New Steroidal Saponins from the Leaves of <i>Yucca elephantipes</i>

Zhang, Ying; Yang, Chong‐Ren; Zhang, Yingjun

doi:10.1002/hlca.201200586

Cited by 6 publications

(13 citation statements)

References 11 publications

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“…In our study, we investigated the chemical composition of Y. gigantea in detail using the negative ion mode of LC-ESI-MS/MS, which tentatively revealed the presence of 29 different compounds. Zhang et al [8] reported the isolation of elephanosides G and H, new spirostanol saponins, from the leaves of Yucca elephantipes. Two known furostanol saponins and six known flavonoid glycosides were also separated.…”

Section: Introductionmentioning

confidence: 99%

Elucidation of the Metabolite Profile of Yucca gigantea and Assessment of Its Cytotoxic, Antimicrobial, and Anti-Inflammatory Activities

et al. 2022

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The acute inflammation process is explained by numerous hypotheses, including oxidative stress, enzyme stimulation, and the generation of pro-inflammatory cytokines. The anti-inflammatory activity of Yucca gigantea methanol extract (YGME) against carrageenan-induced acute inflammation and possible underlying mechanisms was investigated. The phytochemical profile, cytotoxic, and antimicrobial activities were also explored. LC-MS/MS was utilized to investigate the chemical composition of YGME, and 29 compounds were tentatively identified. In addition, the isolation of luteolin-7-O-β-d-glucoside, apigenin -7-O-β-d-glucoside, and kaempferol-3-O-α-l-rhamnoside was performed for the first time from the studied plant. Inflammation was induced by subcutaneous injection of 100 μL of 1% carrageenan sodium. Rats were treated orally with YGME 100, 200 mg/kg, celecoxib (50 mg/kg), and saline, respectively, one hour before carrageenan injection. The average volume of paws edema and weight were measured at several time intervals. Levels of NO, GSH, TNF-α, PGE-2, serum IL-1β, IL-6 were measured. In additionally, COX-2 immunostaining and histopathological examination of paw tissue were performed. YGME displayed a potent anti-inflammatory influence by reducing paws edema, PGE-2, TNF-α, NO production, serum IL-6, IL-1β, and COX-2 immunostaining. Furthermore, it replenished the diminished paw GSH contents and improved the histopathological findings. The best cytotoxic effect of YGME was against human melanoma cell line (A365) and osteosarcoma cell line (MG-63). Moreover, the antimicrobial potential of the extract was evaluated against bacterial and fungal isolates. It showed potent activity against Gram-negative, Gram-positive, and fungal Candida albicans isolates. The promoting multiple effects of YGME could be beneficial in the treatment of different ailments based on its anti-inflammatory, antimicrobial, and cytotoxic effects.

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Section: Introductionmentioning

confidence: 99%

Elucidation of the Metabolite Profile of Yucca gigantea and Assessment of Its Cytotoxic, Antimicrobial, and Anti-Inflammatory Activities

et al. 2022

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“…To date, 33 aglycones have been described as part of the saponins found in the Yucca genus [6,7,11,12,14,16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], including spirostanic and furostanic saponins (Figure 2).…”

Section: Aglyconementioning

confidence: 99%

“…The most abundant aglycones in Yucca are the spirostanic ones, but this varies depending on the species. Thus, in the case of Y. elephantipes [19,36] or Y. desmetiana [12,34] furostanic aglycones are mostly isolated. It should be mentioned that C-22 is a chiral centre that always presents an R configuration in the case of the spirostanic derivatives, and it is also R in the case of the furostanic derivatives where the configuration has been described.…”

Section: Aglyconementioning

confidence: 99%

“…In addition to glucose, 22 different sugar chains have been described in Yucca. These are linked to aglycones on the C-3 position [6,7,11,12,14,16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. The chains described in this genus possess up to seven monosaccharides.…”

Section: Sugar Chainsmentioning

confidence: 99%

“…106 spirostanic and furostanic saponins (Table 1) have been reported in the species of the Yucca genus that have been studied, namely Y. gloriosa, Y. glauca, Y. schidigera, Y. aloifolia, Y. desmetiana, Y. elephantipes Y. macrocarpa, and Y. smalliana [6,7,11,12,14,16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. Only a few of these have been studied in depth, which lead us to conclude that the saponins from the Yucca genus remain a rather underexplored field.…”

Section: Saponins In the Yucca Genusmentioning

confidence: 99%

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Structure, Bioactivity and Analytical Methods for the Determination of Yucca Saponins

et al. 2021

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Yucca is one of the main sources of steroidal saponins, hence different extracts are commercialized for use as surfactant additives by beverage, animal feed, cosmetics or agricultural products. For a deeper understanding of the potential of the saponins that can be found in this genus, an exhaustive review of the structural characteristics, bioactivities and analytical methods that can be used with these compounds has been carried out, since there are no recent reviews on the matter. Thus, a total of 108 saponins from eight species of the genus Yucca have been described. Out of these, the bioactivity of 68 saponins derived from the isolation of Yucca or other genera has been evaluated. Regarding the evaluation and quality control of the saponins from this genus LC-MS technique is the most often used. Nevertheless, the development of methods for their routine analysis in commercial preparations are needed. Moreover, most of the studies found in the literature have been carried out on Y. schidigera extract, since is the most often used for commercial purposes. Only eight of the 50 species that belong to this genus have been studied, which clearly indicates that the identification of saponins present in Yucca genus is still an unresolved question.

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Steroidal Saponins from Solanum lyratum Thunb.

Lai,

Zhao,

Gao

et al. 2023

Chemistry & Biodiversity

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Four undescribed steroidal compounds along with twenty known compounds were isolated from n‐butanol extracted fraction of the whole plants of Solanum lyratum Thunb (SLNF). Their structures were assigned based on analyses of the extensive spectroscopic data (including MS, 1D/2D NMR, and ECD) or comparisons of the NMR data with those reported. Among the knowns, three compounds were isolated from Solanum plants for the first time, while one compound was isolated from S. lyratum for the first time. In addition, the cytotoxicities of these isolates against human colon SW480 and hepatoma Hep3B cells were evaluated by a MTT assay. And, nine of them and SLNF exhibited significant activities against both SW480 and Hep3B cells, while twelve of them significantly inhibited the activities of SW480 cells. This study allows for the exploitation of chemical markers with potential significance in discrimination of Solanum plants, and uncovers the diverse steroidal constituents from S. lyratum dedicated for its future application in cancer treatment.

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New Steroidal Saponins from the Leaves of Yucca elephantipes

Cited by 6 publications

References 11 publications

Elucidation of the Metabolite Profile of Yucca gigantea and Assessment of Its Cytotoxic, Antimicrobial, and Anti-Inflammatory Activities

Elucidation of the Metabolite Profile of Yucca gigantea and Assessment of Its Cytotoxic, Antimicrobial, and Anti-Inflammatory Activities

Structure, Bioactivity and Analytical Methods for the Determination of Yucca Saponins

Steroidal Saponins from Solanum lyratum Thunb.

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