New Research Routes to Fight Myopia

González-Meijóme, José Manuel

doi:10.1016/j.ebiom.2017.01.022

Cited by 3 publications

(3 citation statements)

References 9 publications

(9 reference statements)

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“…Different optical strategies have been developed and implemented over the past 10 to 15 years in an attempt to address this evolving global health concern 1 . Beyond the pattern of image formation, it is increasingly evident that the spectral composition and intensity of light are important to consider when attempting to interfere with myopia progression 2 , 3 . The contribution of intrinsically photosensitive retinal ganglion cells (ipRGCs) to different physiological functions has been elucidated in recent years and it is now possible to link ipRGCs to the modulation of the retinal activity 4 .…”

Section: Introductionmentioning

confidence: 99%

Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes

Amorim‐de‐Sousa

Schilling

Fernandes

et al. 2021

Sci Rep

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Upregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p < 0.001) and 10 min (p < 0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for ‘Time after stimulation’ (p < 0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system.

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Section: Introductionmentioning

confidence: 99%

Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes

Amorim‐de‐Sousa

Schilling

Fernandes

et al. 2021

Sci Rep

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“…The vast majority of children's myopia is due to the long-term contraction of ciliary muscle under the condition of close visual activities without relaxing, which weakens the stretching ability of ciliary mustle and results in its loss of relaxation ability ( 8 ). In this case, improving the ciliary-muscle adjusting function is the key to prevent and slow down the formation of myopia ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of physical activity combined with extra ciliary-muscle training on visual acuity of children aged 10–11

Rong-bin

Wang

et al. 2022

Front. Public Health

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This study is intended for exploring the effects of the physical activity combined with extra ciliary-muscle training with different frequencies on children's kinetic visual acuity and uncorrected distance visual acuity, and eventually figuring out the optimal frequency of ciliary-muscle training for each physical education class. To do the present research, A total of 160 students aged 10–11 from a school in Suzhou (a major city located in southeastern Jiangsu Province, East China) were randomly selected and divided into control group (n = 33), 15-frequency group (n = 44), 30-frequency group (n = 40) and 60-frequency group (n = 43), and the latter three experimental groups participated in a specially designed physical activity plan based on the training principles of ciliary muscle, while the control group participated in normal physical activity as usual. The experimental intervention period was 16 weeks, and all students' kinetic visual acuity and uncorrected distance visual acuity were measured before and after the experiment. The result showed that the kinetic visual acuity of the students in the 30 and 60-frequency groups got improved significantly after the experiment (p < 0.05), with the highest improvement occurring in the 30-frequency group, while there was no significant change in the 15-frequency group and the control group; The uncorrected distance visual acuity of the students in the 30 and 60-frequency groups was significantly improved after the experiment (p < 0.05), and the improvement range in these two groups was similar. In contrast, there was no significant change in the 15-frequency group, while the control group showed a significant decrease (p < 0.05). Physical activity combined with extra ciliary-muscle training has a positive effect on improving children's vision; at the same time, ciliary-muscle training with different frequencies bring out different outcomes on children's vision improvement, among which ciliary-muscle training with frequency of 30 in each physical education class is the best choice to enhance children's kinetic visual acuity and uncorrected distance visual acuity.

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“…Thank you very much for your positive comments ( González-Méijome, 2017 ) on our paper ( Torii et al, 2017 ). As you have noted the cause and effect between violet light exposure and axial elongation of the eye has yet to be confirmed, and of course, there is the possibility that other mechanisms may be involved as well.…”

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confidence: 98%