Analysis of rheograms of the blood of patients with myocardial ischemia and type-2 diabetes mellitus with the use of a new model in the process of pharmaceutical therapy

Abstract

Curves of the blood flow in patents with myocardial ischemia (MI), patients with MI and type-2 diabetes mellitus (MI + DM2), and donors have been analyzed using a rheological model proposed by the authors. The influence of the standard antianginal and antiaggregative therapy on the parameters of this model has been investigated. It has been established that the four parameters of the model are reliably changed for both groups of patients as compared to those for the healthy donors, and that, for the donors, there exists a temperature-dependent correlation between the other two parameters of the model that is absent for the patients. A criterion is proposed for estimating a normal blood-flow curve at 25 o C. It is shown that the antianginal and antiaggregative therapies do not influence the parameters of the model for the patients studied.Introduction. In patients with cardiologic pathologies [1, 2] and type-2 diabetes mellitus (DM2) [3], the viscosity of the blood and plasma is increased. In the case of DM2, the deformation ability of the erythrocytes is adversely affected [4] and their aggregation is activated, which should increase the viscosity of the blood at high [5] and low [6] rates of shear. The extracorporeal precipitation of the fibrinogen, low-density lipoproteins, total cholesterin, triglycerides, and α-lipoproteins normalizes the rheology of the blood [7]. A negative correlation between the blood viscosity and the cholesterin of the high-density lipoproteins and a positive correlation between the blood viscosity and the fibrinogen were detected. The blood viscosity correlates positively with the concentration of total protein, triglycerides, and low-density cholesterin [8]. The ratio between the low-density and high-density lipoproteins in the plasma is an important parameter determining cardiovascular risk [9].However, the corresponding literature data are very contradictory. For example, it is reported in [10] that an increase in the concentration of triglycerides in the plasma enhances the erythrocyte aggregation but does not influence the viscosity of the blood, but the authors of [11] note that this increase leads to an increase in the viscosity of the blood and the plasma.Since the available data on the rheology of the blood and plasma of patients with the above-indicated diseases are fairly discrepant, the aim of the present work was to investigate the curves of the blood flow in patients with MI, patents with MI + DM2, but donors with the use of a new rheological model proposed by the authors in [12,13].Materials and Methods. We investigated the blood of a group of donors (20 persons), a group of patients with MI (33 persons), and a group of patients with MI + DM2 (42 persons). The blood was taken by the standard method from the vein into the anticoagulant ethylenediamine tetraacetate. Cytometric indices (packed cell volume, erythrocyte concentration) were measured using a Hemacomb-10 automated hemoanalyzer. Each patient was subjected to rheological and biochemical measurements (total protein...