New tetranortriterpenoids, langsatides A and B from the seeds of Lansium domesticum Corr. (Meliaceae)

Rudiyansyah, Rudiyansyah; Alimuddin, Andi Hairil; Masriani,; Muharini, Rini; Proksch, Peter

doi:10.1016/j.phytol.2017.11.019

Cited by 13 publications

(6 citation statements)

References 12 publications

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“…Lansium domesticum is a species of the Meliaceae family that can grow to 40-50 feet. The fruit is locally known as langsat, long-kong, duku, lang-sook, or langsat-khao [10]. Hua et al [11] research explains that hydrochar prepared from microbial aging can adsorb Cd(II) with an adsorption capacity of 4.19 mg/g.…”

Section: ■ Introductionmentioning

confidence: 99%

Low-Cost Yet High-Performance Hydrochar Derived from Hydrothermal Carbonization of Duku Peel (<i>Lansium domesticum</i>) for Cr(VI) Removal from Aqueous Solution

Mohadi

Juleanti²,

Normah³

et al. 2022

Indones. J. Chem.

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Carbon-based adsorbent as a hydrochar (Hc) material with Duku (Lansium domesticum) peel precursors has been successfully synthesized as evidenced by XRD, FT-IR, BET, and SEM analysis. XRD analysis showed the presence of diffraction peaks around 16° and 22° which indicated the presence of carbonaceous material. This is confirmed by FTIR analysis which shows the presence of vibration at 2931 cm−1 of cellulose. SEM data results showed that heterogeneous and has an irregular shape and surface area increased twice from Duku peel to Hc. Duku peel and Hc adsorbent materials were applied to adsorb heavy metal ions Cr(VI). Kinetic parameters of Cr(VI) using Duku peel and Hc showed that the optimum time reached was at 120 min. The adsorption kinetics model of Cr(VI) using Hc tends to follow the PFO model and Langmuir isotherm adsorption. Duku peel material used to adsorb Cr(VI) reached an adsorption capacity of 42.19 mg/g, while in Hc material there was an increase that reached 80.64 mg/g. The thermodynamic parameters of both materials show that the adsorption process is spontaneous.

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Section: ■ Introductionmentioning

confidence: 99%

Low-Cost Yet High-Performance Hydrochar Derived from Hydrothermal Carbonization of Duku Peel (<i>Lansium domesticum</i>) for Cr(VI) Removal from Aqueous Solution

Mohadi

Juleanti²,

Normah³

et al. 2022

Indones. J. Chem.

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“…Kokosanolide A-C compounds were isolated from seeds and had antifeedant activity against larvae of Epilachna vigintioctopunctata (Mayanti et al, 2011). Langsatides A and B were also isolated from the seeds, but they had insignificant activity as antibacterial and cytotoxic (Rudiyansyah et al, 2018) In our previous study, a compound was isolated from n-hexane soluble fraction (fraction B) of L.domesticum fruit peel ethyl acetate extract using vacuum liquid chromatography. Based on 13 C-NMR and 1 H-NMR data, this compound was identified as Lamesticumin A and displayed cytotoxic properties against T-47D cell line with IC50 15.68±0.30µg/mL (Fadhilah et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

A Sesquiterpene Aldehyde Isolated From Ethyl Acetate Extract of Lansium Domesticum Fruit Peel

2021

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Lansium domesticum (fam. Meliaceae) contains various compounds with various biological activities. Based on the previous research, extracts from several parts of the plant have biological activity. This study aimed to isolate a compound from the fruitpeel of L. domesticum and evaluate cytotoxic activity against T47D, WiDr and HepG2 cell lines. Powdered peels were macerated with ethyl acetate and the filtrate was evaporated to give EtOAc extract. Dried extract was triturated with n-hexane to give n-hexane soluble fraction (A) and insoluble fraction (B). The fraction B was separated using vacuum column chromatography (VLC) with mobile phase n-hexane: ethyl acetate and given 5 fractions. Fractions B3-B5 were combined and separated using VLC with n-hexane and ethyl acetate as mobile phase. This VLC separation gave 18 subractions, subfractions 6-9 with the similar TLC profile were combined. This subfraction was separated further using preparative thin layer chromatography to give compound 1. The Isolated compound (1) appeared as liquid. The chemical structure of 1 was identified acoording to spectroscopic data and comparison with literature. Cytotoxic bioassay was performed on T-47D, WiDr and Hep G2 cell lines in a series of concentrations at 50, 40, 30, 20, 10 and 5µg/mL, with Doxorubicine used as positive control. According to spectroscopic data, compound 1 was identified as 2-ethyl,3-(1’-hydroxy-2’-menthene) propenal, and demonstrate the strongest cytotoxicity against T-47D cell lines (IC50=39.18+1.54 µg/mL).

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“…The ethanol-ethyl acetate fraction (50:50%, v / v) of Duku bark has DNA damage-preventing activity on lymphoblast cells induced by H2O2 exposure at doses of 25, 50, 100, and 200 μg/mL (Klungsupya et al 2015). There were tetranortriterpenoids langsatides A and B were isolated from L. domesticum seed and showed weak cytotoxic and antibacterial activities (IC50>100µM) (Rudiyansyah et al 2018). Onoceranoid type triterpenoid from the methanolic extract of L.domesticum leaves is known to have antimutagenic effect (Matsumoto et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Fractions and isolated compounds from Lansium domesticum fruit peel exhibited cytotoxic activity against T-47D and HepG2 cell lines

2021

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Abstract. Fadhilah K, Wahyuono S, Astuti P. 2021. Fractions and isolated compounds from Lansium domesticum fruit peel exhibited cytotoxic activity against T-47D and HepG2 cell lines. Biodiversitas 22: 3743-3748. Lansium domesticum (Fam. Meliaceae), a tropical fruit (local name, Duku), has been reported to have various biological activities. At the moment we emphasize on searching compounds to have cytotoxic activity from the peel of L. domesticum. The study was initiated by extraction with EtOAc followed by fractionation that was monitored by thin-layer chromatography (TLC) and cytotoxicity against T-47D and HepG2 cells. The EtOAc extract of the sample was triturated with n-hexane to give n-hexane soluble (A) n-hexane insoluble fractions (B). The B fraction was fractionated by vacuum column chromatography using gradient solvent composition of n-hexane: acetone to give 18 fractions. According to TLC similarity pictures, fractions were combined to give 6 fractions (I-VI). Isolation was performed using preparative TLC, and the cytotoxic assay was performed using MTT method. The isolated compound was identified as a sesquiterpene having one aldehyde functional group, based on spectroscopic data.The isolated compound displayed cytotoxic activity on T-47D (IC50, 48.58 + 0.96 µg/mL) and HepG2 (IC50, 127.45 + 25.76 µg/mL).

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New tetranortriterpenoids, langsatides A and B from the seeds of Lansium domesticum Corr. (Meliaceae)

Cited by 13 publications

References 12 publications

Low-Cost Yet High-Performance Hydrochar Derived from Hydrothermal Carbonization of Duku Peel (<i>Lansium domesticum</i>) for Cr(VI) Removal from Aqueous Solution

Low-Cost Yet High-Performance Hydrochar Derived from Hydrothermal Carbonization of Duku Peel (<i>Lansium domesticum</i>) for Cr(VI) Removal from Aqueous Solution

A Sesquiterpene Aldehyde Isolated From Ethyl Acetate Extract of Lansium Domesticum Fruit Peel

Fractions and isolated compounds from Lansium domesticum fruit peel exhibited cytotoxic activity against T-47D and HepG2 cell lines

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