New steroidal saponins of Agave americana

Wiłkomirski, Bogusław; Bobeyko, Valentin A.; Кинтя, П. К.

doi:10.1016/0031-9422(75)85245-9

Cited by 20 publications

(12 citation statements)

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“…After removal of the MeOH under reduced pressure, the concentrated extract was partitioned between n-BuOH and H 2 O. The n-BuOH layer was concentrated and applied to a silica gel column, eluting with 6 : 464.3114). The dried sugar residues was diluted in 5 ml pyridine without water and treated with 0.5 ml trimethyl-chlorsilan (TMCS, Fluka) at room temperature for 30 min.…”

Section: Methodsmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14] In a continuation of search for the bioactive saponins produced by agavaceous plants, and to utilize properly the fermented waste residue of A. americana, we have further studied the steroids constituents in the waste residue of fibre separation from A. americana leaves. As the result, three new steroid saponins, agamenosides H-J (1-3), and a new cholestane steroid agavegenin D (4), were isolated, together with six known steroids.…”

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Four New Steroid Constituents from the Waste Residue of Fibre Separation from Agave americana Leaves

2004

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The genus Agave belongs to the Agavaceae family with more than 300 species and occurs natively in arid and tropical regions of western hemisphere, particularly Mexico, and Central America. Among which, several species are of global economic importance, e.g., Agave sisalana, the source of sisal fibre, and other species, such as A. americana, growing world-wide as ornamentals. In China, several species of the genus Agave, such as A. americana and A. sisalana, are widely cultivated in the south part for the fibre industry and as important horticultural plants.Agave americana L., a very large plant with rosettes up to 12 feet broad, is used as an important source for not only textile fibre, but also steroidal sapogenins such as hecogenin and tigogenin in China.1,2) The plant is also used as folk medicine for its antiinflammatory and anti-fungus effects on the treatment of uterus blooding, scabies, etc.3) Since the chemical investigation on the fermented residues of the leaf-juice of A. sisalana led to the identification of some tigogenin glycosides, 4,5) a lot of steroidal sapogenins and saponins were found from the fresh leaves and the fermented leaves of A. americana. [6][7][8][9][10][11][12][13][14] In a continuation of search for the bioactive saponins produced by agavaceous plants, and to utilize properly the fermented waste residue of A. americana, we have further studied the steroids constituents in the waste residue of fibre separation from A. americana leaves. As the result, three new steroid saponins, agamenosides H-J (1-3), and a new cholestane steroid agavegenin D (4), were isolated, together with six known steroids. This paper deals with a full account of the isolation and structural elucidation of these compounds. Results and DiscussionThe MeOH extract of the waste residue of fibre separation from A. american leaves was partitioned by n-BuOH and water. The n-BuOH layer was chromatographed successively over silica gel and RP-8 to afford compounds 1-4 and six known steroids, identified as (25R)-5a-spirostane-3b,6a-diol (chlorogenin),

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Section: Methodsmentioning

confidence: 99%

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Four New Steroid Constituents from the Waste Residue of Fibre Separation from Agave americana Leaves

2004

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“…Additionally, A. sisalana and A. offoyana were found to contain dongnoside E and magueyoside saponins, respectively , . Wilkomirski et al . characterized two steroidal saponins (agavasaponin E and H) from A. americana .…”

Section: Bioactive Compounds In Agave By‐productsmentioning

confidence: 99%

Biological activities ofAgaveby‐products and their possible applications in food and pharmaceuticals

et al. 2017

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Agave leaves are considered a by-product of alcoholic beverage production (tequila, mezcal and bacanora) because they are discarded during the production process, despite accounting for approximately 50% of the total plant weight. These by-products constitute a potential source of Agave extracts rich in bioactive compounds, such as saponins, phenolic compounds and terpenes, and possess different biological effects, as demonstrated by in vitro and in vivo tests (e.g. antimicrobial, antifungal, antioxidant, anti-inflammatory, antihypertensive, immunomodulatory, antiparasitic and anticancer activity). Despite their positive results in biological assays, Agave extracts have not been widely evaluated in food systems and pharmaceutical areas, and these fields represent a potential route to improve the usage of Agave plants as food additives and agents for treating medical diseases. © 2017 Society of Chemical Industry.

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“…Nestes rejeitos encontram-se saponinas esteroidais 14 , também presentes em diversas outras plantas e animais marinhos. As saponinas possuem atividade hemolítica e são tóxicas para peixes.…”

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O aproveitamento do resíduo da indústria do sisal no controle de larvas de mosquitos

Pizarro¹,

Filho

Parente³

et al. 1999

Rev. Soc. Bras. Med. Trop.

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New steroidal saponins of Agave americana

Cited by 20 publications

References 7 publications

Four New Steroid Constituents from the Waste Residue of Fibre Separation from Agave americana Leaves

Four New Steroid Constituents from the Waste Residue of Fibre Separation from Agave americana Leaves

Biological activities ofAgaveby‐products and their possible applications in food and pharmaceuticals

O aproveitamento do resíduo da indústria do sisal no controle de larvas de mosquitos

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