejaculationmentioning

confidence: 99%

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2017

IJPSR

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Medicinal plants used in traditional medicine and various cultures can be valuable resources for discovering new drugs. This review was conducted to report Iranian medicinal plants effective on sexual dysfunction (sexual desire disorders, erectile dysfunction, and premature ejaculation). To conduct this systematic review, the search terms Sexual*, Aphrodisiacs, Erectile, and Libido* combined with Medicinal plants, Herb*, and Phyto* were used to retrieve relevant publications from the databases International Scientific Institute, PubMed, Scopus, and EBSCO. Tribulus terrestris, Rosa damascena, Crocus sativus L., rosmarinic acid, and crocin are a number of medicinal plants and their derivatives that have libidoboosting properties. C. sativus, Zingiber officinale, and Peganum harmala are some of the plants that exert therapeutic effects on erectile dysfunction. Boswellia serrata and Lavandula angustifolia are two plants used to treat premature ejaculation. Medicinal plants that are used to treat sexual dysfunctions in Iran can help to improve sexual desire disorders, erectile dysfunction, and premature ejaculation through certain mechanisms such as affecting the cerebral neurotransmitters and sex cells, increasing physical strength, causing hormonal changes, and affecting neurons and certain parts of the brain. They can be used to discover and produce new effective drugs for sexual dysfunction.

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New Therapeutic Perspectives in Premature Ejaculation

Cited by 13 publications

References 35 publications

The Use of Delphi Method and Analytical Hierarchy Process in the Establishment of Assessment Tools in Premature Ejaculation: The Scoring System for Premature Ejaculation Treatment Outcomes

The Use of Delphi Method and Analytical Hierarchy Process in the Establishment of Assessment Tools in Premature Ejaculation: The Scoring System for Premature Ejaculation Treatment Outcomes

Can Intraprostatic Injection of OnabotulinumtoxinA be Benefi cial to Treat Premature Ejaculation? Results of a Prospective Study

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