New strategy for reversing biofilm-associated antibiotic resistance through ferrocene-substituted carborane ruthenium(II)-arene complex

Synthesis, Structural Characterization and Antimicrobial Evaluation of Ruthenium Complexes with Heteroaromatic Carboxylic Acids

“…Biologically active metal complexes have gained special significance due to the need for the prevention of resistance of bacterial strains. Recently, several Cu(II), Ga(III), Zn(II), Mn(II), Ag(I), Au(III) and Ru(II) complexes with bioactive ligands have been tested as potential antibiofilm and antimicrobial agents . Among above mentioned metal complexes, ruthenium compounds are promising for medicinal and biotechnological applications as they present unique properties: (i) multiple oxidation states (II, III and IV), which are accessible in physiological conditions; (ii) favorable ligand‐exchange kinetics; (iii) multiple cytotoxic routes involving the competing processes of extracellular protein binding (active transport), due to the ability to mimic iron and cellular uptake (passive diffusion); (iv) different molecular pathways involving the concurrent intercalation and covalent binding with DNA and binding to extracellular sites inducing conformational modifications; (v) numerous synthetic opportunities for modifying the biological activity which depends on both the oxidation state of the metal center and the associated ligands surrounding it.…”

“…Among above mentioned metal complexes, ruthenium compounds are promising for medicinal and biotechnological applications as they present unique properties: (i) multiple oxidation states (II, III and IV), which are accessible in physiological conditions; (ii) favorable ligand‐exchange kinetics; (iii) multiple cytotoxic routes involving the competing processes of extracellular protein binding (active transport), due to the ability to mimic iron and cellular uptake (passive diffusion); (iv) different molecular pathways involving the concurrent intercalation and covalent binding with DNA and binding to extracellular sites inducing conformational modifications; (v) numerous synthetic opportunities for modifying the biological activity which depends on both the oxidation state of the metal center and the associated ligands surrounding it. Taking into consideration that ruthenium‐based molecules are studied as promising compounds from biological perspectives as well as the ferrocene‐substituted carborane ruthenium(II)‐arene complex exhibits promising antibiofilm activity, we have decided to investigate the ruthenium compounds in different oxidation states as potential antibiofilm agents.…”

Ruthenium-centred btp glycoclusters as inhibitors for Pseudomonas aeruginosa biofilm formation

“…To the best of our knowledge, only a few ruthenium complexes have reported signicant inhibition of biolm formation by P. aeruginosa, [52][53][54][55] with these usually being bimetallic complexes. However in general Ru(II)-polypyridyl complexes have shown lower activity towards Gram-negative species (particularly P. aeruginosa) when compared to Gram-positive bacteria (such as MRSA).…”

Biomedical applications of nano-titania in theranostics and photodynamic therapy

“…88 Photosensitive nanocomposites like TiO 2 nanoparticles could be administered systemically to the living tissue and upon attaining a certain concentration in the desired location, visible light or NIR light is passed through the subject tissue. gold, 107,108 silver, 109 zinc, 110,111 carbon fibers and complexes, 112,113 platinum, 114,115 titanium, 116 iron, 117,118 cerium, 119 ruthenium, 120 etc., and/or their hybrid clusters. When light energy is passed through the PS, the ground state oxygen is excited to 1 O 2 and then to the triplet oxygen ( 3 O 2 ) energy state (Fig.…”