Biomedical applications of nano-titania in theranostics and photodynamic therapy

Rehman, Fawad Ur; Zhao, Chunqiu; Jiang, Hui; Wang, X.

doi:10.1039/c5bm00332f

Cited by 116 publications

(66 citation statements)

References 205 publications

(351 reference statements)

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“…The knowledge on the potential application of NPs of TiO 2 and ZnO in therapy and diagnostics of neoplastic maladies is continuously growing. Nonetheless, further studies are necessary to improve the tumor targetability of TiO 2 and ZnO NPs, as well as to increase the therapeutic window of PDT using metal oxide NPs [209, 210]. …”

Section: Reviewmentioning

confidence: 99%

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e.g., in nanomedicine. NMs and NPs are perceived as very promising in cancer therapy since they can perform as drug carriers, as well as photo- or sonosensitizers (compounds that generate the formation of reactive oxygen species as a result of either electromagnetic radiation excitation with an adequate wavelength or ultrasound activation, respectively). Consequently, two new treatment modalities, the photodynamic therapy (PDT) and the sonodynamic therapy (SDT) have been created. The attachment of ligands or antibodies to NMs or to NPs improve their selective distribution into the targeted organ or cell; hence, the therapy effectiveness can be improved. An important advantage of the targeted tumor treatment is lowering the cyto- and genotoxicity of active substance towards healthy cells. Therefore, both PDT and SDT constitute a valuable alternative to chemo- or radiotherapy. The vital role in cancer eradication is attributed to two inorganic sensitizers in their nanosized scale: titanium dioxide and zinc oxide.

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Section: Reviewmentioning

confidence: 99%

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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“…7,8 Understanding water adsorption on TiO 2 is the key not only to efficiently split water molecules (as made use of in hydrogen gas production 9 ) but also to optimize adsorption on, and functionalization of, TiO 2 by larger molecules as mediated via strongly bound surface waters. [10][11][12][13][14][15] On the other hand, concerns have been raised with respect to environmental safety and health when TiO 2 is used in medical implants 16 and as engineered nanoparticles in consumer products. 17 TiO 2 nanoparticles are small enough to penetrate the blood-brain barrier, 18 can aggregate in organisms and the environment, and yield a nanotoxic response by increasing the levels of intracellular reactive oxygen species, leading to apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Diffusion and reaction pathways of water near fully hydrated TiO2 surfaces from ab initio molecular dynamics

Agosta

Brandt

Lyubartsev

2017

The Journal of Chemical Physics

104

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Ab initio molecular dynamics simulations are reported for water-embedded TiO2 surfaces to determine the diffusive and reactive behavior at full hydration. A three-domain model is developed for six surfaces [rutile (110), (100), and (001), and anatase (101), (100), and (001)] which describes waters as “hard” (irreversibly bound to the surface), “soft” (with reduced mobility but orientation freedom near the surface), or “bulk.” The model explains previous experimental data and provides a detailed picture of water diffusion near TiO2 surfaces. Water reactivity is analyzed with a graph-theoretic approach that reveals a number of reaction pathways on TiO2 which occur at full hydration, in addition to direct water splitting. Hydronium (H3O+) is identified to be a key intermediate state, which facilitates water dissociation by proton hopping between intact and dissociated waters near the surfaces. These discoveries significantly improve the understanding of nanoscale water dynamics and reactivity at TiO2 interfaces under ambient conditions.

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“…3 Applications taking advantage of the nanoproperties of the TiO 2 -water interface are numerous in modern technology (e.g., in solar cells, 4 in self-cleaning materials, 5 and during photocatalysis 6,7 ), but concerns have also been raised over the potential health hazards linked to the use of nano-TiO 2 in consumer products. by crossing the blood-brain barrier 11 ) and may be suitable for use in targeted drug delivery 12 and medical implants, 13 since their high surface-to-bulk ratio affords them properties in remarkable contrast to their bulk counterparts. 10 Due to their small size, they may reach previously inaccessible parts of the body (e.g.…”

Section: Introductionmentioning

confidence: 99%

Reactive wetting properties of TiO₂ nanoparticles predicted by ab initio molecular dynamics simulations

2016

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Small-sized wet TiO2 nanoparticles have been investigated by ab initio molecular dynamics simulations. Chemical and physical adsorption of water on the TiO2-water interface was studied as a function of water content, ranging from dry nanoparticles to wet nanoparticles with monolayer coverage of water. The surface reactivity was shown to be a concave function of water content and driven by surface defects. The local coordination number at the defect was identified as the key factor to decide whether water adsorption proceeds through dissociation or physisorption on the surface. A consistent picture of TiO2 nanoparticle wetting at the microscopic level emerges, which corroborates existing experimental data and gives further insight into the molecular mechanisms behind nanoparticle wetting. These calculations will facilitate the engineering of metal oxide nanoparticles with a controlled catalytic water activity.

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Biomedical applications of nano-titania in theranostics and photodynamic therapy

Cited by 116 publications

References 205 publications

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Diffusion and reaction pathways of water near fully hydrated TiO2 surfaces from ab initio molecular dynamics

Reactive wetting properties of TiO₂ nanoparticles predicted by ab initio molecular dynamics simulations

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Biomedical applications of nano-titania in theranostics and photodynamic therapy

Cited by 116 publications

References 205 publications

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Diffusion and reaction pathways of water near fully hydrated TiO2 surfaces from ab initio molecular dynamics

Reactive wetting properties of TiO2 nanoparticles predicted by ab initio molecular dynamics simulations

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Product

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Reactive wetting properties of TiO₂ nanoparticles predicted by ab initio molecular dynamics simulations