New ruthenium(II) complexes with N-alkylphenothiazines: Synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxicity

Krstić, Marija; Sovilj, Sofija P.; Grgurić-Šipka, Sanja; Evans, Ivana Radosavljević; Borozan, Sunčica; Santibáñez, Juan F.; Kocić, Jelena

doi:10.1016/j.ejmech.2010.05.013

Cited by 16 publications

(11 citation statements)

References 51 publications

(36 reference statements)

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“…Ruthenium(II) complexes showed effects on the activity of antioxidative blood enzymes (SOD and CAT) in rats treated i.p. with complexes at three different doses: 0.4, 4.5 and 90.4 μmol kg -1 bw [35,36].…”

Section: Resultsmentioning

confidence: 99%

“…In the reaction the starting complex RuCl 2 ( 6 -p-cymene) 2 with TF.2HCl in 2-propanol as solvent, complex 2 (TF.2H)RuCl 3 ( 6 -p-cymene) Cl·0.5C 3 H 7 OH·0.5H 2 O was synthesized [36]. Both complexes were characterized by elemental analysis, spectroscopic methods and x-ray diffraction as previously described [35,36].…”

Section: Chemicalsmentioning

confidence: 99%

“…The complex (TF.2H)Ru(DMSO) 3 Cl 3 Cl·0.5C 2 H 5 OH (1) was prepared by the reaction of complex RuCl 2 (DMSO) 4  and trifl uoperazine dihydrochloride (TF.2HCl) in absolute ethanol [35]. In the reaction the starting complex RuCl 2 ( 6 -p-cymene) 2 with TF.2HCl in 2-propanol as solvent, complex 2 (TF.2H)RuCl 3 ( 6 -p-cymene) Cl·0.5C 3 H 7 OH·0.5H 2 O was synthesized [36].…”

Section: Chemicalsmentioning

confidence: 99%

“…In continuation of our previous research [35,36], the aim of the present study was to investigate the effect of two ruthenium complexes with trifl uoperazine, previously prepared and characterized in our laboratory (Scheme 1), on acethylcholinesterase enzyme activity in rats blood as well as their ability to infl uence LDH levels in vivo under physiological conditions.…”

Section: Introductionmentioning

confidence: 99%

“…New Ru(II)-DMSO and Ru(II)-p-cymene complexes with N-alkylphenothiazines were previously synthesized and characterized by elemental analysis and spectroscopic methods (FT-IR, UV-Vis, 1 H and 13 C NMR) [35,36]. These complexes showed effects on antioxidative enzymes, as well as malondyaldehyde and nitrite levels in rats blood.…”

Section: Introductionmentioning

confidence: 99%

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In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

et al. 2016

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The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifl uoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH 1 and LDH 2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH 2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro-and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.

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Section: Resultsmentioning

confidence: 99%

Section: Chemicalsmentioning

confidence: 99%

Section: Chemicalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

et al. 2016

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Novel Cr (III), Fe (III) and Ru (III) Vanillin Based Metallo‐Pharmaceuticals for Cancer and Inflammation Treatment: Experimental and Theoretical Studies

Abdel‐Rahman

El‐Khatib

Abdel‐Fatah

et al. 2019

Applied Organom Chemis

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In this study, three novel complexes comprising trivalent Cr (III), Fe (III) and Ru (III) with imine ligand derived from 2-amino-3-hydroxypyridine and ovanillin (H 2 L) have been synthesized and characterized via wide range of spectroscopic and analytical tools such as 1 H NMR and 13 C NMR, infrared (IR) and UV-Vis spectrophotometry, conductivity and magnetic measurements. The obtained results along with DFT data confirmed a 1:1 (metal: ligand) stoichiometry with non-planner geometries for the three complexes. The binding action and the docking study of the prepared metal-complexes to calf thymus DNA was also studied by absorption spectra and viscosity technique, which revealed that the three complexes interact strongly with DNA through intercalative binding mode. Significantly, these metal-imine complexes showed strong and efficient anti-inflammatory and antimicrobial activities against various gram-positive (Microccus luteus), gram-negative (Escherichia coli and Serratia marcescence) bacteria, and three strains of fungus. Moreover, all complexes exhibited more potent cytotoxicity effect on the outgrowth of different types of carcinoma cells, including human colon (HCT-116 cell line), breast (MCF-7 cell line), and hepatic cellular (HepG-2), than the clinically-proven Vinblastine standard.

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Ruthenium–Porphyrin Complexes Induce Apoptosis by Inhibiting the Generation of Intracellular Reactive Oxygen Species in the Human Hepatoma Cell Line (HepG₂)

et al. 2011

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New ruthenium(II) complexes with N-alkylphenothiazines: Synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxicity

Cited by 16 publications

References 51 publications

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

Novel Cr (III), Fe (III) and Ru (III) Vanillin Based Metallo‐Pharmaceuticals for Cancer and Inflammation Treatment: Experimental and Theoretical Studies

Ruthenium–Porphyrin Complexes Induce Apoptosis by Inhibiting the Generation of Intracellular Reactive Oxygen Species in the Human Hepatoma Cell Line (HepG₂)

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New ruthenium(II) complexes with N-alkylphenothiazines: Synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxicity

Cited by 16 publications

References 51 publications

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

Novel Cr (III), Fe (III) and Ru (III) Vanillin Based Metallo‐Pharmaceuticals for Cancer and Inflammation Treatment: Experimental and Theoretical Studies

Ruthenium–Porphyrin Complexes Induce Apoptosis by Inhibiting the Generation of Intracellular Reactive Oxygen Species in the Human Hepatoma Cell Line (HepG2)

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Ruthenium–Porphyrin Complexes Induce Apoptosis by Inhibiting the Generation of Intracellular Reactive Oxygen Species in the Human Hepatoma Cell Line (HepG₂)