A practical route is described for the preparation of myo‐inositol phosphates. Optically pure compounds can be prepared, in both forms, from p‐benzoquinone by enzymatic resolution of a diacetoxyconduritol key intermediate. Monosubstituted inositol derivatives can be obtained by breaking the C2 symmetry of conduritol B derivatives. A wide variety of myo‐inositol phosphates can be synthesized by combining the previously reported symmetrical approach with this new nonsymmetrical approach. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)