New Rheological Model for Analyzing the Aggregatability and Deformability of Erythrocytes in a Number of Hematological Pathologies

Analysis of rheograms of the blood of patients with myocardial ischemia and type-2 diabetes mellitus with the use of a new model in the process of pharmaceutical therapy

“…The parameter γ 1 increases with increase in the aggregation forces, and the parameter γ 2 increases when the membrane elasticity increases [13]. The parameter a 2 is also independent of the hematocrit and the rate of shear, and the parameter a 1 is a sigma function of the hematocrit with a half-inflection point in the region of Hct .…”

“…Since the available data on the rheology of the blood and plasma of patients with the above-indicated diseases are fairly discrepant, the aim of the present work was to investigate the curves of the blood flow in patients with MI, patents with MI + DM2, but donors with the use of a new rheological model proposed by the authors in [12,13].…”

“…The curves of large blood flows of patients with MI, patients with MI +DM2, and donors were estimated using an adopted variant of the model proposed by the authors in [12,13]: ln (η ⁄ η pl ) = A⋅Hct B , A = 2.5exp (a 1 exp (-γ ⁄ γ 1 ) + a 2 exp (-γ ⁄ γ 2 )) , B = 1 + ln (2.5 ⁄ A) .…”

“…The rheological model (formulas (1)) proposed by us in [12,13] allows one to adequately diagnose the rheological disturbances of the blood and interpret the possible physical reasons for these disturbances at the cell level. It is shown that a characteristic of normal blood is a distinct correlation dependence (2) for the parameters γ 1 and γ 2 , which is absent in patients with MI and MI + DM2.…”