New Steroidal Saponins Isolated from the Rhizomes of Paris mairei

Liu, Yang; Qiu, Pengcheng; Wang, Minchang; Lu, Yang; He, Hao; Tang, Hai‐Feng; Zhang, Bang-Le

doi:10.3390/molecules26216366

Cited by 7 publications

(4 citation statements)

References 27 publications

(31 reference statements)

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“…The cytotoxicity of compounds 1–3 against human cancer cell lines U251, SHG44, LN229 and HepG2 was evaluated by CCK‐8 method which was described in published articles [28] . All cells were cultured in DMEM medium supplemented with 10 % fetal bovine serum, 100 U/mL benzyl penicillin, and 100 U/mL streptomycin at 37 °C in a humidified atmosphere with 5 % CO 2 .…”

Section: Methodsmentioning

confidence: 99%

“…The cytotoxicity of compounds 1-3 against human cancer cell lines U251, SHG44, LN229 and HepG2 was evaluated by CCK-8 method which was described in published articles. [28] All cells were cultured in DMEM medium supplemented with 10 % fetal bovine serum, 100 U/mL benzyl penicillin, and 100 U/mL streptomycin at 37 °C in a humidified atmosphere with 5 % CO 2 . The logarithmic phase cells were seeded on 96-well plates at the concentration of 5 × 10 3 cell/mL and incubated with various concentrations (100, 50, 25, 12.5, 6.25, 3.12, 1.56, 0.78, and 0 μM in medium containing less than 0.1 % DMSO) of test compounds in triple wells for 48 h, and nimustine hydrochloride (ACNU) was used as the positive control.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

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Three New Steriodal Saponins from the Rhizomes of Tupistra chinensis Baker

Yuan

Liu

et al. 2023

Chemistry & Biodiversity

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The phytochemical constituent investigation on the 70 % ethanol extract of the rhizomes of Tupistra chinensis Baker resulted in the isolation of three new steroidal saponins which were named tuchinosides A -C (1-3). Their structures were determined by extensive spectrum analysis and chemical evidence, especially 2D NMR and HR-ESI-MS techniques. In addition, the cytotoxicity of compounds 1-3 against several human cancer cell lines was evaluated.

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Section: Methodsmentioning

confidence: 99%

Section: Cytotoxicity Assaymentioning

confidence: 99%

Three New Steriodal Saponins from the Rhizomes of Tupistra chinensis Baker

Yuan

Liu

et al. 2023

Chemistry & Biodiversity

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“…yunnanensi. Since then, scholars all over the world have isolated about 67 steroidal saponins from 11 species of plants in the genus Paris [82] and have identified 323 compounds respectively [39], including steroidal saponins, phytosterols [83][84][85], polysaccharides [86], triterpenoids [87,88], flavonoids [89,90] and other chemical components [91][92][93]. Steroidal saponins are the primary compounds in P. polyphylla, accounting for about 52% of the total chemical components [39].…”

Section: Bioactives Of P Polyphylla Associated With Acne Treatmentmentioning

confidence: 99%

Saponins of Paris polyphylla for the Improvement of Acne: Anti-Inflammatory, Antibacterial, Antioxidant and Immunomodulatory Effects

Li,

Zhang,

Cheng

et al. 2024

Molecules

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Acne is a chronic inflammatory skin disease with a recurring nature that seriously impacts patients’ quality of life. Currently, antibiotic resistance has made it less effective in treating acne. However, Paris polyphylla (P. polyphylla) is a valuable medicinal plant with a wide range of chemical components. Of these, P. polyphylla saponins modulate the effects in vivo and in vitro through antibacterial, anti-inflammatory, immunomodulatory, and antioxidant effects. Acne is primarily associated with inflammatory reactions, abnormal sebum function, micro-ecological disorders, hair follicle hyperkeratosis, and, in some patients, immune function. Therefore, the role of P. polyphylla saponins and their values in treating acne is worthy of investigation. Overall, this review first describes the distribution and characteristics of P. polyphylla and the pathogenesis of acne. Then, the potential mechanisms of P. polyphylla saponins in treating acne are listed in detail (reduction in the inflammatory response, antibacterial action, modulation of immune response and antioxidant effects, etc.). In addition, a brief description of the chemical composition of P. polyphylla saponins and its available extraction methods are described. We hope this review can serve as a quick and detailed reference for future studies on their potential acne treatment.

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“…latifolia [ 10 ], a variant of the genus Paris , is widely distributed in southwest China. To date, it has only been previously studied in our research group [ 11 , 12 ]. Therefore, this study focused on the cytotoxic steroidal saponins in Paris polyphylla var.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia

Wang³

et al. 2023

IJMS

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A phytochemical investigation of the steroidal saponins from the rhizomes of Paris polyohylla var. latifolia led to the discovery and characterization of three new spirostanol saponins, papolatiosides A–C (1–3), and nine known compounds (4–12). Their structures were established via extensive spectroscopic data analysis and chemical methods. Interestingly, compounds 1 and 2 possessed a fructosyl in their oligosaccharide moiety, which is rare in natural product and was firstly reported in family Melanthiaceae. The cytotoxicity of these saponins against several human cancer cell lines was evaluated by a CCK-8 experiment. As a result, compound 1 exhibited a significant cytotoxic effect on LN229, U251, Capan-2, HeLa, and HepG2 cancer cells with IC50 values of 4.18 ± 0.31, 3.85 ± 0.44, 3.26 ± 0.34, 3.30 ± 0.38 and 4.32 ± 0.51 μM, respectively. In addition, the result of flow cytometry analysis indicated that compound 1 could induce apoptosis of glioma cells LN229. The underlying mechanism was explored by network pharmacology and western bolt experiments, which indicated that compound 1 could induce glioma cells LN229 apoptosis by regulating the EGFR/PI3K/Akt/mTOR pathway.

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New Steroidal Saponins Isolated from the Rhizomes of Paris mairei

Cited by 7 publications

References 27 publications

Three New Steriodal Saponins from the Rhizomes of Tupistra chinensis Baker

Three New Steriodal Saponins from the Rhizomes of Tupistra chinensis Baker

Saponins of Paris polyphylla for the Improvement of Acne: Anti-Inflammatory, Antibacterial, Antioxidant and Immunomodulatory Effects

Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia

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