New Solvent-Free Organic Synthesis Using Focused Microwaves

Abstract

In this review, we report the advantages of dry reaction techniques coupled with focused microwave activation and their applications to organic synthesis using acidic and basic supports, and enzymatic or phase-transfer catalysis.

Microwave Assisted Improved Method for the Synthesis, Characterization of 1-(2-Hydroxy Phenyl)-Methanone-3,5-Disubstituted Pyrazolines

“…The pharmaceutical importance of these compounds lies in the fact that they can be effectively utilized as analgesic 1 , antioxidant 2 , antidepressant 3 , anticancer 4 and antidiabetic agents 5 , immunosuppressive effect 6 and antitumor activity 7 of some pyrazolines derivatives are also known. Microwave [8][9][10][11][12][13] has been applied in science research as an assistant technique or a method to chemical synthesis. It may be considered as a green chemistry technique which focuses on more efficient and faster reaction than conventional method.…”

Biological Screening of Novel Derivatives of Valproic Acid for Anticancer and Antiangiogenic Properties

“…Hydrazones have been demonstrated to posses, antimicrobial, anticonvulsant, analgesic, antiinflammatory, antiplatelet, antitubercular and antitumor activities (Loupy et al, 1998;Kucukguzel, 1999;Kucukguzel et al, 2002;Rollas et al, 2002).…”

A new one pot and solvent-free synthesis of nickel porphyrin complex

“…Firstly, a large amount of solvent is used and secondly, the preparation requires 8 hours of heating. In the present work, we report a solvent free and microwave assisted synthesis of porphyrin using benzaldehyde and pyrrole which is prepared by a slightly modified method of Loupy (25) followed by the preparation of the nickel porphyrin by a solvent free, microwave assisted reaction using 1,8-diazabicyclo [5.4.0] undec-7-ene (DBU) as a base. We also report a novel one pot method of synthesis for nickel porphyrin starting from pyrrole, benzaldehyde, nickel (II) chloride, and DBU as a base.…”