New Sesquiterpenoids from<i>Chrysanthemum indicum</i>var.<i>tuneful</i>

Mladenova, Kirilka; Tsankova, Elena; Hung, Dinh van

doi:10.1055/s-2006-962548

Cited by 25 publications

(9 citation statements)

References 4 publications

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“…Thorough phytochemical and biological investigations of both plants led to the isolation and identification of many bioactive secondary metabolites represented mainly by flavonoids, steroids and terpenoids [ 12 , 13 , 14 , 15 , 16 , 17 ]. These plants exhibit strong antibacterial, antiviral, antioxidant, antihypertension, anti-inflammatory and immunomodulatory activities [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Chrysanthemum indicum and Chrysanthemum morifolium: Chemical Composition of Their Essential Oils and Their Potential Use as Natural Preservatives with Antimicrobial and Antioxidant Activities

Youssef

Eid

Alshammari

et al. 2020

Foods

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The composition of essential oils of Chrysanthemum indicum and C. morifolium were comparatively studied using both Gas Chromatography/Flame ionization Detector (GC/FID) and Gas Chromatography/Mass spectrometry (GC/MS) analyses. The antiviral activity was determined using a plaque reduction assay against three common viruses namely, herpes simplex type-1 (HSV-1), hepatitis A (HAV) and vesicular stomatitis virus (VSV). The antimicrobial activity was assessed using agar diffusion and microdilution methods and the minimum inhibitory concentration (MIC) values were determined. In addition, the anti-mycobacterial evaluation was carried out using the Alamar blue assay and the effect against Helicobacter pylori was investigated. The anti-trypanosomal activity was evaluated using the resazurin method. GC investigations revealed that camphor is the major constituent of both oils accounting for 36.69 and 14.56% in the essential oils from C. indicum and C. morifolium, respectively. C. indicum was biologically more active in all experiments; it exhibited a notable antitrypanosomal activity with an IC50 value equals 45.89 μg/mL and a notable antimicrobial activity versus Streptococcus agalactiae with a MIC value of 62.5 μg/mL. It also inhibited the replication of VSV with an IC50 value of 3.14 μg/mL. Both oils revealed antioxidant potential with IC50 values of 2.21 and 2.59 mg/mL for C. indicum and C. morifolium, respectively. This study provides evidence beyond the traditional use of both Chrysanthemum indicum and C. morifolium as anti-infective agents. Thus they could be used as spices in food and can be incorporated in different food products and pharmaceutical preparations as natural preservatives possessing antioxidant potential.

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Section: Introductionmentioning

confidence: 99%

Chrysanthemum indicum and Chrysanthemum morifolium: Chemical Composition of Their Essential Oils and Their Potential Use as Natural Preservatives with Antimicrobial and Antioxidant Activities

Youssef

Eid

Alshammari

et al. 2020

Foods

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“…The flower portion of chrysanthemum (Chrysanthemum morifolium Ramat) has also been eliciting interest as a dietary and medicinal substance. The flowers contain essential oils, flavonoids, and their glycosides (Mladenova et al, 1988). Because chrysanthemum flower has various biological activities such as antioxidant, antimutagenic, and anti-HIV effects (Kim and Lee, 2005;Lee et al, 2003;Miyazaki and Hisama, 2003), CFO (Kaneka Chrysflavone TM ) was developed as an oily fraction containing polyphenols derived from chrysanthemum flowers (Honda et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Preparation of a Highly Water-dispersible Powder Containing Hydrophobic Polyphenols Derived from Chrysanthemum Flower with Xanthine Oxidase-inhibitory Activity

Kadota

Hashimoto

Yamaguchi

et al. 2018

FSTR

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We aimed to develop a highly water-dispersible dry powder of hydrophobic polyphenols derived from chrysanthemum flower. A dry powder resulting from the mixture of an ethanolic extract of chrysanthemum flower (CF) with transglycosylated rutin (rutin-G) and sucrose fatty acid esters (SEs) was successfully formulated. This powder dispersed easily in water, and the mean particle size in water remained at ~150 nm without apparent changes even after one-week storage. Furthermore, the particle size of the dispersed powder prepared by heat-and-acid treatment shifted below 100 nm after one-week storage. The xanthine oxidase-inhibitory activity of the resulting CF-rutin-G-SEs powder was almost equivalent to that of chrysanthemum flower oil according to in vitro analysis. This technique for preparing a highly water-dispersible dry powder from natural products containing hydrophobic polyphenols should be applicable to the development of functional food products.

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“…Its flowers contain essential oil, sesquiterpenes, flavonoids, and their glycosides. 1,2) It has been reported that these flowers have various biological activities, such as anti-oxidation, 3) anti-inflammation, 4,5) oncogenic suppression, 6) anti-mutagenicity, 7) and anti-HIV. 8) We developed chrysanthemum flower oil (CFO; Kaneka Chrysflavone TM ) as an oily fraction containing polyphenols derived from chrysanthemum flowers.…”

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confidence: 99%

Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis

Honda

Kawamoto

Tanaka

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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New Sesquiterpenoids fromChrysanthemum indicumvar.tuneful

Abstract: Extraction, isolation, and identification of a!kaloidsThe dried and ground stems (400 g) were extracted with ethanol, the ethanolic extract (18 g) was stirred with dilute hydrochloric acid, and filtered. The filtrate was alkalinized with

Cited by 25 publications

References 4 publications

Chrysanthemum indicum and Chrysanthemum morifolium: Chemical Composition of Their Essential Oils and Their Potential Use as Natural Preservatives with Antimicrobial and Antioxidant Activities

Chrysanthemum indicum and Chrysanthemum morifolium: Chemical Composition of Their Essential Oils and Their Potential Use as Natural Preservatives with Antimicrobial and Antioxidant Activities

Preparation of a Highly Water-dispersible Powder Containing Hydrophobic Polyphenols Derived from Chrysanthemum Flower with Xanthine Oxidase-inhibitory Activity

Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis

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