New Surface Modification of Titanium Implant with Phospho-amino Acid

Abe, Yasunori; Hiasa, Kyou; Takeuchi, Mitsuru; Yoshida, Yasuhiro; Suzuki, Kazuomi; Akagawa, Yasumasa

doi:10.4012/dmj.24.536

Cited by 18 publications

(13 citation statements)

References 19 publications

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“…The atomic concentrations of C 1s originating from PSer/Ti was 13.7±2.8 at% (Table 2). Therefore, P-Ser was confirmed to chemically bond to the Ti surface on the basis of the same evidence used in our previous study 18) . In the XPS wide-scan spectrum of RGD/Ti, N atoms originating from RGD were detected (Fig.…”

Section: Resultsmentioning

confidence: 82%

“…In fact, several biochemical surface modification techniques that are currently being investigated and pursued essentially rely on the idea of chemically bonding small amino acids to titanium surfaces by means of phosphorylation. Abe et al 18) verified that ophospho-L-threonine formed stable chemical bonds with titanium surfaces treated with HCl. Based on these results, they synthesized a RGDS(PO3H2)PA peptide.…”

Section: Introductionmentioning

confidence: 99%

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Degree of immobilization of synthetic RGDS(PO3H2)PA peptides on titanium surfaces

et al. 2010

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The purpose of this study was to characterize the chemical interaction between titanium surfaces and the peptide RGDS(PO3H2)PA (P-RGD) synthesized from RGD peptide (RGD) and o-phospho-L-serine (P-Ser), and to determine the degree of peptide immobilization on the titanium surface. X-ray photoelectron spectroscopy showed that the adsorption amount of RGD was significantly smaller than those of P-Ser and P-RGD (p<0.05). Furthermore, although it appeared that P-RGD bonded to the surface, ultrasonic rinsing with water caused it to dissociate, releasing RGD and leaving only S(PO3H2)PA bonded to the surface. These findings show that although it remains difficult to obtain a stable P-RGD layer, the phosphate functional group greatly improves immobilization of the molecule on titanium surfaces.

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Section: Resultsmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Degree of immobilization of synthetic RGDS(PO3H2)PA peptides on titanium surfaces

et al. 2010

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“…Against this background, many researches have focused on improving the adhesive properties between various types of metallic materials and hard tissues [1][2][3][4][5] . Some researches have also sought to prepare and produce membranes with antimicrobial functions and growth factors for guided tissue regeneration [6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Cell Adhesion and Proliferation Patterns on Mixed Self-assembled Monolayers Carrying Various Patios of Hydroxyl and Methyl Groups

et al. 2007

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Mixed self-assembled monolayers (SAMs) with hydroxyl and methyl surface groups were prepared as biomaterial surface models which were well-controlled and well-defined. The surface properties of mixed SAMs were examined by X-ray photoelectron spectroscopy and water contact angle measurement. It was found that the parameter of water contact angle more accurately reflected the surface compositions of mixed SAMs than by the mixing ratio of the two alkanethiols. Cell adhesion and growth were also examined on mixed SAMs of various wettability conditions. It was found that amount of serum protein adsorption changed with the surface composition. To examine the effect of surface composition on cell growth pattern, four cell types -C3H10T1/2-clone 8, L929, UVB6-2.1A, and MC3T3E1 -were incubated on mixed SAMs for three or six days. Differences in cell growth pattern against wettability were clearly recognized for each cell type. In light of the results obtained in this study, the relationship between the biocompatibility of biomaterials and surface factors were thus clarified.

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“…Indeed, passive fit of implant prostheses is the key to long-term treatment success [1][2][3] -because superstructure, abutment, osseointegrated implant, and surrounding bone act as a unit [4][5][6][7][8] . To the end of attaining a passive fit for the superstructure, it is very important that the position and orientation of implant be accurately transferred to the definitive cast [9][10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Tensile Bond Strength between Custom Tray and Elastomeric Impression Material

Maruo¹,

Oka²,

Minagi³

et al. 2007

Dent. Mater. J.

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The aim of this study was to investigate how to achieve sufficient and stable adhesive strength between impression material and tray. Impression materials were molded between autopolymerizing resin columns, and tensile strength was measured as a function of these factors: tray storage time (1, 2, 4, 7, and 10 days), adhesive drying time (0, 1, 5, 10, and 15 minutes), and tray surface roughness (air abrasion, bur-produced roughness, and no treatment). Tensile bond strength was not affected by tray storage time throughout the entire evaluation period of 10 days. As for tray adhesive drying time, Reprosil and Exaimplant yielded extremely low values for drying times of 10 minutes or less (P<0.05), while Imprint II and Impregum were not influenced by drying time. Vinyl polysiloxane achieved the highest adhesive strength with bur-produced roughness, which was significantly higher than with air abrasion or no treatment (P<0.05), whereas polyether achieved the lowest value with bur-produced roughness (P<0.05). It was concluded that surface treatment of custom tray should be adapted to the type of impression material used to achieve optimum bond strength.

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New Surface Modification of Titanium Implant with Phospho-amino Acid

Cited by 18 publications

References 19 publications

Degree of immobilization of synthetic RGDS(PO3H2)PA peptides on titanium surfaces

Degree of immobilization of synthetic RGDS(PO3H2)PA peptides on titanium surfaces

Cell Adhesion and Proliferation Patterns on Mixed Self-assembled Monolayers Carrying Various Patios of Hydroxyl and Methyl Groups

Tensile Bond Strength between Custom Tray and Elastomeric Impression Material

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